Crystal structure of 7,8-dihydroneopterin triphosphate epimerase [PDF]
Structure, 1999 Dihydroneopterin triphosphate (H2NTP) is the central substrate in the biosynthesis of folate and tetrahydrobiopterin. Folate serves as a cofactor in amino acid and purine biosynthesis and tetrahydrobiopterin is used as a cofactor in amino acid hydroxylation and nitric oxide synthesis.
Adelbert Bacher, Stefan Steinbacher
exaly +5 more sources
Neopterin and 7,8-dihydroneopterin are generated within atherosclerotic plaques
Pteridines, 2015 Plasma neopterin correlates with the level of cardiovascular disease. Neopterin is the oxidation product of 7,8-dihydroneopterin, which is released by γ-interferon-stimulated macrophages. 7,8-Dihydroneopterin is a potent antioxidant, which inhibits lipid
Steven Gieseg +2 more
exaly +3 more sources
Potential to inhibit growth of atherosclerotic plaque development through modulation of macrophage neopterin/7,8‐dihydroneopterin synthesis [PDF]
British Journal of Pharmacology, 2008 The rise in plasma neopterin observed with increasing severity of vascular disease is a strong indicator of the inflammatory nature of atherosclerosis. Plasma neopterin originates as the oxidation product of 7,8‐dihydroneopterin secreted by γ ‐interferon stimulated macrophages within ...
Zunika Amit +2 more
exaly +5 more sources
Neopterin, the Cell-Mediated Immune Response Biomarker, in Inflammatory Periodontal Diseases: A Narrative Review of a More than Fifty Years Old Biomarker [PDF]
Biomedicines, 2023 Neopterin is a biomarker of the activation of cellular immunity. The purpose of this review is to summarise neopterin metabolism, methods of its detection, and its role in inflammation, focusing on periodontal inflammatory diseases.
Ondrej Heneberk +2 more
doaj +2 more sources
An Overview of Pterin Analysis in Biological Samples: From Occurrence and Properties to Sample Pretreatment Combined With Hyphenated Separation Techniques. [PDF]
J Sep SciABSTRACT Pterins are a structurally diverse group of biologically active compounds within the pteridine family, with key roles in pigmentation, redox metabolism, light sensing, and cellular signaling across a wide range of organisms. Their quantification in biological samples is analytically demanding due to their high polarity, chemical instability ...
Brejcha J, Bosakova Z.
europepmc +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway.
Pablo Machado +2 more
exaly +2 more sources
Study on potential markers for diagnosis of renal cell carcinoma by serum untargeted metabolomics based on UPLC-MS/MS [PDF]
Frontiers in Physiology, 2022 Objective: Renal cell carcinoma (RCC) is the most common malignancy of the kidney. However, there is no reliable biomarker with high sensitivity and specificity for diagnosis and differential diagnosis. This study aims to analyze serum metabolite profile
Jun Wang +7 more
doaj +2 more sources
Untargeted Metabolomic and Lipidomic Profiles of Gingival Crevicular Fluid in the Context of Periodontitis. [PDF]
J Clin PeriodontolABSTRACT Aim(s) This cross‐sectional clinical study aimed to explore the untargeted metabolomic and lipidomic profiles in gingival crevicular fluid (GCF) obtained from healthy individuals and patients with periodontitis. Materials and Methods GCF was collected from 17 periodontally healthy and 19 periodontitis patients.
Henderzahs CH +6 more
europepmc +2 more sources
A systematic review and meta-analysis of neopterin in rheumatic diseases [PDF]
Frontiers in Immunology, 2023 IntroductionNovel biomarkers of inflammation and oxidative stress might enhance the early recognition, management, and clinical outcomes of patients with rheumatic diseases (RDs).
Arduino A. Mangoni +2 more
doaj +2 more sources
Seminal Plasma Metabolomic Profiling Reveals Key Metabolic Signatures Linked to Spermatogenic Potential in Non-Obstructive Azoospermia with Cryptorchidism [PDF]
MetabolitesBackground/Objectives: Cryptorchidism is a common cause of male infertility and often results in azoospermia. However, the metabolic perturbations underlying cryptorchidism complicated with azoospermia and their association with surgical sperm retrieval ...
Jianxing Cheng +7 more
doaj +2 more sources