Results 41 to 50 of about 23,868 (155)

Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD

Pharmaceuticals, 2023
Objectives: Despite distinct clinical profiles, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients share a remarkable portion of pathological features, with a substantial percentage of patients displaying a mixed disease ...
Annelies Heylen, Yannick Vermeiren, Ido P. Kema, Martijn van Faassen, Claude van der Ley, Debby Van Dam, Peter P. De Deyn   +6 more
doaj   +1 more source

The kynurenine pathway: a finger in every pie [PDF]

Molecular Psychiatry, 2019
The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially increased during an immune response, the KP is a key regulator of the immune system.
openaire   +2 more sources

Inhibitors of the Kynurenine Pathway [PDF]

, 2017
A central role in the immune escape of tumors has been attributed to the kynurenine pathway of tryptophan metabolism, leading to the depletion of tryptophan and the production of different bioactive metabolites. The first and rate-limiting step in this pathway is catalyzed by the phylogenetically unrelated enzymes indoleamine 2,3-dioxygenase 1 (IDO1 ...
Ute F. Röhrig, Vincent Zoete, Olivier Michielin   +2 more
openaire   +1 more source

Identification of overlooked tryptophan catabolism pathways in bacteria: a focus on rhizobacteria

Heliyon
Tryptophan (Trp) is primarily catabolized via the kynurenine or indolic pathways in bacteria, resulting in the production of biologically active compounds that are crucial for bacteria-host interactions.
Adrian Lautrey, Laurent Legendre, Florence Wisniewski-Dyé, Claire Prigent-Combaret   +3 more
doaj   +1 more source

The kynurenine pathway in HIV, frailty and inflammaging

Frontiers in Immunology, 2023
Kynurenine (Kyn) is a circulating tryptophan (Trp) catabolite generated by enzymes including IDO1 that are induced by inflammatory cytokines such as interferon-gamma. Kyn levels in circulation increase with age and Kyn is implicated in several age-related disorders including neurodegeneration, osteoporosis, and sarcopenia.
Shabiha Sultana, Anthony Elengickal, Husam Bensreti, Eric Belin de Chantemèle, Meghan E. McGee-Lawrence, Mark W. Hamrick   +5 more
openaire   +3 more sources

The kynurenine pathway is involved in bacterial meningitis [PDF]

Journal of Neuroinflammation, 2014
Bacterial meningitis (BM) is characterized by an intense host inflammatory reaction, which contributes to the development of brain damage and neuronal sequelae. Activation of the kynurenine (KYN) pathway (KP) has been reported in various neurological diseases as a consequence of inflammation.
Coutinho Leonam G., Christen Stephan, Bellac Caroline L., Fontes Fabrcia Lima, Soares de Souza Fladjule Rejane, Grandgirard Denis, Leib Stephen L., Agnez-Lima Lucymara F.   +7 more
openaire   +5 more sources

Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions

Molecular Pain
Chronic pain is a debilitating symptom with a significant negative impact on the quality of life and socioeconomic status, particularly among adults and the elderly.
Ebrahim Hazrati, Seyed Parsa Eftekhar, Reza Mosaed, Saeed Shiralizadeh Dini, Mehrshad Namazi   +4 more
doaj   +1 more source

Physicochemical Characterization of Kynurenine Pathway Metabolites. [PDF]

Antioxidants (Basel)
The kynurenine pathway is a significant metabolic route involved in the catabolism of tryptophan, producing various bioactive metabolites with crucial roles as antioxidants in immune regulation and neurobiology. This study investigates the acid-base properties of picolinic acid, kynurenic acid, kynurenine, and 3-hydroxykynurenine, utilizing ...
Buzásy L, Mazák K, Balogh B, Simon B, Vincze A, Balogh GT, Pálla T, Mirzahosseini A.   +7 more
europepmc   +4 more sources

Kynurenine Pathway Metabolites in Alzheimer’s Disease

Journal of Alzheimer’s Disease, 2017
Background: Metabolites of tryptophan, produced via the kynurenine pathway (kynurenines), have been linked to Alzheimer’s disease (AD) in small cohorts with conflicting results. Objective: To compare differences in plasma kynurenine ...
Giil, L, Midttun, Ø, Refsum, H, Ulvik, A, Advani, R, Smith, A, Ueland, P   +6 more
openaire   +3 more sources

The Involvement of Kynurenine Pathway in Neurodegenerative Diseases

Current Neuropharmacology, 2023
Background: A growing body of evidence has shown the involvement of the kynurenine pathway (KP), the primary route of tryptophan (TRP) catabolism, in the pathophysiology of neuropsychiatric disorders. Objective: The study aims to provide a comprehensive and critical overview of the clinical evidence on the KP involvement in the pathophysiology of ...
Martins, Lais B, Silveira, Ana L M, Teixeira, Antonio L   +2 more
openaire   +2 more sources