Neopterin, the Cell-Mediated Immune Response Biomarker, in Inflammatory Periodontal Diseases: A Narrative Review of a More than Fifty Years Old Biomarker [PDF]
Biomedicines, 2023 Neopterin is a biomarker of the activation of cellular immunity. The purpose of this review is to summarise neopterin metabolism, methods of its detection, and its role in inflammation, focusing on periodontal inflammatory diseases.
Ondrej Heneberk +2 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway.
Pablo Machado +2 more
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Study on potential markers for diagnosis of renal cell carcinoma by serum untargeted metabolomics based on UPLC-MS/MS [PDF]
Frontiers in Physiology, 2022 Objective: Renal cell carcinoma (RCC) is the most common malignancy of the kidney. However, there is no reliable biomarker with high sensitivity and specificity for diagnosis and differential diagnosis. This study aims to analyze serum metabolite profile
Jun Wang +7 more
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Seminal Plasma Metabolomic Profiling Reveals Key Metabolic Signatures Linked to Spermatogenic Potential in Non-Obstructive Azoospermia with Cryptorchidism [PDF]
MetabolitesBackground/Objectives: Cryptorchidism is a common cause of male infertility and often results in azoospermia. However, the metabolic perturbations underlying cryptorchidism complicated with azoospermia and their association with surgical sperm retrieval ...
Jianxing Cheng +7 more
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A systematic review and meta-analysis of neopterin in rheumatic diseases [PDF]
Frontiers in Immunology, 2023 IntroductionNovel biomarkers of inflammation and oxidative stress might enhance the early recognition, management, and clinical outcomes of patients with rheumatic diseases (RDs).
Arduino A. Mangoni +2 more
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Neopterin and 7,8-Dihydroneopterin Are Generated Within Atherosclerotic Plaques
Pteridines, 2015 Plasma neopterin correlates with the level of cardiovascular disease. Neopterin is the oxidation product of 7,8-dihydroneopterin, which is released by γ-interferon-stimulated macrophages. 7,8-Dihydroneopterin is a potent antioxidant, which inhibits lipid
Steven Gieseg +2 more
exaly +2 more sources
Integrated metabolome and transcriptome analysis reveals key genes and pathways associated with egg yolk percentage in chicken [PDF]
Poultry ScienceYolk percentage is a critical index in the egg product industry, reflecting both nutritional value and economic benefits. To elucidate the underlying mechanisms that contribute to variations in egg yolk percentage, we performed integrated transcriptome ...
Wen Li +5 more
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Potential to Inhibit Growth of Atherosclerotic Plaque Development Through Modulation of Macrophage Neopterin/7,8-Dihydroneopterin Synthesis [PDF]
British Journal of Pharmacology, 2008 Zunika Amit +2 more
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Biomolecules, 2021 Endometriosis is a benign disease affecting one in ten women of reproductive age worldwide. Although the pain level is not correlated to the extent of the disease, it is still one of the cardinal symptoms strongly affecting the patients’ quality of life.
Benjamin Neuditschko +8 more
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Pteridines, 2020 Introduction: Neopterin and 7,8-dihydroneopterin are used as biomarkers of oxidative stress and inflammation, but the effect of kidney function on these measurements has not been extensively explored.
Baxter-Parker Gregory +6 more
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