Results 31 to 40 of about 26,693 (166)

Macrophage mediated protein hydroperoxide formation and lipid oxidation in low density lipoprotein are inhibited by the inflammation marker 7,8-dihydroneopterin [PDF]

, 2008
The formation of oxidised low density lipoprotein (LDL) within the atherosclerotic plaque appears to be a factor in the development of advanced atherosclerotic plaques.
Flavall, Elizabeth A., Crone, Elizabeth M., Firth, Carole A., Gieseg, Steven P., Roake, Justin A.   +4 more
core   +1 more source

Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients.

PLoS ONE, 2021
Knee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint.
Gregory Baxter-Parker, Lloyd Roffe, Elena Moltchanova, Jay Jefferies, Siddarth Raajasekar, Gary Hooper, Steven P Gieseg   +6 more
doaj   +1 more source

Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia based on ethology, energy metabolism, and urine metabolomic approaches

Frontiers in Pharmacology, 2022
Ciwujia Tablets (CWT) are produced by concentrating and drying the extract solution of the dried rhizome of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim [Araliaceae; E. senticosus radix et rhizoma].
Hongda Liu, Le Yang, Chunlei Wan, Zhineng Li, Guangli Yan, Ying Han, Hui Sun, Xijun Wang, Xijun Wang, Xijun Wang   +9 more
doaj   +1 more source

Effect of Neopterin Derivatives on Mitochondrial Dehydrogenase Activity in Ovarian Carcinoma Cell Lines in Vitro

Pteridines, 2006
In a recent study we could show that neopterin inhibits nitric oxide-induced apoptosis in ovarian carcinoma cells. This may provide an explanation for the correlation between increased levels of neopterin derivatives and the unfavorable prognosis in ...
Rieder Josef, Marth Christian, Hoffmann' Georg   +2 more
doaj   +1 more source

OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells [PDF]

, 2005
The atherosclerotic plaque is an inflammatory site where macrophage cells are exposed to cytotoxic oxidised low density lipoprotein (oxLDL). Interferon-γ released from T-cells results in macrophage synthesis of 7,8-dihydroneopterin which has antioxidant ...
Reid, Linzi, Gieseg, Steven P., Baird, Sarah K., Hampton, Mark B.   +3 more
core   +1 more source

One‐carbon metabolism, folate, zinc and translation

Microbial Biotechnology, Volume 13, Issue 4, Page 899-925, July 2020., 2020
The translation machinery integrates the metabolism of carbon, nitrogen, sulfur and phospahte via a tight association between one‐carbon metabolism and the zinc divalent ion. Summary The translation process, central to life, is tightly connected to the one‐carbon (1‐C) metabolism via a plethora of macromolecule modifications and specific effectors ...
Antoine Danchin, Agnieszka Sekowska, Conghui You   +2 more
wiley   +1 more source

Oxidant Production, oxLDL uptake and CD36 levels in Human Monocyte Derived Macrophages are down regulated by the macrophage - generated antioxidant 7,8-dihydroneopterin [PDF]

, 2010
The severity of atheroma burden in patients strongly correlates to increasing levels of plasma neopterin, the oxidation product of 7,8-dihydroneopterin.
Katouah, H., Gieseg, S.P, Zunika, Amit, Shchepetkina, A., Ya, T.Y   +4 more
core   +1 more source

7,8-Dihydroneopterin Upregulates Interferon-γ Promoterin T cells

Immunobiology, 1996
Activated cell-mediated immunity is accompanied by elevated concentrations of interferon-gamma leading to the secretion of neopterin-derivatives which are known as sensitive immune activation markers in clinical laboratory diagnosis. Recent data imply a potential role of neopterin-derivatives in oxygen-free radical-mediated processes and a direct ...
G, Baier-Bitterlich, D, Fuchs, H, Wachter   +2 more
openaire   +2 more sources

Untargeted Metabolomic Profiling Using UHPLC‐QTOF/MS Reveals Metabolic Alterations Associated with Autism

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Autism spectrum disorder (ASD) is a clinical spectrum of neurodevelopment disorder characterized by deficits in social communication and social interaction along with repetitive/stereotyped behaviors. The current diagnosis for autism relies entirely on clinical evaluation and has many limitations.
Yujie Liang, Xiaoyin Ke, Zhou Xiao, Ying Zhang, Yangxia Chen, Yingyuan Li, Zhonglei Wang, Ling Lin, Paul Yao, Jianping Lu, Kazuhisa Nishizawa   +10 more
wiley   +1 more source

Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler

International Journal of Genomics, Volume 2020, Issue 1, 2020., 2020
The antler regeneration has been well studied for the past two decades and adopted in the regenerative medicine model for studying on developmental biology. Despite our growing knowledge of functional molecules regulating antler regeneration, we still do not know whether antler from different deer species possess the exact same mechanism or not.
Hang Su, Chonghui Yang, Chenrong Jin, He Zhang, Chengcheng Yin, Yang Yang, Haoyuan Chen, Li Jing, Bin Qi, Daqing Zhao, Xueyuan Bai, Li Liu, Atsushi Kurabayashi   +12 more
wiley   +1 more source