Results 81 to 90 of about 2,991,386 (293)

The role of the kynurenine pathway in cardiovascular disease

Frontiers in Cardiovascular Medicine
The kynurenine pathway (KP) serves as the primary route for tryptophan metabolism in most mammalian organisms, with its downstream metabolites actively involved in various physiological and pathological processes.
Yuehang Yang, Xinghui Liu, Xinyi Liu, Chiyang Xie, Jiawei Shi   +4 more
semanticscholar   +1 more source

Translating Metabolic Reprogramming into New Targets for Kidney Cancer. [PDF]

, 2017
In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered.
Abu Aboud, Omran, Weiss, Robert H
core   +1 more source

Kynurenine Pathway Metabolites in Alzheimer’s Disease

Journal of Alzheimer’s Disease, 2017
Background: Metabolites of tryptophan, produced via the kynurenine pathway (kynurenines), have been linked to Alzheimer’s disease (AD) in small cohorts with conflicting results. Objective: To compare differences in plasma kynurenine levels between AD and controls and identify potential associations with cognition.
Giil, L, Midttun, Ø, Refsum, H, Ulvik, A, Advani, R, Smith, A, Ueland, P   +6 more
openaire   +3 more sources

Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats

Neural Plasticity, 2016
Tryptophan is an essential dietary amino acid that is necessary for protein synthesis, but also serves as the precursor for serotonin. However, in addition to these biological functions, tryptophan also serves as a precursor for the kynurenine pathway ...
Haley A. Vecchiarelli, Chaitanya P. Gandhi, Matthew N. Hill   +2 more
doaj   +1 more source

The Footprint of Kynurenine Pathway in Cardiovascular Diseases

International Journal of Tryptophan Research, 2022
Kynurenine pathway is the main route of tryptophan metabolism and produces several metabolites with various biologic properties. It has been uncovered that several cardiovascular diseases are associated with the overactivation of kynurenine pathway and ...
Moein Ala, S. P. Eftekhar
semanticscholar   +1 more source

Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

European Pharmaceutical Journal, 2016
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Csanova A., Jezova D.
doaj   +1 more source

Plant chemical genetics : from phenotype-based screens to synthetic biology [PDF]

, 2017
The treatment of a biological system with small molecules to specifically perturb cellular functions is commonly referred to as chemical biology. Small molecules are used commercially as drugs, herbicides, and fungicides in different systems, but in ...
Dejonghe, Wim, Russinova, Eugenia
core   +3 more sources

The Kynurenine Pathway in Gut Permeability and Inflammation

Inflammation
The gut-brain axis (GBA) is a crucial communication network linking the gastrointestinal (GI) tract and the central nervous system (CNS). The gut microbiota significantly influences metabolic, immune, and neural functions by generating a diverse array of
R.P. Kearns
semanticscholar   +1 more source

Fluorescent Nanosensor for Indole‐3‐Propionic Acid Detection in Gut Health Monitoring

Advanced Healthcare Materials, EarlyView.
This work introduces a fluorescent nanosensor system with two optical modalities for detection of indole‐3‐propionic acid (IPA) gut metabolite: (1) blue‐emitting cationic conjugated polyelectrolyte (CP3) and (2) near‐infrared (NIR)‐emitting CP3‐wrapped single‐walled carbon nanotube (SWNT).
Mervin Chun‐Yi Ang, Jonathan Wei Jie Lee, Sayyid Mohaideen, Gabriel Sánchez‐Velázquez, Song Wang, Yangyang Han, Liu Lin, Germaine Yong, Raju Cheerlavancha, Duc Thinh Khong, Jianhong Ching, Sharon Hong Yu Han, Jun Yu Yeo, Lian Xu, Gajendra Pratap Singh, Michael S. Strano   +15 more
wiley   +1 more source

Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity

European Pharmaceutical Journal, 2016
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Slovák L., Poništ S., Kuncírová V., Mihalová D., Fedorova T., Bauerová K.   +5 more
doaj   +1 more source