Results 51 to 60 of about 26,693 (166)

Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients. [PDF]

, 2010
Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at which stage of the disease this phenomenon occurs. In the examined groups of patients with colorectal cancer (CRC, n = 89), benign adenoma (AD, n = 77) and ...
Swoboda, Maja, Guz, Jolanta, Speina, Elzbieta, Oliński, Ryszard, Janowska, Beata, Obtułowicz, Tomasz, Janik, Justyna, Dziaman, Tomasz, Szpila, Anna, Siomek, Agnieszka, Cieśla, Jarosław M., Jawien, Arkadiusz, Gackowski, Daniel, Rozalski, Rafał, Tudek, Barbara, Banaszkiewicz, Zbigniew   +15 more
core   +2 more sources

A Point Mutation Converts Dihydroneopterin Aldolase to a Cofactor-Independent Oxygenase

, 2016
Dihydroneopterin aldolase (DHNA) catalyzes the conversion of 7,8-dihydroneopterin (1) to 6-hydroxymethyl-7,8-dihydropterin (4) in the folate biosynthetic pathway.
A. Daniel Jones (145424), Gavin E. Reid (286739), Kade D. Roberts (1315629), Yi Wang (32470), Gwynyth Scherperel (2524738), Honggao Yan (1487260)   +5 more
core   +2 more sources

Plasma total neopterin and neopterin levels are significantly elevated in stroke patients before carotid endarterectomy surgery

Pteridines
Atherosclerosis is an inflammatory disease where activated immune cells are recruited into the artery wall forming artery plaques. Interferon-γ released by T-cells causes macrophage synthesis and release of 7,8-dihydroneopterin, an antioxidant and CD36 ...
Raajasekar Siddarth, Roake Justin, Cameron Vicky, Benson Ruth, Pilbrow Anna, Gieseg Steven   +5 more
doaj   +1 more source

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

Advanced Science, Volume 12, Issue 42, November 13, 2025.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian, Wenzhu Guo, Yanjing Wang, Weiwei Wen, Weixuan Wang, Ling Jiang, Qiuju Liang, Ji'an Liu, Haijun Liu, Yuan Xue, Lixu Pan, Qiaoquan Liu, Ping Yin, Delin Zhang, Jianbing Yan, Chunyi Zhang   +15 more
wiley   +1 more source

Induction of the innate immune response by physical trauma and infection : quantification through analysis of biochemical markers. [PDF]

, 2019
Physical trauma and infection have been shown to be significant stimuli for up-regulation of the human innate immune response, which leads to the production of two commonly used biomarkers; 7,8-dihydroneopterin and neopterin. 7,8-Dihydroneopterin is an
Baxter-Parker, Gregory
core   +1 more source

Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes

BMC Cardiovascular Disorders, 2018
Background Development of collateral circulation in coronary artery disease is cardio-protective. A key process in forming new blood vessels is attraction to occluded arteries of monocytes with their subsequent activation as macrophages. In patients from
Edward C. A. Marks, Tom M. Wilkinson, Chris M. Frampton, Lorraine Skelton, Anna P. Pilbrow, Tim G. Yandle, Chris J. Pemberton, Robert N. Doughty, Gillian A. Whalley, Chris J. Ellis, Richard W. Troughton, Maurice C. Owen, Neil R. Pattinson, Vicky A. Cameron, A. Mark Richards, Steven P. Gieseg, Barry R. Palmer   +16 more
doaj   +1 more source

A model of complex plaque formation: 7,8-Dihydroneopterin protects human monocyte-derived macrophages from oxidised low density lipoprotein-induced death [PDF]

, 2008
Plasma neopterin is an excellent marker of inflammation and is found in elevated levels in plasma of patients with cardiovascular disease. Neopterin originates as the oxidation product of 7,8-dihydroneopterin (7,8-NP), which is secreted by human ...
Amit, Zunika
core   +1 more source

Probiotic characteristics and whole genome sequence analysis of Lactiplantibacillus plantarum ZFM518 isolated from infant feces

Food Frontiers, Volume 5, Issue 5, Page 2235-2248, September 2024.
In vitro characterization of LAB probiotics. One of the most promising probiotics was selected. Analysis of molecular biological information of screened strains by whole‐gene sequencing. Abstract Emerging research has shown that lactic acid bacteria in the intestines of newborns play a beneficial role in the growth, immune function, and metabolism of ...
Yingjuan Zhang, Qingqing Zhou, Ziqi Chen, Zhongdu Ye, Ying Jin, Ping Li, Qing Gu   +6 more
wiley   +1 more source

Formate‐tetrahydrofolate ligase: supplying the cytosolic one‐carbon network in roots with one‐carbon units originating from glycolate

The Plant Journal, Volume 119, Issue 5, Page 2464-2483, September 2024.
SUMMARY The metabolism of tetrahydrofolate (H4PteGlun)‐bound one‐carbon (C1) units (C1 metabolism) is multifaceted and required for plant growth, but it is unclear what of many possible synthesis pathways provide C1 units in specific organelles and tissues.
Sompop Saeheng, Clayton Bailes, Han Bao, Kelem Gashu, Matt Morency, Tana Arlynn, Andrei Smertenko, Berkley James Walker, Sanja Roje   +8 more
wiley   +1 more source

Transcriptome and proteome changes triggered by overexpression of the transcriptional regulator Maf1 in the human pathogen Leishmania major

The FASEB Journal, Volume 38, Issue 16, 31 August 2024.
The transcriptome and proteome changes caused by the overexpression of Maf1 in the protozoan parasite Leishmania major suggest the participation of this protein in multiple key biological processes. Abstract Maf1, originally described as a repressor of RNA polymerase III (RNAP III) transcription in yeast, participates in multiple functions across ...
Luis A. Rivera‐Rivas, Luis E. Florencio‐Martínez, Gabriela Romero‐Meza, Roberto C. Ortega‐Ortiz, Rebeca G. Manning‐Cela, Julio C. Carrero, Tomás Nepomuceno‐Mejía, Santiago Martínez‐Calvillo   +7 more
wiley   +1 more source