Effect of 7,8 -Dihydroneopterin, Biopterin and Isoxanthopterin on Cholesterol and Phospholipid Content and Phospholipid Biosynthesis in Vitro [PDF]
Pteridines, 1996 Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate (Krebs-Ringer-phosphate buffer, pH=7.4, containing 0.3% albumin, fatty acid mixture and glycerol). The addition of 7,8-dihydroneopterin and
Rudzite Vera +4 more
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Pteridines, 2002 The influence of dihydroneopterin on tyrosine hydroxylase activity in PC 12 cells was investigated under normoxic and hyperoxic conditions, and with or without iron ions in the incubation medium.
Vrecko Karoline, Reibnegger Gilbert
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Unveiling the Complete Biosynthetic Pathway of Azacitidine: A Rare 1,3,5-Triazine Nucleoside Derived From GTP. [PDF]
Angew Chem Int Ed EnglThe azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Wang D +6 more
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Reduction of Ferric Iron by 7,8-Dihydroneopterin
Pteridines, 1990 Hausen A. +6 more
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QueF nitrile reductases: Catalytic mechanism and advances in biocatalyst development. [PDF]
Protein SciAbstract Nitrile‐to‐amine reduction is a key transformation in organic and industrial synthesis, providing access to pharmaceutical, agrochemical, and materials manufacturing relevant primary amines. QueF nitrile reductases represent a unique class of biocatalysts capable of catalyzing the NAD(P)H‐dependent four‐electron reduction of nitriles under ...
Li C +4 more
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An Overview of Pterin Analysis in Biological Samples: From Occurrence and Properties to Sample Pretreatment Combined With Hyphenated Separation Techniques. [PDF]
J Sep SciABSTRACT Pterins are a structurally diverse group of biologically active compounds within the pteridine family, with key roles in pigmentation, redox metabolism, light sensing, and cellular signaling across a wide range of organisms. Their quantification in biological samples is analytically demanding due to their high polarity, chemical instability ...
Brejcha J, Bosakova Z.
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Untargeted Metabolomic and Lipidomic Profiles of Gingival Crevicular Fluid in the Context of Periodontitis. [PDF]
J Clin PeriodontolABSTRACT Aim(s) This cross‐sectional clinical study aimed to explore the untargeted metabolomic and lipidomic profiles in gingival crevicular fluid (GCF) obtained from healthy individuals and patients with periodontitis. Materials and Methods GCF was collected from 17 periodontally healthy and 19 periodontitis patients.
Henderzahs CH +6 more
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Inhibition of haemolysis by the macrophage synthesized antioxidant, 7,8-dihydroneopterin [PDF]
Redox Report, 2000 AbstractNeopterin and the reduced form, 7,8-dihydroneopterin (78NP) are pteridines released from macrophages when stimulated with interferon-γ (IFN-γ) in vivo.1,2 The role of 78NP in inflammatory response is unknown, though neopterin has been used clinically as a marker of immune cell activation due to its very fluorescent nature.
Gieseg, S. P., Maghzal, G., Glubb, D.
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The Structures of the Reoxidation Products of 7,8-Dihydroneopterin [PDF]
Bulletin of the Chemical Society of Japan, 1973 Abstract On the reduction of d-erythro-neopterin with sodium dithionite, after which it was let stand in neutral pH, three colorless compounds, I, II, and III, and two yellow compounds, I and II, were obtained. On the reduction of d-erythro-neopterin with Fe dust in 25% acetic acid, after which it was let stand at a neutral pH, two ...
Katsura Sugiura, Miki Goto
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Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild. [PDF]
Am J PrimatolNeopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Behringer V, Deimel C.
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