Results 1 to 10 of about 47,432 (263)
The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors [PDF]
Molecules, 2022 Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan.
Tamera D. Hughes +4 more
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L-kynurenine or nicotinamide supplementations mitigate uterine decidualization impairments during early pregnancy of uninephrectomized mice [PDF]
Frontiers in PhysiologyImpaired renal reserve induced by unilateral nephrectomy (UNx) leads to the full-spectrum of phenotypes of preeclampsia (PE) in mice. L-kynurenine (a product of L-tryptophan metabolism) supplementation throughout the entire pregnancy rescues the PE-like ...
Yuye Wang +5 more
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Kynurenine mediates the chemotherapy-induced intestinal toxicity through modulation of gut microbiota [PDF]
Nature CommunicationsChemotherapy-induced intestinal toxicity is a major dose-limiting complication, but the underlying mechanisms linking systemic metabolism to localized gut damage are poorly understood.
Hongyu Xie +13 more
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Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo
EBioMedicine, 2021 Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce less ...
Peter J. Siska +22 more
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Scientific Reports, 2021 Inflammation increases the risk of cardiometabolic disease. Delineating specific inflammatory pathways and biomarkers of their activity could identify the mechanistic underpinnings of the increased risk. Plasma levels of kynurenine, a metabolite involved
Minoo Bagheri +16 more
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Diagnostics, 2022 Kynurenine is a tryptophan metabolite linked to several inflammatory processes including transplant failure, a significant challenge in transplant medicine. The detection of small molecules such as kynurenine, however, is often complex and time consuming.
Max Borgolte +4 more
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The tryptophan–kynurenine pathway in immunomodulation and cancer metastasis
Cancer Medicine, 2023 Introduction The activation of the kynurenine pathway in cancer progression and metastasis through immunomodulatory pathways has drawn attention to the potential for kynurenine pathway inhibition.
Charlise Basson +3 more
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The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]
Medicinski Podmladak, 2023 The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš +2 more
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Frontiers in Immunology, 2021 ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses.
Katrien Skorobogatov +13 more
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Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease. [PDF]
PLoS ONE, 2015 The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the pathogenesis of a wide variety of inflammatory, neurodegenerative and malignant disorders ...
Simon P Jones +8 more
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