Results 1 to 10 of about 13,713 (220)

Cerebrospinal fluid neopterin analysis in neuropediatric patients: establishment of a new cut off-value for the identification of inflammatory-immune mediated processes. [PDF]

PLoS ONE, 2013
ObjectiveA high level of cerebrospinal fluid (CSF) neopterin is a marker of central nervous system inflammatory-immune mediated processes. We aimed to assess data from 606 neuropediatric patients, describing the clinical and biochemical features of those
Marta Molero-Luis, Sergio Fernández-Ureña, Iolanda Jordán, Mercedes Serrano, Aida Ormazábal, Àngels Garcia-Cazorla, Rafael Artuch, Neopterin Working Group   +7 more
doaj   +4 more sources

Age-Dependent Variation in Blood Biopterin Peaks Following Oral Tetrahydrobiopterin Administration in Phenylketonuria. [PDF]

J Inherit Metab Dis
ABSTRACT The correct diagnosis of tetrahydrobiopterin (BH4, sapropterin dihydrochloride)‐responsive phenylketonuria (PKU) and treatment with BH4 are important for prognosis and quality of life. We examined whether age affects biopterin bioavailability following oral BH4 administration in PKU and whether this influences BH4 responsiveness.
Kitayama K, Sakaguchi T, Nakano N, Kabata D, Shintaku H, Hamazaki T.   +5 more
europepmc   +2 more sources

Urinary Neopterin in Malignant Lymphoma

The International Journal of Biological Markers, 1991
Urinary neopterin levels were studied in 96 patients with malignant lymphomas. Twenty-eight had Hodgkin's disease and 68 non-Hodgkin's lymphoma. Neopterin excretion was significantly related to the clinical stage of the disease.
L. Piccinini, S. Zironi, M. Federico, L. A. Pini, G. Luppi   +4 more
doaj   +4 more sources

Gut metabolites identified in cerebrospinal fluid of genetic interferonopathy support gut-brain endothelial dysfunction. [PDF]

Clin Transl Immunology
Abstract Objective Aicardi–Goutières syndrome (AGS) is a rare genetic interferonopathy because of aberrant DNA or RNA metabolism with secondary host anti‐viral (interferon) activation. This metabolomics study aimed to improve the biological understanding of AGS and explore potential biomarkers.
Dale RC, Elbourne M, Hofer MJ, Patel S, Mohammad S, Han VX, Yu J, Fu S, D'Silva A, Farrar MA, Bandodkar S, Yan JJ.   +11 more
europepmc   +2 more sources

A Novel Multimodal LC-MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF. [PDF]

J Inherit Metab Dis
ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Christ S, Rossmann J, Richter S, Garbade S, Klinke G, Blau N, Hoffmann GF, Okun JG, Opladen T.   +8 more
europepmc   +2 more sources

Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations. [PDF]

Am J Biol Anthropol
ABSTRACT Objectives Whereas chronic inflammation is a hallmark of aging in many human populations, inflammaging is reduced in groups characterized by frequent physical activity and diets low in processed foods. Since most biomarkers of inflammation require blood sampling, comparative data from our closest primate relatives have been derived from ...
Cole MF, Emery Thompson M, Thompson González N, Paskus E, Rukundo J, Atencia R, Rosati AG.   +6 more
europepmc   +2 more sources

Return to an extreme environment exposure after pulmonary infection: SCUBA diving as a model? [PDF]

Physiol Rep
Graphical overview of the experimental protocol used to investigate post‐COVID physiological responses during scuba diving at three different depths. Abstract The human body implements several adaptive mechanisms to perform in extreme environments. Increasingly, individuals return to such conditions after pulmonary infections, raising concerns about ...
Cialoni D, Brizzolari A, Mrakic‐Sposta S, Vezzoli A, Dellanoce C, Pieri M, Pelliccia R, Petrassi C, Bosco G, Barassi A, Marroni A.   +10 more
europepmc   +2 more sources

Transition From Juvenile Dermatomyositis to Spondyloarthritis: A Novel Overlapping Inflammatory Phenotype [PDF]

ACR Open Rheumatol
Objective Juvenile dermatomyositis (JDM) is a rare childhood inflammatory myopathy, whereas spondyloarthritis (SpA) is an inflammatory arthropathy characterized by enthesitis and peripheral or axial involvement. We describe a series of patients diagnosed with JDM in childhood who later fulfilled classification criteria for SpA, a sequential phenotype ...
Grooms A, Karageorgiou I, Mychaliska K, Birmingham J.   +3 more
europepmc   +2 more sources

Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients.

PLoS ONE, 2021
Knee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint.
Gregory Baxter-Parker, Lloyd Roffe, Elena Moltchanova, Jay Jefferies, Siddarth Raajasekar, Gary Hooper, Steven P Gieseg   +6 more
doaj   +1 more source

Urinary neopterin concentrations vs total neopterins for clinical utility. [PDF]

Clinical Chemistry, 1989
Abstract Neopterin measurements are especially useful as an early marker in (e.g.) allograft rejections and in patients infected with human immunodeficiency virus type 1 (HIV-1). An increased concentration of total neopterins (neopterin + dihydroneopterin) is also a significant marker in patients with HIV-1 infection.
Fuchs, Dietmar, Milstien, Sheldon, Krämer, Alexander, Reibnegger, Gilbert, Werner, Ernst R., Goedert, James J., Kaufman, Seymour, Wachter, Helmut   +7 more
openaire   +3 more sources