Results 81 to 90 of about 1,450,510 (208)

Enzyme activities involved in tryptophan metabolism along the kynurenine pathway in rabbits

, 2001
The following enzyme activities of the tryptophan-nicotinic acid pathway were studied in male New Zealand rabbits: liver tryptophan 2,3-dioxygenase, intestine indole 2,3-dioxygenase, liver and kidney kynurenine 3-monooxygenase, kynureninase, kynurenine ...
ALLEGRI, GRAZIELLA, COSTA, CARLO VIRGILIO LUIGI, RAGAZZI, EUGENIO, BIASIOLO M, BERTAZZO, ANTONELLA, Eugenio Ragazzi, Monica Biasiolo, Carlo V.L Costa, Graziella Allegri, Antonella Bertazzo   +9 more
core   +1 more source

The involvement of Kynurenine pathway in multiple sclerosis mice model [PDF]

, 2012
Multiple sclerosis (MS) is a demyelinating disease of central nervous system caused by unknown multi-faceted disease inducing factors. Experimental autoimmune encephalomyelitis (EAE), an animal model for MS, manifests various forms that parallel several ...
Sundaram, Gayathri
core   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity

European Pharmaceutical Journal, 2016
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Slovák L., Poništ S., Kuncírová V., Mihalová D., Fedorova T., Bauerová K.   +5 more
doaj   +1 more source

The kynurenine pathway in patients with rheumatoid arthritis during tumor necrosis factor α inhibitors treatment

Objectives The importance of the kynurenine pathway in normal immune system function has led to an appreciation of its possible contribution to autoimmune disorders such as rheumatoid arthritis (RA).
Dorota Sikorska, Rafał Rutkowski, Joanna Witoszyńska-Sobkowiak, Iwona Żychowska, Karolina Niklas, Włodzimierz Samborski   +5 more
core   +1 more source

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source

Imbalanced kynurenine pathway in schizophrenia

, 2014
Several studies suggest a role for kynurenic acid (KYNA) in the pathophysiology of schizophrenia. It has been proposed that increased brain KYNA levels in schizophrenia result from a pathological shift in the kynurenine pathway toward enhanced KYNA ...
Engberg, G,, Kegel, ME, Lundberg, K, Schwieler, L,, Skogh, E, Dahl, M-L, Sellgren, C,, Schuppe-Koistinen, I, Samuelsson, M, Bhat, M   +9 more
core   +2 more sources

Improving the Sensitivity in Chiral Analysis by Capillary Electrophoresis

ELECTROPHORESIS, EarlyView.
Most recent advances for the enhancement of sensitivity in capillary electrophoresis, including off‐line and in‐capillary preconcentration techniques and their combinations, and the use of alternative detection systems to UV–Vis spectrophotometric absorption.
María Castro‐Puyana, Sandra Salido‐Fortuna, María Luisa Marina   +2 more
wiley   +1 more source

The Kynurenine Pathway in Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A Large Meta-Analysis

, 2021
The Kynurenine Pathway in Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A Large Meta ...
Marsal Sanches (13303764), Jair Soares (3495134), Joao Quevedo (2608285), Brisa Fernandes (3495122), Amelia McGuinness (13303704), Alexandre Diaz (15835076), Wolf Marx (13100121)   +6 more
core