Results 41 to 50 of about 1,141,006 (274)
Role of kynurenine pathway in allergy
, 2016 [[abstract]]Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation.
Kawasaki, H;Huang, SK
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Study towards the quantitative definition of the kynurenine pathway [PDF]
, 2017 The kynurenine pathway is the prime pathway for the metabolism of the essential amino acid, tryptophan (TRP), and also the de novo pathway for nicotinamide adenine dinucleotide (NAD+) production. The kynurenine pathway is important in the pathogenesis
Murray, Toby Benjamin James
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Kynurenine pathway and human systems
Experimental Gerontology, 2020 The essential amino acid L-tryptophan (Trp) appears to play an important role in aging by acting as a general regulator of protein homeostasis. The major route of Trp degradation, the kynurenine pathway (KP), produces a range of biologically active metabolites that can impact or be impacted by a variety of body systems, including the endocrine ...
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Kynurenine pathway metabolites in migraine [PDF]
The Journal of Headache and Pain, 2015 Kynurenine pathway (KP), the quantitatively main branch of tryptophan metabolism, has long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to activate glutamate receptors, thus potentially influencing a large group of functions in the central ...
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Immunohistochemical Studies of the Kynurenine Pathway in Morphea [PDF]
International Journal of Tryptophan Research, 2013 Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved ...
Noakes, Rowland, Mellick, Nick
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Janus Reactivity of a Mononuclear Non‐Heme Iron(III)‐Peroxo Complex Toward Indole Oxidation
Angewandte Chemie, EarlyView.The iron(III)‐peroxo complex [FeIII(O2)(12‐TMC)]+ exhibits bifurcating pathways in indole oxidation. N─H indoles undergo N─H H‐atom abstraction, supported by a KIE of 5.2 for N─H/N–D 2,3‐dimethylindoles, whereas N‐methylindoles react via electrophilic addition of the iron‐peroxo group to the C2–C3 double bond of the indole ring, forming iron ...
Wenjuan Zhu +4 more
wiley +2 more sources
European Pharmaceutical Journal, 2016 The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Csanova A., Jezova D.
doaj +1 more source
Frontiers in Immunology, 2021 ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses.
Katrien Skorobogatov +13 more
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The involvement of Kynurenine pathway in multiple sclerosis mice model [PDF]
, 2012 Multiple sclerosis (MS) is a demyelinating disease of central nervous system caused by unknown multi-faceted disease inducing factors. Experimental autoimmune encephalomyelitis (EAE), an animal model for MS, manifests various forms that parallel several ...
Sundaram, Gayathri
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The kynurenine pathway is involved in bacterial meningitis [PDF]
Journal of Neuroinflammation, 2014 Bacterial meningitis (BM) is characterized by an intense host inflammatory reaction, which contributes to the development of brain damage and neuronal sequelae. Activation of the kynurenine (KYN) pathway (KP) has been reported in various neurological diseases as a consequence of inflammation.
Coutinho Leonam G. +7 more
openaire +5 more sources