Results 11 to 20 of about 5,716 (181)

Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?

Antioxidants, 2018
Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. However, the analysis of neopterin alone neglects the cellular reactions that generate it in response to ...
Steven P Gieseg, Angus Lindsay
exaly   +3 more sources

Urinary Neopterin in Malignant Lymphoma

The International Journal of Biological Markers, 1991
Urinary neopterin levels were studied in 96 patients with malignant lymphomas. Twenty-eight had Hodgkin's disease and 68 non-Hodgkin's lymphoma. Neopterin excretion was significantly related to the clinical stage of the disease.
L. Piccinini, S. Zironi, M. Federico, L. A. Pini, G. Luppi   +4 more
doaj   +4 more sources

Neopterin measurement in clinical diagnosis [PDF]

Journal of Clinical Pharmacy and Therapeutics, 2001
Neopterin is a marker associated with cell-mediated immunity. It is produced in monocytes/macrophages primarily upon stimulation with interferon-gamma. Due to its chemical structure, neopterin belongs to the class of pteridines. It is excreted in an unchanged form via the kidneys. Serum levels above 10 nmol/L are regarded as elevated.
A, Berdowska, K, Zwirska-Korczala
exaly   +3 more sources

Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients.

PLoS ONE, 2021
Knee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint.
Gregory Baxter-Parker, Lloyd Roffe, Elena Moltchanova, Jay Jefferies, Siddarth Raajasekar, Gary Hooper, Steven P Gieseg   +6 more
doaj   +1 more source

Age-Dependent Variation in Blood Biopterin Peaks Following Oral Tetrahydrobiopterin Administration in Phenylketonuria. [PDF]

J Inherit Metab Dis
ABSTRACT The correct diagnosis of tetrahydrobiopterin (BH4, sapropterin dihydrochloride)‐responsive phenylketonuria (PKU) and treatment with BH4 are important for prognosis and quality of life. We examined whether age affects biopterin bioavailability following oral BH4 administration in PKU and whether this influences BH4 responsiveness.
Kitayama K, Sakaguchi T, Nakano N, Kabata D, Shintaku H, Hamazaki T.   +5 more
europepmc   +2 more sources

Cerebrospinal fluid neopterin analysis in neuropediatric patients: establishment of a new cut off-value for the identification of inflammatory-immune mediated processes. [PDF]

PLoS ONE, 2013
ObjectiveA high level of cerebrospinal fluid (CSF) neopterin is a marker of central nervous system inflammatory-immune mediated processes. We aimed to assess data from 606 neuropediatric patients, describing the clinical and biochemical features of those
Marta Molero-Luis, Sergio Fernández-Ureña, Iolanda Jordán, Mercedes Serrano, Aida Ormazábal, Àngels Garcia-Cazorla, Rafael Artuch, Neopterin Working Group   +7 more
doaj   +1 more source

Neopterin as an endogenous antioxidant [PDF]

FEBS Letters, 1992
The in vitro potency of neopterin (NP) as an antioxidant and its in vivo activity to suppress alloxan‐induced diabetes were investigated. The reduced form of neopterin, 5,6,7,8‐tetrahydroneopterin (NPH‐4), showed an extremely high superoxide anion radical scavenging activity in two assay systems, i.e.
Kojima, Shuji, Icho, Takeshi, Kajiwara, Yoshio, Kubota, Kazuhiko   +3 more
openaire   +2 more sources

Urinary neopterin concentrations vs total neopterins for clinical utility. [PDF]

Clinical Chemistry, 1989
Abstract Neopterin measurements are especially useful as an early marker in (e.g.) allograft rejections and in patients infected with human immunodeficiency virus type 1 (HIV-1). An increased concentration of total neopterins (neopterin + dihydroneopterin) is also a significant marker in patients with HIV-1 infection.
Fuchs, Dietmar, Milstien, Sheldon, Krämer, Alexander, Reibnegger, Gilbert, Werner, Ernst R., Goedert, James J., Kaufman, Seymour, Wachter, Helmut   +7 more
openaire   +3 more sources

Treatment of major depression with sertraline: Relationship between serum neopterin levels and respond to the treatment

Psychiatry and Clinical Psychopharmacology, 2021
Objective: The aim of this study was to examine the activity of immune system in patients with major depression by using serum neopterin levels as a biochemical tool.
Cemil Çelik, Murat Erdem, Barbaros Özdemir, Tuncer Çaycı, Türker Türker, Fuat Özgen   +5 more
doaj  

Serum Neopterin in Patients with Malignant Melanoma

Pteridines, 2009
Increased serum or urinary concentrations of neopterin have been described in patients with tumors of different primary locations, but reports on neopterin in patients with melanoma are scanty. We have studied serum neopterin and a melanoma marker, S-100-
Beneš Petr, Melichar Bohuslav, Študentová Hana, Kapustová Miloslava, Malírová Eva, Schneiderka Petr, Šrámek Vlastislav, Cwiertka Karel   +7 more
doaj   +1 more source