Results 11 to 20 of about 1,141,006 (274)
Imbalanced kynurenine pathway in schizophrenia [PDF]
International Journal of Tryptophan Research, 2014 Several studies suggest a role for kynurenic acid (KYNA) in the pathophysiology of schizophrenia. It has been proposed that increased brain KYNA levels in schizophrenia result from a pathological shift in the kynurenine pathway toward enhanced KYNA ...
Engberg, G, +9 more
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Kynurenine pathway metabolites and suicidality [PDF]
Neuropharmacology, 2017 Suicide is a major global problem, claiming more than 800,000 lives annually. The neurobiological changes that underlie suicidal ideation and behavior are not fully understood.
Bryleva, Elena Y., Brundin, Lena
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Kynurenine acid - metabolism and regulation of kynurenine pathway
Journal of Education, Health and Sport, 2017 Kynurenic acid (KYNA) was first isolated from the dog's urine in 1853 by german chemist Justus von Liebig. KYNA probably plays an important role in the pathogenesis of many neurodegenerative and psychiatric diseases. Its elevated concentration were found
Piotr Kozłowski, Magdalena Kozlowska
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Kynurenine Pathway in Psoriasis—a Promising Link?
Dermatology and Therapy, 2023 Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome.
A. Stepaniuk, A. Baran, I. Flisiak
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Kynurenine pathway in kidney diseases [PDF]
Pharmacological Reports, 2021 AbstractKidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders the prevalence of these diseases will increase over the coming decades. Despite available laboratory tests, accurate and rapid diagnosis of renal dysfunction has yet to be realized, and prognosis ...
Izabela Zakrocka, Wojciech Załuska
openaire +3 more sources
Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview
Mediators of Inflammation, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs.
Sagar Vyavahare +9 more
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Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review
Journal of Neuroinflammation, 2020 Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi +3 more
doaj +1 more source
Critical Care Medicine, 2012 The kynurenine pathway represents a major route for the catabolism of tryptophan (TRP). In the body, TRP is transported around the periphery either bound to albumin (90%) or in free form (10%), the two states existing in equilibrium (McMenamy 1965). However, only free form TRP can be transported across the blood-brain barrier (BBB) by the competitive ...
Yiquan Chen, Gilles Guillemi
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The kynurenine pathway in cognition, dementia, and aging [PDF]
, 2021 Background: Experimental studies implicate the kynurenine pathway in cognitive function, dementia, aging, and longevity. Comparatively, clinical studies are few and most lack comprehensive targeted metabolomic profiling of the kynurenine pathway ...
Solvang, Stein-Erik Hafstad
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Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]
, 2009 Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Barrett, M.P. +4 more
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