Results 1 to 10 of about 30,659 (115)
The Tryptophan–Kynurenine Pathway in Immunomodulation and Cancer Metastasis
Cancer Medicine, 2023 Introduction The activation of the kynurenine pathway in cancer progression and metastasis through immunomodulatory pathways has drawn attention to the potential for kynurenine pathway inhibition.
June C Serem +2 more
exaly +2 more sources
Identification of Gut Microbiome Signatures Associated with the Kynurenine Pathway in Tryptophan Metabolism in Patients Undergoing Hemodialysis [PDF]
MicroorganismsPatients with chronic kidney disease (CKD) and hemodialysis (HD) often experience gut microbiota dysbiosis, which may influence tryptophan metabolism through the kynurenine pathway.
Jih-Kai Huang +9 more
doaj +2 more sources
The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
Molecules, 2022 Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan.
Robert S. Phillips, J Phillip Bowen
exaly +3 more sources
Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition
Frontiers in Molecular Biosciences, 2019 The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips +2 more
exaly +3 more sources
Synchronous spectrofluorimetric determination of tryptophan and kynurenine in human plasma using hydroxypropyl-β-cyclodextrin complexation for investigating their role in major depressive disorder [PDF]
Scientific ReportsMajor depressive disorder (MDD) is recently associated with immunological activation and deregulation of the kynurenine pathway, which redirects tryptophan metabolism away from serotonin production and towards neuroactive metabolites.
Adnan Alharbi +4 more
doaj +2 more sources
The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]
Medicinski Podmladak, 2023 The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš +2 more
doaj +1 more source
Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo
EBioMedicine, 2021 Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce less ...
Peter J. Siska +22 more
doaj +1 more source
Diagnostics, 2022 Kynurenine is a tryptophan metabolite linked to several inflammatory processes including transplant failure, a significant challenge in transplant medicine. The detection of small molecules such as kynurenine, however, is often complex and time consuming.
Max Borgolte +4 more
doaj +1 more source
Scientific Reports, 2021 Inflammation increases the risk of cardiometabolic disease. Delineating specific inflammatory pathways and biomarkers of their activity could identify the mechanistic underpinnings of the increased risk. Plasma levels of kynurenine, a metabolite involved
Minoo Bagheri +16 more
doaj +1 more source
Journal of Neuroinflammation, 2021 Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS
Vincent Millischer +9 more
doaj +1 more source