Results 11 to 20 of about 1,450,510 (208)

The Tryptophan–Kynurenine Pathway in Immunomodulation and Cancer Metastasis [PDF]

Cancer Medicine, 2023
Introduction The activation of the kynurenine pathway in cancer progression and metastasis through immunomodulatory pathways has drawn attention to the potential for kynurenine pathway inhibition.
June C Serem, Yvette Nkondo Hlophe, Priyesh Bipath   +2 more
exaly   +4 more sources

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors

Molecules, 2022
Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan.
Robert S. Phillips, J Phillip Bowen
exaly   +4 more sources

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition [PDF]

Frontiers in Molecular Biosciences, 2019
The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips, J Phillip Bowen, Tamera Hughes   +2 more
exaly   +4 more sources

Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview

Mediators of Inflammation, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs.
Sagar Vyavahare, Sandeep Kumar, Nicholas Cantu, Ravindra Kolhe, Wendy B. Bollag, Meghan E. McGee-Lawrence, William D. Hill, Mark W. Hamrick, Carlos M. Isales, Sadanand Fulzele   +9 more
doaj   +2 more sources

The kynurenine pathway in Alzheimer’s disease: a meta-analysis of central and peripheral levels [PDF]

Brazilian Journal of Psychiatry, 2023
Objective: Changes in the kynurenine pathway are recognized in psychiatric disorders, but their role in Alzheimer’s disease (AD) is less clear. We aimed to conduct a systematic review and meta-analysis to determine whether tryptophan and kynurenine ...
Brisa S. Fernandes, Mehmet Enes Inam, Nitesh Enduru, Joao Quevedo, Zhongming Zhao   +4 more
doaj   +2 more sources

Identification of Gut Microbiome Signatures Associated with the Kynurenine Pathway in Tryptophan Metabolism in Patients Undergoing Hemodialysis. [PDF]

Microorganisms
Patients with chronic kidney disease (CKD) and hemodialysis (HD) often experience gut microbiota dysbiosis, which may influence tryptophan metabolism through the kynurenine pathway.
Huang JK, Wu PH, Chen ZF, Liu PY, Chuang YS, Kuo MC, Chiu YW, Hsu PC, Kuo TH, Lin YT.   +9 more
europepmc   +2 more sources

The Role of Activation of the Tryptophan-Kynurenine Axis in the Pathogenesis of Acute Cerebrovascular Diseases: A Literature Review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Introduction: Acute cerebrovascular disorders are a major contributor to adult disability. The underlying processes that contribute to their development include inflammation, excitotoxicity, oxidative stress, and dysregulation of the tryptophan ...
Marina Grigolashvili, Alina Seryogina, Mira Beisembayeva, Shynar Muratbekova, Ivan Turkevich, Yelena Shayakhmetova   +5 more
doaj   +3 more sources

Linking major depressive disorder pathogenesis with kynurenine pathway - a literature review [PDF]

Journal of Education, Health and Sport, 2023
Introduction: Depressive disorders are a significant problem. They lead to suffering, loss of interest and may contribute to suicide attempts. Despite the large number of available medications, 10-35% of patients fail to achieve remission.
Dominik Szawica, Aleksandra Kuźniar, Kamila Fularska, Michał Oleszko, Edward Wąsiewicz   +4 more
doaj   +2 more sources

Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

European Pharmaceutical Journal, 2016
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Csanova A., Jezova D.
doaj   +2 more sources

Dissecting the enigma of scleroderma: possible involvement of the kynurenine pathway

Pteridines, 2017
The kynurenine pathway (KP) is the metabolic pathway via which L-tryptophan is converted to nicotinamide. It serves important immune-regulatory roles. This article will review the evidence for involvement of the KP in scleroderma and present a possible ...
Noakes Rowland
doaj   +2 more sources