Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing? [PDF]
Antioxidants, 2018 Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. However, the analysis of neopterin alone neglects the cellular reactions that generate it in response to ...
Steven Gieseg +2 more
exaly +6 more sources
Cerebrospinal fluid neopterin analysis in neuropediatric patients: establishment of a new cut off-value for the identification of inflammatory-immune mediated processes. [PDF]
PLoS ONE, 2013 ObjectiveA high level of cerebrospinal fluid (CSF) neopterin is a marker of central nervous system inflammatory-immune mediated processes. We aimed to assess data from 606 neuropediatric patients, describing the clinical and biochemical features of those
Marta Molero-Luis +7 more
doaj +4 more sources
Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients. [PDF]
PLoS ONE, 2021 Knee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint.
Gregory Baxter-Parker +6 more
doaj +2 more sources
Urinary Neopterin in Malignant Lymphoma
The International Journal of Biological Markers, 1991 Urinary neopterin levels were studied in 96 patients with malignant lymphomas. Twenty-eight had Hodgkin's disease and 68 non-Hodgkin's lymphoma. Neopterin excretion was significantly related to the clinical stage of the disease.
L. Piccinini +4 more
doaj +2 more sources
First Synthesis of a Natural Neopterin Glycoside: 3'-O-(β-D-Glucopyranosyluronic acid)neopterin [PDF]
Pteridines, 2010 1',2'-Di-O-acetyl-N2-(N,N-dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]neopterin (1) was prepared from neopterin in 5 steps. Glycosylation of 1 with methyl 2,3,4-tri-O-benzoyl-α-D-glucopyranosyluronate bromide in the presence of silver triflate and ...
Hanaya Tadashi +3 more
doaj +3 more sources
Neopterin Determinations in Tuberculous Bone Infections
Pteridines, 1994 In patients with tuberculous chest infections caused by intracellular Mycobacteria elevated serum neopterin levels could be found. In the present study neopterin levels were elevated in 5/6 patients with proven tuberculous bone infections as well ...
Peters K. M. +3 more
doaj +2 more sources
Clinical Usefulness of Determining the Concentration of Neopterin
Pteridines, 2011 Neopterin is one of biochemical markers of immune activity, which seems to be useful in monitoring inflammatory diseases. Increased serum concentration of neopterin is observed in conditions with cell-mediated immune response involvement.
Plata-Nazar Katarzyna +1 more
doaj +2 more sources
The Effects of Neopterin on the Viability and Motility of Different HCC Cell Lines
Proceedings, 2018 Increased neopterin levels reflect the activation of the cellular immune system which is of importance in the pathogenesis and progression of various diseases such as cancer.
Imge Kunter +4 more
doaj +2 more sources
PteridinesAtherosclerosis is an inflammatory disease where activated immune cells are recruited into the artery wall forming artery plaques. Interferon-γ released by T-cells causes macrophage synthesis and release of 7,8-dihydroneopterin, an antioxidant and CD36 ...
Raajasekar Siddarth +5 more
doaj +2 more sources
Neopterin Counters Vascular Inflammation and Atherosclerosis
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundNeopterin, a metabolite of GTP, is produced by activated macrophages and is abundantly expressed within atherosclerotic lesions in human aorta and carotid and coronary arteries.
Remina Shirai +12 more
doaj +2 more sources