The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut
Cell ReportsSummary: Chronic stress disrupts microbiota-gut-brain axis function and is associated with altered tryptophan metabolism, impaired gut barrier function, and disrupted diurnal rhythms.
Cassandra E. Gheorghe +12 more
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Tryptophan metabolism is a physiological integrator regulating circadian rhythms [PDF]
Molecular Metabolism, 2022 Objective: The circadian clock aligns physiology with the 24-hour rotation of Earth. Light and food are the main environmental cues (zeitgebers) regulating circadian rhythms in mammals.
Paul Petrus +17 more
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Tryptophan metabolism: A hidden regulator of female reproductive health beyond fertility [PDF]
Chinese Medical Journal. Female reproductive health encompasses fertility, safe pregnancy and childbirth, and is vital throughout the entire life of women. Tryptophan, an essential amino acid in humans, is involved in protein synthesis and the generation of bioactive ...
Qingyang Wu +4 more
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TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome
Metabolites, 2021 Crosstalk between the gut microbiome and the host plays an important role in animal development and health. Small compounds are key mediators in this host–gut microbiome dialogue.
Yao Lu +5 more
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Identification and characterization of tryptophan metabolism-related genes in carotid artery plaques. [PDF]
PLoS ONECardiovascular and cerebrovascular diseases, often caused by atherosclerosis, are the stern cause of death worldwide, and carotid plaque play a crucial role in the development of these diseases.
Xiaodong Jia +8 more
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Altered tryptophan metabolism as a contributor to cognitive impairment in chronic kidney disease: a narrative review [PDF]
Frontiers in NeuroscienceApproximately 40% of patients with chronic kidney disease (CKD) experience cognitive impairment (CI), which is strongly associated with increased mortality.
Harish Selvaraj +5 more
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Microbial tryptophan metabolism activates host lysosomal activity to facilitate lipid breakdown. [PDF]
PLoS BiologyLysosomes are central to lipid metabolism, yet how gut microbiota-derived metabolites regulate lysosomal function to influence host lipid homeostasis remains unknown.
Kenan Zhang +10 more
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Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs
Animal Nutrition, 2022 Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu +9 more
doaj +1 more source
Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders
Frontiers in Immunology, 2022 Neurological and psychiatric disorders are a category of chronic diseases that are widespread and pose serious mental and physical health problems for patients.
Dan Li +12 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 BackgroundsGut microbiota plays a critical role in the onset and development of depression, but the underlying molecular mechanisms are unclear. This study was conducted to explore the relationships between gut microbiota and host’s metabolism in ...
Jing Xie +8 more
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