Results 61 to 70 of about 1,450,510 (208)

Bioengineered Stroma‐Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity

Advanced Science, EarlyView.
Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang, Jing Luo, Mengdi Zhang, Jingying Zhuang, Yating Zheng, Yang Zhang, Zhihong Huang, Xinhua Lin, Shuzhen Xu, Hong Yao, Gang Liu, Bing Chen   +11 more
wiley   +1 more source

Identification of overlooked tryptophan catabolism pathways in bacteria: a focus on rhizobacteria

Heliyon
Tryptophan (Trp) is primarily catabolized via the kynurenine or indolic pathways in bacteria, resulting in the production of biologically active compounds that are crucial for bacteria-host interactions.
Adrian Lautrey, Laurent Legendre, Florence Wisniewski-Dyé, Claire Prigent-Combaret   +3 more
doaj   +1 more source

Clinical predictors of kynurenine pathway aberrations in schizophrenia and bipolar disorder

European Psychiatry, 2022
Introduction Schizophrenia and bipolar disorder are severe mental illnesses that are known to have a considerable overlap in underlying pathophysiological mechanisms.
K. Skorobogatov, M. Leboyer, M. Foiselle, M. Morrens, L. De Picker   +4 more
doaj   +1 more source

Enzyme activities along the kynurenine pathway in mice

, 2003
Tryptophan metabolism was studied in adult male Swiss mice by determining enzyme activities along the kynurenine pathway. The following enzymes were assayed: liver tryptophan 2,3-dioxygenase, small intestine indole 2,3-dioxygenase, liver and kidney ...
ALLEGRI, GRAZIELLA, COSTA, CARLO VIRGILIO LUIGI, RAGAZZI, EUGENIO, BERTAZZO, ANTONELLA, Allegri Graziella, Eugenio Ragazzi, Carlo V. L. Costa, Bertazzo Antonella   +7 more
core   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Bacillus Licheniformis‐Induced Cognitive Decline in Mice Linking Gut Microbiota Dysbiosis, Metabolic Perturbations, and Hippocampal Neuroinflammation

Advanced Science, EarlyView.
Chronic oral administration of specific probiotic strains triggers gut microbiota dysbiosis and systemic metabolic perturbations in mice. Multi‐omics profiling reveals subsequent hippocampal glial remodeling and neuroinflammation, which are linked to cognitive impairment.
Yibin Lin, Afeng Wang, Hongchang Zhou, Yuliang Sun, Yingying Guo, Keyu Chen, Junhong Sun, Tinliang Lin, Zhaochen Huang, Xinhua Qiang, Jie He, Jianlin Lou, Yunliang Yao, Shengwen Shao, Yongliang Pan, Xiang Wang   +15 more
wiley   +1 more source

Tryptophan-kynurenine pathway: a possible new mechanism for the prevention and treatment of reproductive system-related diseases [PDF]

PeerJ
Tryptophan (Trp) is one of the essential amino acids, and its metabolic pathway is essential for the maintenance of normal human physiological activities.
Zhongkai Ou, Aixia Xu, Hua Su, Yiting Liu, Jia Li   +4 more
doaj   +2 more sources

Targeting Kynurenine Synthesis Attenuated Cigarette Smoke‐Induced COPD‐Like Lung Injury Driven by TALDO1‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Cigarette smoke induces airway epithelial TALDO1 upregulation and L‐kynurenine accumulation, driving mitochondrial injury with elevated mtROS, reduced Δψm, ATP, and OCR. This links to lung inflammation, alveolar destruction, and lung function damage, all attenuated by Epacadostat or Taldo1 reduction.
Wenjing Wang, Mindan Wu, Yuanlan Yang, Zemin Chen, Jiawei Yan, Xuan Jin, Yachao Cui, Feng Zhang, Haiqing Li, Wensheng Chen, Yumin Zhou, Leqing Zhu, Wei Tu, Pixin Ran   +13 more
wiley   +1 more source

Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype

, 2005
The gene coding for arylformamidase (Afmid, also known as kynurenine formamidase) was inactivated in mice through the removal of a shared bidirectional promoter region regulating expression of the Afmid and thymidine kinase (Tk) genes. Afmid/Tk-deficient
Pabarcus, Michael K., Dobrovolsky, Vasily N., Bowyer, John F., Heflich, Robert H., Williams, Lee D., Doerge, Daniel R., Bergquist, Jonas,, Casida, John E., Arvidsson, Björn,   +8 more
core   +6 more sources

Brain and plasma levels of tryptophan and kynurenine pathway metabolites.

, 2015
Values (ng/ml) represent mean ± SEM.Brain and plasma levels of tryptophan and kynurenine pathway metabolites.
Kamila Syslova (684667), Petr Kacer (684668), Jiri Horacek (684673), Hana Tejkalova (684666), Jana Vondrousova (684669), Michaela Fujakova (684671), Filip Tyls (684670), Anna Kubesova (684665), Tomas Palenicek (684672)   +8 more
core   +1 more source