Identification and characterization of tryptophan metabolism-related genes in carotid artery plaques. [PDF]
PLoS ONECardiovascular and cerebrovascular diseases, often caused by atherosclerosis, are the stern cause of death worldwide, and carotid plaque play a crucial role in the development of these diseases.
Xiaodong Jia +8 more
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Microbial tryptophan metabolism activates host lysosomal activity to facilitate lipid breakdown. [PDF]
PLoS BiologyLysosomes are central to lipid metabolism, yet how gut microbiota-derived metabolites regulate lysosomal function to influence host lipid homeostasis remains unknown.
Kenan Zhang +10 more
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Deciphering tryptophan metabolism in colorectal cancer through multi-omics analysis [PDF]
Biochemistry and Biophysics ReportsMetabolic reprogramming is essential for colorectal cancer (CRC) progression, and recent studies have pointed to tryptophan metabolism as a crucial modulator of the tumor immune microenvironment.
Chengcheng Zhang +14 more
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Tryptophan metabolism reprogramming regulates Th1/Th2 immune balance and inhibits mast cell activation [PDF]
Amino AcidsAsthma is characterized by chronic airway inflammation and an imbalanced Th1/Th2 response. Although tryptophan metabolism has been implicated in immune regulation, its direct influence on Th1/Th2 differentiation and mast-cell activation remains ...
Dongsheng Huang +9 more
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Interactions between gut microbiota and parkinson’s disease: the role of tryptophan metabolism [PDF]
Cell Communication and SignalingParkinson’s disease, a common neurodegenerative disorder in the elderly, is characterized by motor symptoms and non-motor symptoms such as anxiety, depression, sleep disturbances, and gastrointestinal dysfunction, highlighting its nature as a multisystem
Xuemei Fan +6 more
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Seasonal Plasticity in Tryptophan Metabolism Provides New Insights Into Physiological Adaptation in Snake Hibernation [PDF]
Ecology and EvolutionHibernation is a common behavioral strategy for snakes to cope with extreme environments. This phenomenon has raised important scientific questions regarding its physiological adaptation mechanisms. Although tryptophan and its metabolites have been widel
Yuting Wei +10 more
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Immune regulation through tryptophan metabolism
Experimental and Molecular Medicine, 2023 Amino acids are fundamental units of molecular components that are essential for sustaining life; however, their metabolism is closely interconnected to the control systems of cell function.
Su-Kil Seo, Byungsuk Kwon
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Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs
Animal Nutrition, 2022 Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu +9 more
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Tryptophan metabolism is a physiological integrator regulating circadian rhythms
Molecular Metabolism, 2022 Objective: The circadian clock aligns physiology with the 24-hour rotation of Earth. Light and food are the main environmental cues (zeitgebers) regulating circadian rhythms in mammals.
Paul Petrus +17 more
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TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome
Metabolites, 2021 Crosstalk between the gut microbiome and the host plays an important role in animal development and health. Small compounds are key mediators in this host–gut microbiome dialogue.
Yao Lu +5 more
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