Neopterin and 7,8‐dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2 [PDF]
FEBS Letters, 1996 The neopterin derivatives, neopterin and 7,8‐dihydroneopterin, modulate the cellular oxidant‐antioxidant balance as well as the expression of the inducible nitric oxide synthase (iNOS) gene. Since apoptosis can be induced by reactive oxygen intermediates and nitric oxide (NO) we investigated whether these neopterin derivatives induce apoptotic cell ...
Dietmar Fuchs, G Böck, B Wirleitner
exaly +5 more sources
Pteridines, 2002 The influence of dihydroneopterin on tyrosine hydroxylase activity in PC 12 cells was investigated under normoxic and hyperoxic conditions, and with or without iron ions in the incubation medium.
Vrecko Karoline, Reibnegger Gilbert
doaj +3 more sources
Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing? [PDF]
Antioxidants, 2018 Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. However, the analysis of neopterin alone neglects the cellular reactions that generate it in response to ...
Steven P. Gieseg +2 more
doaj +3 more sources
Pteridines, 2020 Introduction: Neopterin and 7,8-dihydroneopterin are used as biomarkers of oxidative stress and inflammation, but the effect of kidney function on these measurements has not been extensively explored.
Baxter-Parker Gregory +6 more
doaj +2 more sources
Effect of 7,8 -Dihydroneopterin, Biopterin and Isoxanthopterin on Cholesterol and Phospholipid Content and Phospholipid Biosynthesis in Vitro [PDF]
Pteridines, 1996 Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate (Krebs-Ringer-phosphate buffer, pH=7.4, containing 0.3% albumin, fatty acid mixture and glycerol). The addition of 7,8-dihydroneopterin and
Rudzite Vera +4 more
doaj +2 more sources
FolX from Pseudomonas aeruginosa is octameric in both crystal and solution [PDF]
FEBS Letters, Volume 586, Issue 8, Page 1160-1165, April 24, 2012., 2012 FolX and FolX bind by x ray scattering (View interaction)
Mads Gabrielsen +4 more
wiley +2 more sources
Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild. [PDF]
Am J PrimatolNeopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Behringer V, Deimel C.
europepmc +2 more sources
Effect of neopterin and 7,8‐dihydroneopterin on tumor necrosis factor‐α induced programmed cell death [PDF]
FEBS Letters, 1995 Tumor necrosis factor‐α and the formation of reactive oxygen intermediates are central mediators of apoptosis. Recent data indicated a role of neopterin and 7,8‐dihydroneopterin in oxygen radical mediated processes. We have therefore investigated the effect of neopterin‐derivatives on TNFα induced apoptosis of the monocyte‐like cell line U937.
Baier-Bitterlich, Gabriele +8 more
openaire +3 more sources
Impact‐induced muscle damage and urinary pterins in professional rugby: 7,8‐dihydroneopterin oxidation by myoglobin [PDF]
Scandinavian Journal of Medicine & Science in Sports, 2015 Muscle damage caused through impacts in rugby union is known to increase oxidative stress and inflammation. Pterins have been used clinically as markers of oxidative stress, inflammation, and neurotransmitter synthesis. This study investigates the release of myoglobin from muscle tissue due to force‐related impacts and how it is related to the ...
A, Lindsay +6 more
core +5 more sources
Integrated metabolome and transcriptome analysis reveals key genes and pathways associated with egg yolk percentage in chicken [PDF]
Poultry ScienceYolk percentage is a critical index in the egg product industry, reflecting both nutritional value and economic benefits. To elucidate the underlying mechanisms that contribute to variations in egg yolk percentage, we performed integrated transcriptome ...
Wen Li +5 more
doaj +2 more sources