Results 11 to 20 of about 2,991,386 (293)
Kynurenine acid - metabolism and regulation of kynurenine pathway
Journal of Education, Health and Sport, 2017 Kynurenic acid (KYNA) was first isolated from the dog's urine in 1853 by german chemist Justus von Liebig. KYNA probably plays an important role in the pathogenesis of many neurodegenerative and psychiatric diseases. Its elevated concentration were found
Piotr Kozłowski, Magdalena Kozlowska
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Kynurenine Pathway in Respiratory Diseases
International Journal of Tryptophan ResearchThe kynurenine pathway is the primary route for tryptophan catabolism and has received increasing attention as its association with inflammation and the immune system has become more apparent.
G. Pamart +4 more
semanticscholar +3 more sources
Kynurenine Pathway in Psoriasis—a Promising Link?
Dermatology and Therapy, 2023 Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome.
A. Stepaniuk, A. Baran, I. Flisiak
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Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders
Cells, 2021 Neurodegenerative disorders are chronic and life-threatening conditions negatively affecting the quality of patients’ lives. They often have a genetic background, but oxidative stress and mitochondrial damage seem to be at least partly responsible for ...
A. Mor +3 more
semanticscholar +3 more sources
The kynurenine pathway: towards metabolic equilibrium [PDF]
Neuropharmacology, 2016 No abstract ...
Clarke, Gerard +2 more
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Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects
International Journal of Tryptophan Research, 2017 Regulatory and functional aspects of the kynurenine (K) pathway (KP) of tryptophan (Trp) degradation are reviewed. The KP accounts for ~95% of dietary Trp degradation, of which 90% is attributed to the hepatic KP.
A. Badawy
semanticscholar +3 more sources
Kynurenine Pathway Metabolites as Biomarkers in Alzheimer's Disease [PDF]
Disease Markers, 2022 Alzheimer's disease (AD) is a progressive neurodegenerative disorder that deteriorates cognitive function. Patients with AD generally exhibit neuroinflammation, elevated beta-amyloid (Aβ), tau phosphorylation (p-tau), and other pathological changes in ...
Yuqing Liang +6 more
semanticscholar +3 more sources
Tryptophan-kynurenine pathway: a possible new mechanism for the prevention and treatment of reproductive system-related diseases [PDF]
PeerJTryptophan (Trp) is one of the essential amino acids, and its metabolic pathway is essential for the maintenance of normal human physiological activities.
Zhongkai Ou +4 more
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Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition [PDF]
Frontiers in Molecular Biosciences, 2019 The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips +4 more
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Frontiers in PsychiatryDepressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role.
Lucia Ilavská +7 more
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