Results 1 to 10 of about 2,991,386 (293)

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors [PDF]

Molecules, 2022
Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan.
Tamera D. Hughes, Osman F. Güner, Emma Carine Iradukunda, Robert S. Phillips, J. Phillip Bowen   +4 more
doaj   +6 more sources

The tryptophan–kynurenine pathway in immunomodulation and cancer metastasis

Cancer Medicine, 2023
Introduction The activation of the kynurenine pathway in cancer progression and metastasis through immunomodulatory pathways has drawn attention to the potential for kynurenine pathway inhibition.
Charlise Basson, June Cheptoo Serem, Yvette Nkondo Hlophe, Priyesh Bipath   +3 more
doaj   +4 more sources

Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease

Frontiers in Immunology, 2022
Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc.
Renáta Gáspár, Renáta Gáspár, Dóra Halmi, Dóra Halmi, Virág Demján, Virág Demján, Róbert Berkecz, Márton Pipicz, Márton Pipicz, Tamás Csont, Tamás Csont   +10 more
doaj   +2 more sources

Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions

Molecular Pain
Chronic pain is a debilitating symptom with a significant negative impact on the quality of life and socioeconomic status, particularly among adults and the elderly.
Ebrahim Hazrati, Seyed Parsa Eftekhar, Reza Mosaed, Saeed Shiralizadeh Dini, Mehrshad Namazi   +4 more
doaj   +2 more sources

Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain

Pharmaceuticals, 2023
Chronic pain is a pressing medical and socioeconomic issue worldwide. It is debilitating for individual patients and places a major burden on society in the forms of direct medical costs and lost work productivity.
Andrew Auyeung, Hank C. Wang, Kannan Aravagiri, Nebojsa Nick Knezevic   +3 more
doaj   +2 more sources

Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway

Cell Communication and Signaling, 2023
Background Metabolic reprogramming is a critical event for cell fate and function, making it an attractive target for clinical therapy. The function of metabolic reprogramming in Helicobacter pylori (H.
Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong, Wanfu Xu   +10 more
doaj   +2 more sources

The Kynurenine Pathway and Indole Pathway in Tryptophan Metabolism Influence Tumor Progression

Cancer Medicine
Tryptophan (Trp), an essential amino acid, is solely acquired through dietary intake. It is vital for protein biosynthesis and acts as a precursor for numerous key bioactive compounds.
Zhanhui Lu, Chengcheng Zhang, Jia Zhang, Wan Su, Guoying Wang, Zhongqi Wang   +5 more
doaj   +2 more sources

Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders

Frontiers in Immunology, 2021
ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses.
Katrien Skorobogatov, Katrien Skorobogatov, Livia De Picker, Livia De Picker, Robert Verkerk, Violette Coppens, Violette Coppens, Marion Leboyer, Marion Leboyer, Marion Leboyer, Marion Leboyer, Norbert Müller, Manuel Morrens, Manuel Morrens   +13 more
doaj   +2 more sources

A history of suicide attempts among individuals with schizophrenia is associated with tryptophan degradation via the salivary kynurenine pathway [PDF]

BMC Psychiatry
Background Tryptophan, an essential precursor metabolite within the kynurenine pathway, has been implicated in the neurobiological mechanisms underlying both schizophrenia and associated suicidality. Despite this link, the lack of validated biomarkers to
Yi Yin, Ting Xie, Jinghui Tong, Junchao Huang, Baopeng Tian, Mengzhuang Gou, Song Chen, Shuping Tan, Zhiren Wang, Yongsheng Tong, Yanfang Zhou, Leilei Wang, Yunlong Tan   +12 more
doaj   +2 more sources

Serum Kynurenine Pathway Metabolites as Candidate Diagnostic Biomarkers for Pituitary Adenoma: A Case–Control Study [PDF]

Medicina
Background and Objectives: Pituitary adenomas are common intracranial tumors lacking specific non-invasive biomarkers. This study aimed to determine whether key metabolites and enzymes of the kynurenine pathway—including indoleamine 2,3-dioxygenase (IDO),
Nur Düzen Oflas, Halil İbrahim Akbay, Murat Alay, Mehmet Erdem   +3 more
doaj   +2 more sources