Results 31 to 40 of about 808 (137)
Frontiers in Molecular Biosciences, 2020 The de novo folate synthesis pathway is a well-established drug target in the treatment of many infectious diseases. Antimalarial antifolate drugs have proven to be effective against malaria, however, rapid drug resistance has emerged on the two primary ...
Afrah Khairallah +2 more
doaj +1 more source
One‐carbon metabolism, folate, zinc and translation
Microbial Biotechnology, Volume 13, Issue 4, Page 899-925, July 2020., 2020 The translation machinery integrates the metabolism of carbon, nitrogen, sulfur and phospahte via a tight association between one‐carbon metabolism and the zinc divalent ion. Summary The translation process, central to life, is tightly connected to the one‐carbon (1‐C) metabolism via a plethora of macromolecule modifications and specific effectors ...
Antoine Danchin +2 more
wiley +1 more source
Neopterin-induced Suppression of Erythropoietin Production In Vitro
Pteridines, 1995 The production of neopterin increases in several diseases with activation of the ceIlular immune response. As previously shown serum concentrations of neopterin are inversely correlated with blood hemoglobin concentrations in the anemia of hematological ...
Schobersberger W. +5 more
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Pteridines, 2002 Neopterin, 7,8-dihydroneopterin and 5,6,7,8-terahydroneopterm are secreted by human macrophages after activation by interferon-γ. The biological stability of the reduced pterins is less than one hour and therefore distinctly lower than that of neopterin.
Horejsi Renate +3 more
doaj +1 more source
Pteridines, 2015 Cold water immersion is thought to reduce the inflammatory response to injury. Using cultured mononuclear cells and human subjects in a mixed martial arts (MMA) contest, we examined the effect of cryotherapy on 7,8-dihydroneopterin and neopterin ...
Lindsay Angus +7 more
doaj +1 more source
Measurement of changes in urinary neopterin and total neopterin in body builders using SCX HPLC
Pteridines, 2014 Body building is a sport where ultrastructual damage to muscle fibres aids the development of dense muscle layers. Using a new strong cation exchange (SCX) based chromatography technique to measure neopterin and 7,8-dihydroneopterin, we investigated ...
Lindsay Angus +3 more
doaj +1 more source
Pteridines and Lipid Metabolism
Pteridines, 1998 The effect of 9 different pteridines on fatty acid incorporation into phospholipids as well as on cholesterol and phospholipid content was compared in vitro using rat liver homogenate, Krebs-Ringer phosphate buffer containing 0.3 % albumin (pH=7.4 ...
Rudzite Vera +5 more
doaj +1 more source
Auto-oxidation of 5,6,7 ,8-tetrahydroneopterin
Pteridines, 1998 Auto-oxidation of 5,6,7,8-tetrahydroneopterin (NPH4 ) in phosphate buffer solution (PBS) was examined using reversed-phase high-performance liquid chromatography.
Arai Toshiyuki +5 more
doaj +1 more source
Inhibitory Effects of Pteridines on the Cytochrome P-450 Enzyme System
Pteridines, 1997 The effects of 17 different pteridine derivatives on rat liver microsomal cytochrome P-450 catalyzed degradation of aminoantipyrin were studied.
Horejsi Renate +5 more
doaj +1 more source
PteridinesAtherosclerosis is an inflammatory disease where activated immune cells are recruited into the artery wall forming artery plaques. Interferon-γ released by T-cells causes macrophage synthesis and release of 7,8-dihydroneopterin, an antioxidant and CD36 ...
Raajasekar Siddarth +5 more
doaj +1 more source