Results 91 to 100 of about 1,450,510 (208)

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: a systematic review and meta analysis

, 2021
Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: a systematic review and meta ...
A Hadi (9865631), Olivia Dean (13088112), G Clarke (10884156), L Staskova (13467654), Michael Berk (13060851), Adrienne O'Neil (13088034), C Honan (13467657), Madi West (13083627), Wolf Marx (13100121), J Firth (7655666), Maree Lane (15903797), JF Cryan (10884159), T Purton (13467651), Samantha Dawson (13066098)   +13 more
core  

Urinary and Faecal Amino‐Acids as Biomarkers for Colorectal Neoplasia in Lynch Syndrome—A Prospective Longitudinal Study

International Journal of Cancer, EarlyView.
ABSTRACT In Lynch syndrome, colonoscopy surveillance for colorectal cancer (CRC) is burdensome and post‐colonoscopy CRCs still occur. Unlike the faecal immunochemical test (FIT), gut metabolomic alterations including amino‐acids have shown potential as non‐invasive biomarkers for detecting both advanced and non‐advanced sporadic colorectal neoplasia ...
Roza C. M. Opperman, Elsa L. S. A. van Liere, Animesh Acharjee, Sudip Mondal, Eduard A. Struys, Andreas Antoniadis, Jasmijn E. B. de Boer, Shivra R. Siriram, Abdellatif Bakkali, Sofie Bosch, Maarten A. J. M. Jacobs, Jan Jacob Koornstra, Johan P. Kuijvenhoven, Monique E. van Leerdam, Manon C. W. Spaander, Tim G. J. de Meij, Evelien Dekker, Dewkoemar Ramsoekh, Nanne K. H. de Boer   +18 more
wiley   +1 more source

Impact of Substance Use Disorder on Tryptophan Metabolism Through the Kynurenine Pathway: A Narrative Review

Metabolites
Background/Objectives: Substance use disorder is a crisis impacting many people in the United States. This review aimed to identify the effect addictive substances have on the kynurenine pathway.
Lindsey Contella, Christopher L. Farrell, Luigi Boccuto, Alain H. Litwin, Marion L. Snyder   +4 more
doaj   +1 more source

Impaired Kynurenine Pathway in Inflammatory Bowel Disease

Background/Objectives: Inflammatory bowel diseases primarily encompass Crohn’s disease and ulcerative colitis. Insufficient levels of tryptophan cause an imbalance in the gut microbiota, leading to inflammation in the gastrointestinal tract.
Kubra Bozalı, Muslu Kazım Körez, Metin Basaranoglu, Hakan Vatansev, Husamettin Vatansev, Eray Metin Guler, Esra Paydaş Hataysal   +6 more
core   +1 more source

Metabolism of tryptophan along the kynurenine pathway in alloxan diabetic rabbits

, 2002
In vivo study of the metabolism of tryptophan along the kynurenine pathway in alloxan diabetic ...
ALLEGRI, GRAZIELLA, Guglielmina Froldi, COSTA, CARLO VIRGILIO LUIGI, G. ALLEGRI, Eugenio Ragazzi, Delia Zaccarin, FROLDI, GUGLIELMINA, C.V.L. COSTA, BERTAZZO, ANTONELLA, Carlo V.L. Costa, D. ZACCARIN, ZACCARIN D, RAGAZZI, EUGENIO, Graziella Allegri, Antonella Bertazzo, A. BERTAZZO   +15 more
core   +1 more source

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles, Schwarz, J.M., Berfelo, M. W., M. Schwarz, Vles, J. S. H., Schwarz, M., Hulsman, J. A. R. J., A. Myint, Majoie, H. J. M., M.W. Berfelo, Hulsman, J.A.R.J., K. Rijkers, Myint, A., J.A.R.J. Hulsman, Rijkers, K., H.J.M. Majoie   +15 more
core   +1 more source

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source