Results 21 to 30 of about 808 (137)

Mass spectrometry‐based “omics” technologies for the study of gestational diabetes and the discovery of new biomarkers

Mass Spectrometry Reviews, Volume 42, Issue 4, Page 1424-1461, July/August 2023., 2023
Abstract Gestational diabetes (GDM) is one of the most common complications occurring during pregnancy. Diagnosis is performed by oral glucose tolerance test, but harmonized testing methods and thresholds are still lacking worldwide. Short‐term and long‐term effects include obesity, type 2 diabetes, and increased risk of cardiovascular disease.
Marco Roverso, Raghav Dogra, Silvia Visentin, Silvia Pettenuzzo, Luca Cappellin, Paolo Pastore, Sara Bogialli   +6 more
wiley   +1 more source

The Genetic Landscape of Complex Childhood‐Onset Hyperkinetic Movement Disorders

Movement Disorders, Volume 37, Issue 11, Page 2197-2209, November 2022., 2022
ABSTRACT Background and Objective The objective of this study was to better delineate the genetic landscape and key clinical characteristics of complex, early‐onset, monogenic hyperkinetic movement disorders. Methods Patients were recruited from 14 international centers.
Belén Pérez‐Dueñas, Kathleen Gorman, Anna Marcé‐Grau, Juan D. Ortigoza‐Escobar, Alfons Macaya, Federica R. Danti, Katy Barwick, Apostolos Papandreou, Joanne Ng, Esther Meyer, Shekeeb S. Mohammad, Martin Smith, Francesco Muntoni, Pinki Munot, Johanna Uusimaa, Päivi Vieira, Eammon Sheridan, Renzo Guerrini, Jan Cobben, Sanem Yilmaz, Elisa De Grandis, Russell C. Dale, Roser Pons, Kathryn J. Peall, Vincenzo Leuzzi, Manju A. Kurian   +25 more
wiley   +1 more source

A Shared Prebiotic Formation of Neopterins and Guanine Nucleosides from Pyrimidine Bases

Chemistry – A European Journal, Volume 28, Issue 39, July 11, 2022., 2022
The plausible prebiotic availability of 6‐aminopyrimidines makes the formation of purine nucleosides by Traube reaction an interesting pathway to explore. However, the formation of a pterin ring is the preferred outcome relative to purine nucleoside synthesis, which requires a high sugar excess to be significant.
César Menor‐Salván, Bradley T. Burcar, Marcos Bouza, David M. Fialho, Facundo M. Fernández, Nicholas V. Hud   +5 more
wiley   +1 more source

Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?

Antioxidants, 2018
Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. However, the analysis of neopterin alone neglects the cellular reactions that generate it in response to ...
Steven P. Gieseg, Gregory Baxter-Parker, Angus Lindsay   +2 more
doaj   +1 more source

Cerebrospinal fluid metabolomics: detection of neuroinflammation in human central nervous system disease

Clinical &Translational Immunology, Volume 10, Issue 8, 2021., 2021
In this review, we summarise the current human evidence of the use of cerebrospinal fluid metabolomics to detect neuroinflammation in acute and chronic neurological and psychiatric diseases. The review highlights the potential utility of metabolites involved in the tryptophan–kynurenine and nitric oxide pathway and neopterin as biomarkers for ...
Jingya Yan, Unnikrishnan Kuzhiumparambil, Sushil Bandodkar, Russell C Dale, Shanlin Fu   +4 more
wiley   +1 more source

Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients.

PLoS ONE, 2021
Knee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint.
Gregory Baxter-Parker, Lloyd Roffe, Elena Moltchanova, Jay Jefferies, Siddarth Raajasekar, Gary Hooper, Steven P Gieseg   +6 more
doaj   +1 more source

Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia based on ethology, energy metabolism, and urine metabolomic approaches

Frontiers in Pharmacology, 2022
Ciwujia Tablets (CWT) are produced by concentrating and drying the extract solution of the dried rhizome of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim [Araliaceae; E. senticosus radix et rhizoma].
Hongda Liu, Le Yang, Chunlei Wan, Zhineng Li, Guangli Yan, Ying Han, Hui Sun, Xijun Wang, Xijun Wang, Xijun Wang   +9 more
doaj   +1 more source

Effect of Neopterin Derivatives on Mitochondrial Dehydrogenase Activity in Ovarian Carcinoma Cell Lines in Vitro

Pteridines, 2006
In a recent study we could show that neopterin inhibits nitric oxide-induced apoptosis in ovarian carcinoma cells. This may provide an explanation for the correlation between increased levels of neopterin derivatives and the unfavorable prognosis in ...
Rieder Josef, Marth Christian, Hoffmann' Georg   +2 more
doaj   +1 more source

Inhibition of protein oxidation by the macrophage-synthesised antioxidant 7,8-dihydroneopterin

Redox Report, 2001
Protein is the pivotal component involved in most cellular activities. As the most abundant cellular molecule, it is the most likely target of any reactive oxygen species (ROS).1 Often considered to be a passive target during free radical exposure, there is now considerable evidence showing ROS damage to proteins leads to the formation of reactive ...
S, Duggan, C, Rait, J M, Gebicki, S P, Gieseg   +3 more
openaire   +2 more sources

7,8-Dihydroneopterin Upregulates Interferon-γ Promoterin T cells

Immunobiology, 1996
Activated cell-mediated immunity is accompanied by elevated concentrations of interferon-gamma leading to the secretion of neopterin-derivatives which are known as sensitive immune activation markers in clinical laboratory diagnosis. Recent data imply a potential role of neopterin-derivatives in oxygen-free radical-mediated processes and a direct ...
G, Baier-Bitterlich, D, Fuchs, H, Wachter   +2 more
openaire   +2 more sources