Results 71 to 80 of about 26,693 (166)

Macrophage Activation and Differentiation with Cholesterol Crystals [PDF]

, 2012
Cholesterol crystals have been linked to activation of the NLRP3 inflammasome and the formation of foreign body giant cells (FBGCs). It has been hypothesized that FBGCs have a role in advanced atherosclerotic plaque formation. This thesis examined the
Burrowes, Hannah Mahony
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Biosynthesis of folic acid.

, 2013
Metabolites - I: Guanosine 5'-triphosphate; II: 7,8-Dihydroneopterin 3'-triphosphate; III: Dihydroneopterin; IV: 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine; V: 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine; VI: para ...
Maria Cristina M. Motta (373824), Myrna G. Serrano (210460), Gregory A. Buck (184803), Cecilia C. Klein (486784), Erney P. Camargo (210465), Marie-France Sagot (69244), João M. P. Alves (210449), Marta M. G. Teixeira (209899), Ana Tereza R. Vasconcelos (123140)   +8 more
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Characterization and reactivity of photodimers of dihydroneopterin and dihydrobiopterin [PDF]

, 2012
7,8-Dihydrobiopterin (H2Bip) and 7,8-dihydroneopterin (H2Nep) belong to a class of heterocyclic compounds present in a wide range of living systems. H2Bip accumulates in the skin of patients suffering from vitiligo, whereas H2Nep is secreted by human ...
Thomas, Andrés, Franco M. Cabrerizo, Thomas, Andrés Héctor, Oliveros, Esther, Erra-Balsells, Rosa, Erra Balsells, Rosa, Esther Oliveros, Carolina Lorente, Andrés H. Thomas, Rosa Erra-Balsells, Cabrerizo, Franco Martín, Lorente, Carolina, Mariana Vignoni, Cabrerizo, Franco, Vignoni, Mariana   +14 more
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Biosynthesis of tetrahydrobiopterin : purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver

, 1986
6-Pyruvoyl-tetrahydropterin synthase, which catalyzes the first step in the conversion of 7,8-dihydroneopterin triphosphate to tetrahydrobiopterin, was purified approximately 140,000-fold to apparent homogeneity from human liver.
Hans-Christoph CURTIUS, Redweik, Udo, Udo REDWEIK, Walter LEIMBACHER, Curtius, Hans-Christoph, Leimbacher, Walter, Sandro GHISLA, Ghisla, Sandro, Shin-Ichiro TAKIKAWA, Takikawa, Shin-Ichiro   +9 more
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Structure and Function of the E. coli Dihydroneopterin Triphosphate Pyrophosphatase: A Nudix Enzyme Involved in Folate Biosynthesis [PDF]

, 2007
SummaryNudix hydrolases are a superfamily of pyrophosphatases, most of which are involved in clearing the cell of potentially deleterious metabolites and in preventing the accumulation of metabolic intermediates.
Bessman, Maurice J., Dunn, Christopher A., Bianchet, Mario A., Niu, Zhi-Dian, Xu, WenLian, Gabelli, Sandra B., Amzel, L. Mario   +6 more
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A Study of Oxidation and Inflammation using Plaque and Plasma of Vascular Disease Patients [PDF]

, 2010
Atherosclerosis is a chronic inflammatory disease leading to the formation of vascular plaques within the major arteries. Vascular plaques consist of a collection of inflammatory cells, extracellular matrix and fibrous material.
Genet, Rebecca May
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The plant Nudix hydrolase family. [PDF]

, 2008
Nudix hydrolases are a family of proteins defined by a conserved amino-acid sequence GX(5)-EX(7)REUXEEXGU, where U is a hydrophobic residue. These enzymes are widely distributed among all classes of organisms and catalyze, with varying degrees of ...
Kraszewska, Elzbieta
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6-Pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria

, 2009
Dihydroneopterin aldolase (FolB) catalyzes conversion of dihydroneopterin to 6-hydroxymethyldihydropterin (HMDHP) in the classical folate biosynthesis pathway.
Lara-Núñez, Aurora, Ziemak, Michael J., Hyde, John E., Hanson, Andrew D., De Crécy-Lagard, Valérie, Jeanguenin, Linda, Pribat, Anne   +6 more
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Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization

, 2016
Potent inhibitors of 7,8-dihydroneopterin aldolase (DHNA; EC 4.1.2.25) have been discovered using CrystaLEAD X-ray crystallographic high-throughput screening followed by structure-directed optimization.
Stephen F. Betz (2514379), Claude G. Lerner (2695870), Bruce A. Beutel (2501500), Geoffrey F. Stamper (2721505), Clarissa G. Jakob (1671439), Karl A. Walter (2463160), J. Owen McCall (2721496), Rolf Wagner (29866), Vincent S. Stoll (2486569), John E. Harlan (1993078), Vicki L. Nienaber (2721502), Jean M. Severin (2463175), Susan J. Swanson (2721508), Sean M. Merrick (2721499), Robert P. Meadows (2709463), William J. Sanders (374703), Kevin R. Condroski (1706482), Peter Magdalinos (2721493)   +17 more
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Comparative Genomics Guided Discovery of Two Missing Archaeal Enzyme Families Involved in the Biosynthesis of the Pterin Moiety of Tetrahydromethanopterin and Tetrahydrofolate

, 2015
C-1 carriers are essential cofactors in all domains of life, and in Archaea, these can be derivatives of tetrahydromethanopterin (H4-MPT) or tetrahydrofolate (H4-folate).
Basma El Yacoubi (1290405), Michael W. W. Adams (22997), Gabriela Phillips (1290411), Robert H. White (1290399), Laura L. Grochowski (1290396), Francis Jenney (1290414), Alexey G. Murzin (1290408), Valérie de Crécy-Lagard (1290402)   +7 more
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