Results 41 to 50 of about 1,450,510 (208)

Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD

Pharmaceuticals, 2023
Objectives: Despite distinct clinical profiles, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients share a remarkable portion of pathological features, with a substantial percentage of patients displaying a mixed disease ...
Annelies Heylen, Yannick Vermeiren, Ido P. Kema, Martijn van Faassen, Claude van der Ley, Debby Van Dam, Peter P. De Deyn   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats

Neural Plasticity, 2016
Tryptophan is an essential dietary amino acid that is necessary for protein synthesis, but also serves as the precursor for serotonin. However, in addition to these biological functions, tryptophan also serves as a precursor for the kynurenine pathway ...
Haley A. Vecchiarelli, Chaitanya P. Gandhi, Matthew N. Hill   +2 more
doaj   +1 more source

Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives

Sensors, 2021
In recent years, tryptophan metabolism via the kynurenine pathway has become one of the most active research areas thanks to its involvement in a variety of physiological processes, especially in conditions associated with immune dysfunction, central ...
Ilona Sadok, Magdalena Staniszewska
doaj   +1 more source

The Tryptophan-Kynurenine Pathway, Systemic Inflammation, and Long-Term Outcome after Kidney Transplantation [PDF]

, 2017
BACKGROUND: Tryptophan is metabolized along the kynurenine pathway, initially to kynurenine, and subsequently to cytotoxic 3-hydroxykynurenine. There is increasing interest in this pathway, because of its pro-inflammatory nature, and drugs interfering in
Bakker, Stephan Jl; id_orcid, Martijn van Faassen, Berger, Stefan P, Stefan P. Berger, de Vries, Laura V, Casper F.M. Franssen, Isidor Minović, Gerjan Navis, van Faassen, Martijn, Navis, Gerjan, Laura V. de Vries, Minovic, Isidor, Kema, Ido P, Kema, Ido P; id_orcid, Stephan J. L. Bakker, van Faassen, Martijn; id_orcid, Jan-Stephan F. Sanders, Ido P. Kema, Sanders, Jan-Stephan F., Franssen, Casper Fm; id_orcid, Sanders, Jan-Stephan F.; id_orcid, Bakker, Stephan Jl, Franssen, Casper Fm   +22 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes [PDF]

, 2005
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA
Newcombe, J, Kalina, P, Kepplinger, B, Baran, H, Ferraz-Leite, H, Kainz, A   +5 more
core  

Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma

Frontiers in Oncology, 2020
Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabolites
Soudabeh Rad Pour, Hiromasa Morikawa, Narsis A. Kiani, Narsis A. Kiani, David Gomez-Cabrero, David Gomez-Cabrero, Alistair Hayes, Xiaozhong Zheng, Maria Pernemalm, Janne Lehtiö, Damian J. Mole, Johan Hansson, Johan Hansson, Hanna Eriksson, Hanna Eriksson, Jesper Tegnér, Jesper Tegnér, Jesper Tegnér   +17 more
doaj   +1 more source

Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders

Frontiers in Immunology, 2021
ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses.
Katrien Skorobogatov, Katrien Skorobogatov, Livia De Picker, Livia De Picker, Robert Verkerk, Violette Coppens, Violette Coppens, Marion Leboyer, Marion Leboyer, Marion Leboyer, Marion Leboyer, Norbert Müller, Manuel Morrens, Manuel Morrens   +13 more
doaj   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source