Results 31 to 40 of about 5,734 (184)

Neopterin in Patients with Choroidal Melanoma [PDF]

Clinical Chemistry and Laboratory Medicine, 1993
Neopterin excretion in urine and the serum concentrations of neopterin were compared in 101 patients with a malignant melanoma of the choroid and in a matched group of healthy volunteers. The majority of cases (n = 99) presented an untreated (n = 20) or treated and either partially (n = 33) or completely regressed (n = 47) melanoma of stage I-III ...
Gerding, H., Cremer-Bartels, G., Krause, K., Busse, H.   +3 more
openaire   +2 more sources

Early brain‐penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1‐related Aicardi‐Goutières syndrome

Clinical &Translational Immunology, Volume 15, Issue 7, 2026.
Abstract Objectives Aicardi‐Goutières syndrome (AGS) is a genetic interferonopathy resulting from defects in nucleic acid metabolism and subsequent enhanced type I interferon signalling. We report how an expedited genomic diagnosis in conjunction with natural history data can enable a long‐term brain‐penetrant anti‐inflammatory regimen to optimise ...
Russell C Dale, Jessica Hayes, Velda X Han, Ruwani Dissanayake, Xianzhong Lau, Michelle Farrar, Brian Gloss, Markus Hofer, Esther Tantsis, Michelle Lorentzos, Safiyyah Abbas, Yanick J Crow, Shekeeb Mohammad, Shrujna Patel   +13 more
wiley   +1 more source

Urinary Neopterin in Patients with Diabetes Mellitus and Foot Ulcers

Pteridines, 2007
Increased urinary or serum concentrations of neopterin have been reported in disorders associated with systemic immune activation, e.g. viral infections, cancer, or autoimmune diseases, but the data on neopterin concentrations in patients with diabetes ...
Melicharova Karolina, Kusalova Marie, Smahelova Alena, Hyspler Radomir, Solichova Dagmar, Melichar Bohuslav   +5 more
doaj   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Neopterin Concentrations in Colon Dialysate

Pteridines, 2001
Increased production of neopterin in humans is indicative for an activated cellular immune response. The intestinal immune system encounters an enormous amount of infectious agents or injurious substances evoking a cellular immune response. The objective
Ledjeff E., Artner-Dworzak E., Witasek A., Fuchs D., Hausen A.   +4 more
doaj   +1 more source

The Effects of Neopterin on the Viability and Motility of Different HCC Cell Lines

Proceedings, 2018
Increased neopterin levels reflect the activation of the cellular immune system which is of importance in the pathogenesis and progression of various diseases such as cancer.
Imge Kunter, Marianna Najjar, Yelin Subasi, Niloofar Zabib, Gonul Sahin   +4 more
doaj   +1 more source

An Overview of Pterin Analysis in Biological Samples: From Occurrence and Properties to Sample Pretreatment Combined With Hyphenated Separation Techniques

Journal of Separation Science, Volume 49, Issue 7, July 2026.
ABSTRACT Pterins are a structurally diverse group of biologically active compounds within the pteridine family, with key roles in pigmentation, redox metabolism, light sensing, and cellular signaling across a wide range of organisms. Their quantification in biological samples is analytically demanding due to their high polarity, chemical instability ...
Jindřich Brejcha, Zuzana Bosakova
wiley   +1 more source

Plasma total neopterin and neopterin levels are significantly elevated in stroke patients before carotid endarterectomy surgery

Pteridines
Atherosclerosis is an inflammatory disease where activated immune cells are recruited into the artery wall forming artery plaques. Interferon-γ released by T-cells causes macrophage synthesis and release of 7,8-dihydroneopterin, an antioxidant and CD36 ...
Raajasekar Siddarth, Roake Justin, Cameron Vicky, Benson Ruth, Pilbrow Anna, Gieseg Steven   +5 more
doaj   +1 more source

Dysregulated Metabolism in People Living With HIV in the Modern ART‐Era: A Systematic Review of Targeted Metabolomics Studies

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT HIV remains a significant public health issue, with 1.3 million new infections and 630,000 deaths annually, and 40.8 million people living with HIV (PLHIV) globally in 2024. Although antiretroviral therapy (ART) suppresses viral replication, it does not eradicate the virus, and metabolic dysregulation persists despite treatment.
Levanco K. Asia, Du Toit Loots, Shayne Mason, Esme Jansen Van Vuren, Monray E. Williams   +4 more
wiley   +1 more source

The relationship between plasma level of indoleamine 2,3-dioxygenase and neopterin in patients with depression

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Preliminary results of the study that intended to compare serum indoleamine 2,3-dioxygenase (IDO) and neopterin levels in patients with major depression and the healthy control group is presented.
Adem Balıkcı, Murat Erdem, Abdullah Bolu, Tuncer Çaycı, Emre Aydemir, A. Gazi Ünlü, Emin Özgür Akgül   +6 more
doaj