Results 51 to 60 of about 1,450,510 (208)

Measurement of kynurenine pathway metabolites by tandem mass spectrometry

Journal of Mass Spectrometry and Advances in the Clinical Lab, 2023
Objectives: Recent studies have shown that derangements in kynurenine pathway metabolite levels are associated with various pathologies such as neurodegenerative diseases, schizophrenia, depression, bipolar disorder, rheumatoid arthritis, and cancer ...
Sedat Abusoglu, Duygu Eryavuz Onmaz, Gulsum Abusoglu, Fatma Humeyra Yerlikaya, Ali Unlu   +4 more
doaj   +1 more source

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source

The Kynurenine pathway in pancreatic carcinoma

, 2017
IntroductionPancreatic carcinoma (PC) belongs to the most aggressive tumours worldwide, with a five year survival of 7%. Mostly, diagnosis is made in late stages, as by now no early detection method is available.
A. Baranyi, C. Blesl, A. Meinitzer, A. Holl, A. Painold, A. Tmava, H.P. Kapfhammer, S. Mörkl, V. Stadlbauer-Köllner   +8 more
core   +1 more source

Kynurenine Pathway Activation and Deviation to Anthranilic and Kynurenic Acid in Fibrosing Chronic Graft-Versus-Host Disease, Orsatti et al.

, 2021
R code for data analysis, measurements of kynurenine metabolites and cytokines related to "Orsatti, Stiehl, Dischinger, ..., Luft: Kynurenine Pathway Activation and Deviation to Anthranilic and Kynurenic Acid in Fibrosing Chronic Graft-Versus-Host ...
Stiehl, T (via Mendeley Data), Stiehl, Thomas   +1 more
core   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain.

PLoS ONE, 2013
To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the ...
Wei Wu, Joseph A Nicolazzo, Li Wen, Roger Chung, Roger Stankovic, Shisan S Bao, Chai K Lim, Bruce J Brew, Karen M Cullen, Gilles J Guillemin   +9 more
doaj   +1 more source

The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis

Microorganisms, 2021
In children, tick-borne encephalitis and neuroborreliosis are common infections affecting the central nervous system. As inflammatory pathways including cytokine expression are activated in these children and appear to be of importance for outcome, we ...
Ronny Wickström, Åsa Fowler, Michel Goiny, Vincent Millischer, Sofia Ygberg, Lilly Schwieler   +5 more
doaj   +1 more source

Highly‐Time‐Resolved Measurements of Tryptophan's Distribution and Homeostatic Regulation in Live, Intact Animals

Advanced Science, EarlyView.
Using a novel, aptamer‐based biosensor, here we have performed 20‐s‐resolved, in situ measurements of plasma‐free tryptophan in the jugular veins of live rats (blue). This unprecedented time‐resolution provides insights into the regulation of tryptophan metabolism in live, intact animals.
Yuyang Wu, Chelsea N. Brown, Zeki Duman, Rose Mery Bakestani, Carl M. Kirkpatrick, Joao Hespanha, Tod Kippin, Kevin W. Plaxco   +7 more
wiley   +1 more source

Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions

Molecular Pain
Chronic pain is a debilitating symptom with a significant negative impact on the quality of life and socioeconomic status, particularly among adults and the elderly.
Ebrahim Hazrati, Seyed Parsa Eftekhar, Reza Mosaed, Saeed Shiralizadeh Dini, Mehrshad Namazi   +4 more
doaj   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source