Deciphering tryptophan metabolism in colorectal cancer through multi-omics analysis [PDF]
Biochemistry and Biophysics ReportsMetabolic reprogramming is essential for colorectal cancer (CRC) progression, and recent studies have pointed to tryptophan metabolism as a crucial modulator of the tumor immune microenvironment.
Chengcheng Zhang +14 more
doaj +4 more sources
Tryptophan metabolism is a physiological integrator regulating circadian rhythms [PDF]
Molecular Metabolism, 2022 Objective: The circadian clock aligns physiology with the 24-hour rotation of Earth. Light and food are the main environmental cues (zeitgebers) regulating circadian rhythms in mammals.
Paul Petrus +17 more
doaj +5 more sources
Identification and characterization of tryptophan metabolism-related genes in carotid artery plaques. [PDF]
PLoS ONECardiovascular and cerebrovascular diseases, often caused by atherosclerosis, are the stern cause of death worldwide, and carotid plaque play a crucial role in the development of these diseases.
Xiaodong Jia +8 more
doaj +2 more sources
Role of Tryptophan Metabolism in Cancer. [PDF]
Cancer InnovABSTRACT Tryptophan (Trp) is an essential amino acid that serves as a precursor for the synthesis of several important bioactive compounds. Trp is involved in a variety of pathophysiological processes, including neuronal function, metabolism, inflammatory responses, oxidative stress, immune regulation, and intestinal homeostasis.
Cui Z +5 more
europepmc +3 more sources
Microbial tryptophan metabolism activates host lysosomal activity to facilitate lipid breakdown. [PDF]
PLoS BiologyLysosomes are central to lipid metabolism, yet how gut microbiota-derived metabolites regulate lysosomal function to influence host lipid homeostasis remains unknown.
Kenan Zhang +10 more
doaj +2 more sources
Interactions between gut microbiota and parkinson’s disease: the role of tryptophan metabolism [PDF]
Cell Communication and SignalingParkinson’s disease, a common neurodegenerative disorder in the elderly, is characterized by motor symptoms and non-motor symptoms such as anxiety, depression, sleep disturbances, and gastrointestinal dysfunction, highlighting its nature as a multisystem
Xuemei Fan +6 more
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Tryptophan metabolism reprogramming regulates Th1/Th2 immune balance and inhibits mast cell activation [PDF]
Amino AcidsAsthma is characterized by chronic airway inflammation and an imbalanced Th1/Th2 response. Although tryptophan metabolism has been implicated in immune regulation, its direct influence on Th1/Th2 differentiation and mast-cell activation remains ...
Dongsheng Huang +9 more
doaj +2 more sources
The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut
Cell ReportsSummary: Chronic stress disrupts microbiota-gut-brain axis function and is associated with altered tryptophan metabolism, impaired gut barrier function, and disrupted diurnal rhythms.
Cassandra E. Gheorghe +12 more
doaj +3 more sources
Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs
Animal Nutrition, 2022 Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu +9 more
doaj +1 more source
Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders
Frontiers in Immunology, 2022 Neurological and psychiatric disorders are a category of chronic diseases that are widespread and pose serious mental and physical health problems for patients.
Dan Li +12 more
doaj +1 more source