Results 51 to 60 of about 5,716 (181)

Urinary Neopterin Concentrations in Healthy Individuals with Household Contact

Pteridines, 2003
Increased neopterin concentrations in serum and urine indicate activation of cell-mediated immunity. In this study, urinary neopterin concentrations of a family consisting of 1 child (aged 5 years), her parents, and her grandparents were determined over ...
Winkler Christiana, Wirleitner Barbara, Werner Ernst R., Fuchs Dietmar   +3 more
doaj   +1 more source

Clinical and Genetic Characteristics of Free Sialic Acid Storage Disorder

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Free sialic acid storage disorder (FSASD) is a lysosomal storage disorder that results from biallelic pathogenic variants in the SLC17A5 gene. This gene codes for sialin, a 12‐transmembrane domain protein that exports the charged sugar N‐acetylneuraminic acid (Neu5Ac; sialic acid) out of the lysosome.
Zoe Wolfenson, Gabriella Grois, Ruth F. Hailemeskel, Marla Sabaii, Laryssa A. Huryn, Wadih M. Zein, Tanya Lehky, Audrey Thurm, Lisa Joseph, Eva H. Baker, Gilbert Vezina, Keith Hyland, Laura Pollard, Ellen Macnamara, Andrea Gropman, May C. Malicdan, William A. Gahl, David R. Adams, Lynne Wolfe   +18 more
wiley   +1 more source

Salivary neopterin concentrations in patients with cancer of the oral cavity

Pteridines, 2016
Tumors of the oral cavity are relatively common malignancies with a poor prognosis. Use of both prognostic and predictive biomarkers in saliva represents one approach to improve the management of patients with these cancers.
Pink Richard, Melichar Bohuslav, Tomandl Josef, Blažková Lenka, Tvrdý Peter, Zapletalová Jana   +5 more
doaj   +1 more source

Clinical Value of Neopterin In Infectious Complications

Pteridines, 1999
Neopterin, a pteridine intermediate metabolite in the biopterine synthetic pathway, is synthesized and secreted by monocyte/macrophages upon stimulation, mainly by gamma-interferon by activated T cells.
Iwagaki Hiromi, Hizuta Akio, Kobashi Kenta, Isozaki Hiroshi, Takakura Norihisa, Tanaka Noriaki   +5 more
doaj   +1 more source

Functional Training Mitigates Reduced Circulating Indole‐3‐Lactate Levels in Persons With Relapsing–Remitting Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim Indoles are tryptophan (Trp)‐derived metabolites that are produced by the gut microbiota and may influence the gut‐microbiota‐brain axis in multiple sclerosis (MS). Indole‐3‐lactate (ILA) is reduced in persons with MS and improves MS clinical scores in animal models via its anti‐inflammatory remyelinating properties.
Tiffany Wences Chirino, Frederike Adammek, Sergen Belen, Matteo Winker, Sebastian Proschinger, Annette Rademacher, Marit L. Schlagheck, Alexander Schenk, Marie Kupjetz, David Walzik, Clemens Warnke, Marcel Reuter, Friederike Rosenberger, Tim Meyer, Adrian McCann, Per Magne Ueland, Niklas Joisten, Philipp Zimmer   +17 more
wiley   +1 more source

Urinary Neopterin in Patients with Ovarian Cancer

Pteridines, 2006
Urinary neopterin, an indicator of systemic immune activation, is increased in most patients with epithelial ovarian carcinoma (EOC) and is an independent prognostic indicator.
Melichar Bohuslav, Krcmová Lenka, Kalabova Hana, Svobodova Iveta, Dragounova Emanuela, Vesely Pavel, Hyspler Radomír, Solichova Dagmar, Urbanek Lubor   +8 more
doaj   +1 more source

Serum Neopterin Levels in Lung and Breast Cancer Patients Undergoing Radiotherapy And/Or Chemotherapy

The International Journal of Biological Markers, 1988
The elevated neopterin levels observed in numerous haemotological diseases and parenchymatous malignomas suggested neopter in might be useful as a tumor marker.
G. von Ingersleben, R. Souchon, R. Fitzner   +2 more
doaj   +1 more source

Transition From Juvenile Dermatomyositis to Spondyloarthritis: A Novel Overlapping Inflammatory Phenotype [PDF]

ACR Open Rheumatol
Objective Juvenile dermatomyositis (JDM) is a rare childhood inflammatory myopathy, whereas spondyloarthritis (SpA) is an inflammatory arthropathy characterized by enthesitis and peripheral or axial involvement. We describe a series of patients diagnosed with JDM in childhood who later fulfilled classification criteria for SpA, a sequential phenotype ...
Grooms A, Karageorgiou I, Mychaliska K, Birmingham J.   +3 more
europepmc   +2 more sources

The role of Neopterin in cardiovascular disease

Monaldi Archives for Chest Disease, 2016
Inflammation plays a key role in the initiation and progression of atherosclerosis but also in the pathophysiology of atheromatous plaque disruption and the development of acute coronary syndromes. Neopterin is a marker of inflammation and of immune system activation, it is synthesized by macrophages, that, once activated, release this substance ...
Pacileo, M., Plinio CIRILLO, Rosa, S., Ucci, G., Petrillo, G., D Amore, S. M., Sasso, L., Maietta, P., Spagnuolo, R., Chiariello, M.   +9 more
openaire   +5 more sources

Clinical importance of serum neopterin level in patients with pulmonary tuberculosis

International Journal of Mycobacteriology, 2014
Objective: Neopterin is a sensitive marker for cell-mediated immune response. Because of this, the neopterin levels of body fluids show cell-mediated immune response in different infectious diseases which involve T cells and macrophages.
Salih Cesur, Turan Aslan, Nevin Taci Hoca, Filiz Çimen, Gülnur Tarhan, Aydın Çifçi, İsmail Ceyhan, Tuğrul Şipit   +7 more
doaj   +1 more source