Results 21 to 30 of about 26,693 (166)

Identification and characterization of new structural scaffolds modulating the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro [PDF]

Frontiers in Tropical Diseases
IntroductionAntifolates were among the first broad-spectrum compounds used as antimycobacterial agents and can still be of use when no other therapeutic options are available.
Virginia Carla de Almeida Falcão, Alexia de Matos Czeczot, Alexia de Matos Czeczot, Mohammad Maqusood Alam, Kyu-Ho Paul Park, Jinyeong Heo, Minjeong Woo, Ana Micaela Camini, Luis Fernando Saraiva Macedo Timmers, Luis Fernando Saraiva Macedo Timmers, Luis Fernando Saraiva Macedo Timmers, David Shum, Marcia Alberton Perelló, Luiz Augusto Basso, Luiz Augusto Basso, Luiz Augusto Basso, Pablo Machado, Pablo Machado, Pablo Machado, Cristiano Valim Bizarro, Cristiano Valim Bizarro, Vincent Delorme   +21 more
doaj   +2 more sources

Reduction of Ferric Iron by 7,8-Dihydroneopterin

Pteridines, 1990
Hausen A., Fuchs D., Fuchs D., Reibnegger G., Werner E. R., Werner-Felmayer G., Wachter H.   +6 more
doaj   +2 more sources

7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathway

European Journal of Cell Biology, 2002
Activated cell-mediated immunity is known to be accompanied by elevated concentrations of 7,8-dihydroneopterin which in high concentrations was found to interfere with the oxidant-antioxidant balance. In this study we investigated whether 7,8-dihydroneopterin mediates apoptosis of Jurkat T-lymphocytes via a CrmA- or Bcl-2-sensitive pathway.
Gottfried Baier, Gabriele Baier-Bitterlich, Dietmar Fuchs   +2 more
exaly   +3 more sources

Inhibition of haemolysis by the macrophage synthesized antioxidant, 7,8-dihydroneopterin [PDF]

Redox Report, 2000
AbstractNeopterin and the reduced form, 7,8-dihydroneopterin (78NP) are pteridines released from macrophages when stimulated with interferon-γ (IFN-γ) in vivo.1,2 The role of 78NP in inflammatory response is unknown, though neopterin has been used clinically as a marker of immune cell activation due to its very fluorescent nature.
Gieseg, S. P., Maghzal, G., Glubb, D.
openaire   +3 more sources

The Structures of the Reoxidation Products of 7,8-Dihydroneopterin [PDF]

Bulletin of the Chemical Society of Japan, 1973
Abstract On the reduction of d-erythro-neopterin with sodium dithionite, after which it was let stand in neutral pH, three colorless compounds, I, II, and III, and two yellow compounds, I and II, were obtained. On the reduction of d-erythro-neopterin with Fe dust in 25% acetic acid, after which it was let stand at a neutral pH, two ...
Katsura Sugiura, Miki Goto
openaire   +1 more source

Mass spectrometry‐based “omics” technologies for the study of gestational diabetes and the discovery of new biomarkers

Mass Spectrometry Reviews, Volume 42, Issue 4, Page 1424-1461, July/August 2023., 2023
Abstract Gestational diabetes (GDM) is one of the most common complications occurring during pregnancy. Diagnosis is performed by oral glucose tolerance test, but harmonized testing methods and thresholds are still lacking worldwide. Short‐term and long‐term effects include obesity, type 2 diabetes, and increased risk of cardiovascular disease.
Marco Roverso, Raghav Dogra, Silvia Visentin, Silvia Pettenuzzo, Luca Cappellin, Paolo Pastore, Sara Bogialli   +6 more
wiley   +1 more source

The Genetic Landscape of Complex Childhood‐Onset Hyperkinetic Movement Disorders

Movement Disorders, Volume 37, Issue 11, Page 2197-2209, November 2022., 2022
ABSTRACT Background and Objective The objective of this study was to better delineate the genetic landscape and key clinical characteristics of complex, early‐onset, monogenic hyperkinetic movement disorders. Methods Patients were recruited from 14 international centers.
Belén Pérez‐Dueñas, Kathleen Gorman, Anna Marcé‐Grau, Juan D. Ortigoza‐Escobar, Alfons Macaya, Federica R. Danti, Katy Barwick, Apostolos Papandreou, Joanne Ng, Esther Meyer, Shekeeb S. Mohammad, Martin Smith, Francesco Muntoni, Pinki Munot, Johanna Uusimaa, Päivi Vieira, Eammon Sheridan, Renzo Guerrini, Jan Cobben, Sanem Yilmaz, Elisa De Grandis, Russell C. Dale, Roser Pons, Kathryn J. Peall, Vincenzo Leuzzi, Manju A. Kurian   +25 more
wiley   +1 more source

Epithelial Cell Line Derived from Endometriotic Lesion Mimics Macrophage Nervous Mechanism of Pain Generation on Proteome and Metabolome Levels

Biomolecules, 2021
Endometriosis is a benign disease affecting one in ten women of reproductive age worldwide. Although the pain level is not correlated to the extent of the disease, it is still one of the cardinal symptoms strongly affecting the patients’ quality of life.
Benjamin Neuditschko, Marlene Leibetseder, Julia Brunmair, Gerhard Hagn, Lukas Skos, Marlene C. Gerner, Samuel M. Meier-Menches, Iveta Yotova, Christopher Gerner   +8 more
doaj   +1 more source

A Shared Prebiotic Formation of Neopterins and Guanine Nucleosides from Pyrimidine Bases

Chemistry – A European Journal, Volume 28, Issue 39, July 11, 2022., 2022
The plausible prebiotic availability of 6‐aminopyrimidines makes the formation of purine nucleosides by Traube reaction an interesting pathway to explore. However, the formation of a pterin ring is the preferred outcome relative to purine nucleoside synthesis, which requires a high sugar excess to be significant.
César Menor‐Salván, Bradley T. Burcar, Marcos Bouza, David M. Fialho, Facundo M. Fernández, Nicholas V. Hud   +5 more
wiley   +1 more source

Cerebrospinal fluid metabolomics: detection of neuroinflammation in human central nervous system disease

Clinical &Translational Immunology, Volume 10, Issue 8, 2021., 2021
In this review, we summarise the current human evidence of the use of cerebrospinal fluid metabolomics to detect neuroinflammation in acute and chronic neurological and psychiatric diseases. The review highlights the potential utility of metabolites involved in the tryptophan–kynurenine and nitric oxide pathway and neopterin as biomarkers for ...
Jingya Yan, Unnikrishnan Kuzhiumparambil, Sushil Bandodkar, Russell C Dale, Shanlin Fu   +4 more
wiley   +1 more source