Tryptophan metabolism is a physiological integrator regulating circadian rhythms [PDF]
Molecular Metabolism, 2022 Objective: The circadian clock aligns physiology with the 24-hour rotation of Earth. Light and food are the main environmental cues (zeitgebers) regulating circadian rhythms in mammals.
Paul Petrus
exaly +4 more sources
TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome
Metabolites, 2021 Crosstalk between the gut microbiome and the host plays an important role in animal development and health. Small compounds are key mediators in this host–gut microbiome dialogue.
Yao Lu +5 more
doaj +2 more sources
Tryptophan metabolism: A hidden regulator of female reproductive health beyond fertility [PDF]
Chinese Medical Journal. Female reproductive health encompasses fertility, safe pregnancy and childbirth, and is vital throughout the entire life of women. Tryptophan, an essential amino acid in humans, is involved in protein synthesis and the generation of bioactive ...
Qingyang Wu +4 more
doaj +2 more sources
Tryptophan metabolism in depression [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1970 Psychiatric patients suffering from endogenous depression and a control group without endogenous depression were given oral loads of L-tryptophan and urinary excretion determined of the tryptophan metabolites on the pyrrolase pathway: kynurenine, 3-hydroxykynurenine, and 3-hydroxyanthranilic acid.
G, Curzon, P K, Bridges
openaire +3 more sources
Identification and characterization of tryptophan metabolism-related genes in carotid artery plaques. [PDF]
PLoS ONECardiovascular and cerebrovascular diseases, often caused by atherosclerosis, are the stern cause of death worldwide, and carotid plaque play a crucial role in the development of these diseases.
Xiaodong Jia +8 more
doaj +2 more sources
MetabolitesBackground: The early nutritional metabolism of piglets is intimately associated with the regulation of immune function, and amino acids play a crucial role in modulating the fate and function of porcine immune cells, especially macrophages. However, the
Meimei Zhang +3 more
doaj +2 more sources
Role of Tryptophan Metabolism in Cancer. [PDF]
Cancer InnovABSTRACT Tryptophan (Trp) is an essential amino acid that serves as a precursor for the synthesis of several important bioactive compounds. Trp is involved in a variety of pathophysiological processes, including neuronal function, metabolism, inflammatory responses, oxidative stress, immune regulation, and intestinal homeostasis.
Cui Z +5 more
europepmc +3 more sources
Altered tryptophan metabolism as a contributor to cognitive impairment in chronic kidney disease: a narrative review [PDF]
Frontiers in NeuroscienceApproximately 40% of patients with chronic kidney disease (CKD) experience cognitive impairment (CI), which is strongly associated with increased mortality.
Harish Selvaraj +5 more
doaj +2 more sources
Microbial tryptophan metabolism activates host lysosomal activity to facilitate lipid breakdown. [PDF]
PLoS BiologyLysosomes are central to lipid metabolism, yet how gut microbiota-derived metabolites regulate lysosomal function to influence host lipid homeostasis remains unknown.
Kenan Zhang +10 more
doaj +2 more sources
Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs
Animal Nutrition, 2022 Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu +9 more
doaj +1 more source