Results 41 to 50 of about 808 (137)

Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes

BMC Cardiovascular Disorders, 2018
Background Development of collateral circulation in coronary artery disease is cardio-protective. A key process in forming new blood vessels is attraction to occluded arteries of monocytes with their subsequent activation as macrophages. In patients from
Edward C. A. Marks, Tom M. Wilkinson, Chris M. Frampton, Lorraine Skelton, Anna P. Pilbrow, Tim G. Yandle, Chris J. Pemberton, Robert N. Doughty, Gillian A. Whalley, Chris J. Ellis, Richard W. Troughton, Maurice C. Owen, Neil R. Pattinson, Vicky A. Cameron, A. Mark Richards, Steven P. Gieseg, Barry R. Palmer   +16 more
doaj   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

Advanced Science, Volume 12, Issue 42, November 13, 2025.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian, Wenzhu Guo, Yanjing Wang, Weiwei Wen, Weixuan Wang, Ling Jiang, Qiuju Liang, Ji'an Liu, Haijun Liu, Yuan Xue, Lixu Pan, Qiaoquan Liu, Ping Yin, Delin Zhang, Jianbing Yan, Chunyi Zhang   +15 more
wiley   +1 more source

Probiotic characteristics and whole genome sequence analysis of Lactiplantibacillus plantarum ZFM518 isolated from infant feces

Food Frontiers, Volume 5, Issue 5, Page 2235-2248, September 2024.
In vitro characterization of LAB probiotics. One of the most promising probiotics was selected. Analysis of molecular biological information of screened strains by whole‐gene sequencing. Abstract Emerging research has shown that lactic acid bacteria in the intestines of newborns play a beneficial role in the growth, immune function, and metabolism of ...
Yingjuan Zhang, Qingqing Zhou, Ziqi Chen, Zhongdu Ye, Ying Jin, Ping Li, Qing Gu   +6 more
wiley   +1 more source

Formate‐tetrahydrofolate ligase: supplying the cytosolic one‐carbon network in roots with one‐carbon units originating from glycolate

The Plant Journal, Volume 119, Issue 5, Page 2464-2483, September 2024.
SUMMARY The metabolism of tetrahydrofolate (H4PteGlun)‐bound one‐carbon (C1) units (C1 metabolism) is multifaceted and required for plant growth, but it is unclear what of many possible synthesis pathways provide C1 units in specific organelles and tissues.
Sompop Saeheng, Clayton Bailes, Han Bao, Kelem Gashu, Matt Morency, Tana Arlynn, Andrei Smertenko, Berkley James Walker, Sanja Roje   +8 more
wiley   +1 more source

Transcriptome and proteome changes triggered by overexpression of the transcriptional regulator Maf1 in the human pathogen Leishmania major

The FASEB Journal, Volume 38, Issue 16, 31 August 2024.
The transcriptome and proteome changes caused by the overexpression of Maf1 in the protozoan parasite Leishmania major suggest the participation of this protein in multiple key biological processes. Abstract Maf1, originally described as a repressor of RNA polymerase III (RNAP III) transcription in yeast, participates in multiple functions across ...
Luis A. Rivera‐Rivas, Luis E. Florencio‐Martínez, Gabriela Romero‐Meza, Roberto C. Ortega‐Ortiz, Rebeca G. Manning‐Cela, Julio C. Carrero, Tomás Nepomuceno‐Mejía, Santiago Martínez‐Calvillo   +7 more
wiley   +1 more source

Identification and characterization of new structural scaffolds modulating the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro

Frontiers in Tropical Diseases
IntroductionAntifolates were among the first broad-spectrum compounds used as antimycobacterial agents and can still be of use when no other therapeutic options are available.
Virginia Carla de Almeida Falcão, Alexia de Matos Czeczot, Alexia de Matos Czeczot, Mohammad Maqusood Alam, Kyu-Ho Paul Park, Jinyeong Heo, Minjeong Woo, Ana Micaela Camini, Luis Fernando Saraiva Macedo Timmers, Luis Fernando Saraiva Macedo Timmers, Luis Fernando Saraiva Macedo Timmers, David Shum, Marcia Alberton Perelló, Luiz Augusto Basso, Luiz Augusto Basso, Luiz Augusto Basso, Pablo Machado, Pablo Machado, Pablo Machado, Cristiano Valim Bizarro, Cristiano Valim Bizarro, Vincent Delorme   +21 more
doaj   +1 more source

The radical impact of oxygen on prokaryotic evolution—enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third

FEBS Letters, Volume 598, Issue 14, Page 1692-1714, July 2024.
Traditional views of oxygen's role in evolution focus on improved energy yield in heterotrophic pathways. Before respiratory terminal oxidases arose, however, oxygen potently inhibited anaerobic growth, often by degrading FeS clusters. Several pathways for essential cofactors include enzymes with FeS clusters, selecting for alternative, oxygen‐tolerant
Natalia Mrnjavac, Falk S. P. Nagies, Jessica L. E. Wimmer, Nils Kapust, Michael R. Knopp, Katharina Trost, Luca Modjewski, Nico Bremer, Marek Mentel, Mauro Degli Esposti, Itzhak Mizrahi, John F. Allen, William F. Martin   +12 more
wiley   +1 more source

Synthesis of queuine by colonic gut microbiome via cross‐feeding

Food Frontiers, Volume 5, Issue 1, Page 174-187, January 2024.
Escherichia coli, Bacteroides fragilis, and Lactobacillus reuteri could independently synthesize Que in vitro. Abundance of Limosilactobacillus, Pediococcus, and Lactobacillus was increased by Que. Distribution of TGT, QueA, and QueG in microorganisms was changed by Que and bacteria.
Fujie Yan, Shasha Xiang, Lihua Shi, Xuan Zhu   +3 more
wiley   +1 more source

Gene therapy for neurotransmitter‐related disorders

Journal of Inherited Metabolic Disease, Volume 47, Issue 1, Page 176-191, January 2024.
Abstract Inborn errors of neurotransmitter (NT) metabolism are a group of rare, heterogenous diseases with predominant neurological features, such as movement disorders, autonomic dysfunction, and developmental delay. Clinical overlap with other disorders has led to delayed diagnosis and treatment, and some conditions are refractory to oral ...
Wing Sum Chu, Joanne Ng, Simon N. Waddington, Manju A. Kurian   +3 more
wiley   +1 more source