Results 51 to 60 of about 2,991,386 (293)

Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial

Journal of Neuroinflammation, 2021
Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS
Vincent Millischer, Matthias Heinzl, Anthi Faka, Michael Resl, Ada Trepci, Carmen Klammer, Margot Egger, Benjamin Dieplinger, Martin Clodi, Lilly Schwieler   +9 more
doaj   +1 more source

Obesity and cancer: existing and new hypotheses for a causal connection [PDF]

, 2018
Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly, but recent evidence suggests a major role for chronic inflammation in cancer
Darlington, L. Gail, McPherson, Megan, Stone, Trevor W.   +2 more
core   +2 more sources

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. [PDF]

, 2016
Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing.
Abu Aboud, Omran, Anderson, Katie, Berryhill, Grace, Chen, Ching-Hsien, Graef, Ashley, Hovey, Russell C, Kim, Jeffrey, Modiano, Jaime F, Sarver, Aaron L, Stewart, Benjamin, Trott, Josephine F, Uzal, Francisco, Weiss, Robert H, Wettersten, Hiromi   +13 more
core   +2 more sources

Peripheral and central kynurenine pathway abnormalities in major depression.

Brain, behavior, and immunity, 2022
Considerable data relate major depressive disorder (MDD) with aberrant immune system functioning. Pro-inflammatory cytokines facilitate metabolism of tryptophan along the kynurenine pathway (KP) putatively resulting in reduced neuroprotective and ...
Elisabeth R Paul, L. Schwieler, S. Erhardt, Sandra Boda, Ada Trepci, Robin Kämpe, A. Asratian, Lovisa Holm, A. Yngve, R. Dantzer, M. Heilig, J. Paul Hamilton, M. Samuelsson   +12 more
semanticscholar   +1 more source

Role of Indoleamine 2,3-dioxygenase 1 (IDO1) and Kynurenine pathway in the regulation of the aging process.

Ageing Research Reviews, 2022
Indoleamine 2,3-dioxygenase 1 (IDO1) is activated in chronic inflammatory states, e.g., in the aging process and age-related diseases. IDO1 enzyme catabolizes L-tryptophan (L-Trp) into kynurenine (KYN) thus stimulating the KYN pathway. The depletion of L-
A. Salminen
semanticscholar   +1 more source

Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children [PDF]

, 2015
Enteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases.
Guerrant, RL, Havt, A, Leite, Á, Lima, AAM, Lima, NL, Mayneris-Perxachs, J, Moore, SR, Moura, AF, Pinkerton, R, Soares, AM, Swann, JR   +10 more
core   +1 more source

Involvement of Kynurenine Pathway in Hepatocellular Carcinoma [PDF]

Cancers, 2021
As the second and third leading cancer-related death in men and the world, respectively, primary liver cancer remains a major concern to human health. Despite advances in diagnostic technology, patients with primary liver cancer are often diagnosed at an advanced stage.
Shivani Krishnamurthy, David Gilot, Seong Beom Ahn, Vincent Lam, Joo-Shik Shin, Gilles Jackie Guillemin, Benjamin Heng   +6 more
openaire   +3 more sources

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways [PDF]

, 2012
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines.
A Bosutti, A Jellema, A Laugeray, A Peters, A Rossi-George, A Schaffner, AA Wadee, AH Swiergiel, AJ Grossberg, AL Hassett, AL Lacerda, AM Myint, AN van den Pol, AS El-Radhi, AS Wrynn, AY Lai, B Leonard, B Owe-Larsson, BE Leonard, BE Leonard, BG Charlton, BL Hart, Brian Leonard, C Celik, C Nathan, C Song, C Song, C Song, C Song, C Song, CA Stockmeier, Cai Song, CL Raison, D Brustolim, D Wang, DK Kinney, EA Stone, ES Wohleb, F Frenois, F Kapczinski, F Moroni, G Anderson, G Werner-Felmayer, George Anderson, GM MacQueen, GR Steinberg, H Anisman, H Anisman, H Nakanishi, HC Liu, HP Kopp, I Kirsch, IK Lampe, IR Bell, J Hannestad, J Steiner, JC O'Connor, JE Bower, JE Holmes, JL Rausch, JM Twenge, KJ Jung, KJ Tracey, KS Kendler, L MacDonald, L Qin, L Toker, LE Goehler, LE Goehler, Lisa Goehler, LJ Williams, LM Harden, LV Kessing, LV Kessing, M Adib-Conquy, M Berk, M Berk, M Berk, M Berk, M Catena-Dell'Osso, M Kauer-Sant'Anna, M Koenigs, M Kubera, M Kubera, M Lyte, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, MB Hennessy, MB Howren, MC McKinnon, MC Wichers, MC Wichers, MC Wichers, MD Burton, ME Sublette, Michael Berk, Michael Maes, MJ Hoes, MJ Kluger, MJ Kluger, MJ Sharman, MP Szuba, MT Berlim, N Castanon, N Castex, NA Harrison, O Caliyurt, O Takikawa, P Gorwood, P Taepavarapruk, P Videbech, Piotr Gałecki, R Dantzer, R Medzhitov, R Roubenoff, R Yirmiya, RC Bone, RH Straub, RJ Boland, RK Jewkes, RK Kumar, RM Post, RPA Gaykema, RPA Gaykema, RPA Gaykema, RW Johnson, S Bonaccorso, S Bonaccorso, S Cunningham-Rundles, S Lacosta, S Rantala, S-M Park, SC Strijdom, SD Burdette, SE Møller, SF Maier, SM Antelman, SM Jancsár, SM O'Brien, SM Sylvén, T Hochstrasser, T Liukkonen, T Sato, T Tuma, TA Lennie, TC Olde Hartman, TM Piser, V Gabbay, WC Drevets, WS Yang, Y Dowlati, Y Huang, Y Jiang, Y Kawasaki, Y Liu, Z Pavlovićc, Z Xia   +189 more
core   +2 more sources

The kynurenine pathway in HIV, frailty and inflammaging

Frontiers in Immunology, 2023
Kynurenine (Kyn) is a circulating tryptophan (Trp) catabolite generated by enzymes including IDO1 that are induced by inflammatory cytokines such as interferon-gamma.
Shabiha Sultana, Anthony Elengickal, Husam Bensreti, Eric Belin de Chantemèle, M. McGee-Lawrence, M. Hamrick   +5 more
semanticscholar   +1 more source

The kynurenine pathway and neurodegenerative disease [PDF]

Seminars in Cell & Developmental Biology, 2015
Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan is an essential amino acid required for protein synthesis, and in higher eukaryotes is also converted into the key neurotransmitters serotonin and tryptamine. However, in mammals
Maddison, Daniel C., Giorgini, Flaviano
openaire   +3 more sources