Results 61 to 70 of about 26,693 (166)

The radical impact of oxygen on prokaryotic evolution—enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third

FEBS Letters, Volume 598, Issue 14, Page 1692-1714, July 2024.
Traditional views of oxygen's role in evolution focus on improved energy yield in heterotrophic pathways. Before respiratory terminal oxidases arose, however, oxygen potently inhibited anaerobic growth, often by degrading FeS clusters. Several pathways for essential cofactors include enzymes with FeS clusters, selecting for alternative, oxygen‐tolerant
Natalia Mrnjavac, Falk S. P. Nagies, Jessica L. E. Wimmer, Nils Kapust, Michael R. Knopp, Katharina Trost, Luca Modjewski, Nico Bremer, Marek Mentel, Mauro Degli Esposti, Itzhak Mizrahi, John F. Allen, William F. Martin   +12 more
wiley   +1 more source

Synthesis of queuine by colonic gut microbiome via cross‐feeding

Food Frontiers, Volume 5, Issue 1, Page 174-187, January 2024.
Escherichia coli, Bacteroides fragilis, and Lactobacillus reuteri could independently synthesize Que in vitro. Abundance of Limosilactobacillus, Pediococcus, and Lactobacillus was increased by Que. Distribution of TGT, QueA, and QueG in microorganisms was changed by Que and bacteria.
Fujie Yan, Shasha Xiang, Lihua Shi, Xuan Zhu   +3 more
wiley   +1 more source

Gene therapy for neurotransmitter‐related disorders

Journal of Inherited Metabolic Disease, Volume 47, Issue 1, Page 176-191, January 2024.
Abstract Inborn errors of neurotransmitter (NT) metabolism are a group of rare, heterogenous diseases with predominant neurological features, such as movement disorders, autonomic dysfunction, and developmental delay. Clinical overlap with other disorders has led to delayed diagnosis and treatment, and some conditions are refractory to oral ...
Wing Sum Chu, Joanne Ng, Simon N. Waddington, Manju A. Kurian   +3 more
wiley   +1 more source

Mechanism of oxLDL causing CHOP activation during ER stress and its inhibition by macrophage antioxidant 7,8-dihydroneopterin in U937 cells [PDF]

, 2018
Endoplasmic Reticulum stress (ER) and oxidative stress are two related processes which can cause the death of macrophages within the artery wall. Atherosclerosis is a chronic inflammatory disease caused by the abnormal deposition of cholesterol ester ...
Balpande, Anurup
core   +1 more source

New aspects in biopterin biosynthesis in man [PDF]

, 1981
Tetrahydrobiopterin is synthesized from guanosine triphosphate (GTP)in several enzymatic steps [1,2]. Details of the pathway of the biopterin biosynthesis in mammals are still unresolved [3].
M. Häusermann, Ghisla, S., S. Ghisla, Häusermann, M., H.-Ch. Curtius, Curtius, Hans-Christoph, Curtius, H.-Ch., Häusermann, Max, Niederwieser, A., Niederwieser, Alois, Ghisla, Sandro, A. Niederwieser   +11 more
core   +1 more source

Neopterin derivatives together with cyclic guanosine monophosphate induce c-fos gene expression [PDF]

, 1994
We have previously shown that neopterin enhances hydrogen peroxide and chloramine T activity in a luminol-dependent chemiluminescence assay and strengthens toxicity of these agents against bacteria at slightly alkaline pH (pH 7.5), while 7,8 ...
Grunicke, Hans H., Fuchs, Dietmar, Überall, Florian, Schubert, Christian, Hans H. Grunicke, Werner-Felmayer, Gabriele, Helmut Wachter, Wachter, Helmut, Dietmar Fuchs, Gabriele Werner-Felmayer, Florian Überall, Christian Schubert   +11 more
core   +1 more source

Biosynthesis of tetrahydrofolate in plants: Crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class

, 2004
Dihydroneopterin aldolase (DHNA) catalyses a retroaldol reaction yielding 6-hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin, tetrahydrofolate. The enzyme is a potential target for antimicrobial and anti-parasite chemotherapy.
Illarionova, V., Fischer, M., Bauer, Stefanie, Huber, Robert, Bauer, S., Illarionova, Victoria, Bacher, Adelbert, Schott, A. K., Bacher, A., Fischer, Markus, Huber, R., Schott, Ann-Kathrin   +11 more
core   +1 more source

Atherosclerotic plaque biochemistry and MARS spectral imaging. [PDF]

, 2018
This thesis reports on the use of neopterin and 7,8-dihydroneopterin as biomarkers of inflammation in advanced atherosclerosis and the use of spectral CT imaging to assess the features and morphology of vulnerable atherosclerotic plaque. New non-invasive
Prebble, H. M.
core   +1 more source

Crystal Structure of the Bifunctional Dihydroneopterin Aldolase/6-hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Streptococcus pneumoniae

, 2006
The enzymes dihydroneopterin aldolase (DHNA) and 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) catalyse two consecutive steps in the biosynthesis of folic acid.
Levy, Colin; id_orcid, Garçon, Arnaud, Derrick, Jeremy P.   +2 more
core   +1 more source

Genetic and biotechnological characterization of folate-producing probiotics isolated from local dairy products

Beni-Suef University Journal of Basic and Applied Sciences
Background Folate is essential for Deoxyribonucleic acid (DNA) synthesis, methylation and repair, with deficiencies linked to neural tube defects, Alzheimer’s, and cancer.
Rahma Ali Hassan Abubakr, Mohammed Hassan Abdel A’al, Gihan Mohamed El Moghazy, Ashraf Bakry Abd Elrazik, Samir Abdel Aziz Ibrahim   +4 more
doaj   +1 more source