Results 11 to 20 of about 26,876 (282)

Imbalanced kynurenine pathway in schizophrenia [PDF]

International Journal of Tryptophan Research, 2014
Several studies suggest a role for kynurenic acid (KYNA) in the pathophysiology of schizophrenia. It has been proposed that increased brain KYNA levels in schizophrenia result from a pathological shift in the kynurenine pathway toward enhanced KYNA ...
Engberg, G,, Kegel, ME, Lundberg, K, Schwieler, L,, Skogh, E, Dahl, M-L, Sellgren, C,, Schuppe-Koistinen, I, Samuelsson, M, Bhat, M   +9 more
core   +5 more sources

Kynurenine acid - metabolism and regulation of kynurenine pathway

Journal of Education, Health and Sport, 2017
Kynurenic acid (KYNA) was first isolated from the dog's urine in 1853 by german chemist Justus von Liebig. KYNA probably plays an important role in the pathogenesis of many neurodegenerative and psychiatric diseases. Its elevated concentration were found
Piotr Kozłowski, Magdalena Kozlowska
doaj   +4 more sources

Kynurenine Pathway in Psoriasis—a Promising Link?

Dermatology and Therapy, 2023
Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome.
A. Stepaniuk, A. Baran, I. Flisiak
doaj   +4 more sources

Kynurenine pathway metabolites and suicidality

Neuropharmacology, 2017
Suicide is a major global problem, claiming more than 800,000 lives annually. The neurobiological changes that underlie suicidal ideation and behavior are not fully understood.
Bryleva, Elena Y., Brundin, Lena
core   +3 more sources

Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview

Mediators of Inflammation, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs.
Sagar Vyavahare, Sandeep Kumar, Nicholas Cantu, Ravindra Kolhe, Wendy B. Bollag, Meghan E. McGee-Lawrence, William D. Hill, Mark W. Hamrick, Carlos M. Isales, Sadanand Fulzele   +9 more
doaj   +2 more sources

The Role of Activation of the Tryptophan-Kynurenine Axis in the Pathogenesis of Acute Cerebrovascular Diseases: A Literature Review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Introduction: Acute cerebrovascular disorders are a major contributor to adult disability. The underlying processes that contribute to their development include inflammation, excitotoxicity, oxidative stress, and dysregulation of the tryptophan ...
Marina Grigolashvili, Alina Seryogina, Mira Beisembayeva, Shynar Muratbekova, Ivan Turkevich, Yelena Shayakhmetova   +5 more
doaj   +2 more sources

Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain

Pharmaceuticals, 2023
Chronic pain is a pressing medical and socioeconomic issue worldwide. It is debilitating for individual patients and places a major burden on society in the forms of direct medical costs and lost work productivity.
Andrew Auyeung, Hank C. Wang, Kannan Aravagiri, Nebojsa Nick Knezevic   +3 more
doaj   +2 more sources

The kynurenine pathway is involved in bacterial meningitis. [PDF]

Journal of Neuroinflammation, 2014
BackgroundBacterial meningitis (BM) is characterized by an intense host inflammatory reaction, which contributes to the development of brain damage and neuronal sequelae.
Coutinho, Leonam G, Grandgirard, Denis, Bellac, Caroline L, Christen, Stephan, Fontes, Fabrícia, de Souza, Fladjule, Leib, Stephen, Agnez-Lima, Lucymara F   +7 more
core   +7 more sources

Kynurenine pathway in kidney diseases [PDF]

Pharmacological Reports, 2021
AbstractKidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders the prevalence of these diseases will increase over the coming decades. Despite available laboratory tests, accurate and rapid diagnosis of renal dysfunction has yet to be realized, and prognosis ...
Izabela Zakrocka, Wojciech Załuska
openaire   +3 more sources

Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease

Frontiers in Immunology, 2022
Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc.
Renáta Gáspár, Renáta Gáspár, Dóra Halmi, Dóra Halmi, Virág Demján, Virág Demján, Róbert Berkecz, Márton Pipicz, Márton Pipicz, Tamás Csont, Tamás Csont   +10 more
doaj   +1 more source