TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome
Metabolites, 2021 Crosstalk between the gut microbiome and the host plays an important role in animal development and health. Small compounds are key mediators in this host–gut microbiome dialogue.
Yao Lu +5 more
doaj +2 more sources
Tryptophan metabolism is a physiological integrator regulating circadian rhythms [PDF]
Molecular Metabolism, 2022 Objective: The circadian clock aligns physiology with the 24-hour rotation of Earth. Light and food are the main environmental cues (zeitgebers) regulating circadian rhythms in mammals.
Paul Petrus +17 more
doaj +3 more sources
Tryptophan metabolism in depression [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1970 Psychiatric patients suffering from endogenous depression and a control group without endogenous depression were given oral loads of L-tryptophan and urinary excretion determined of the tryptophan metabolites on the pyrrolase pathway: kynurenine, 3-hydroxykynurenine, and 3-hydroxyanthranilic acid.
G, Curzon, P K, Bridges
openaire +3 more sources
The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut
Cell ReportsSummary: Chronic stress disrupts microbiota-gut-brain axis function and is associated with altered tryptophan metabolism, impaired gut barrier function, and disrupted diurnal rhythms.
Cassandra E. Gheorghe +12 more
doaj +3 more sources
New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis
Frontiers in ImmunologyArginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage polarization and immune activation. Specifically, interferon-gamma (IFN-γ) stimulates inducible nitric oxide synthase (iNOS) expression), leading to the conversion of ...
Kangling Zhang +2 more
doaj +3 more sources
Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs
Animal Nutrition, 2022 Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu +9 more
doaj +1 more source
Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders
Frontiers in Immunology, 2022 Neurological and psychiatric disorders are a category of chronic diseases that are widespread and pose serious mental and physical health problems for patients.
Dan Li +12 more
doaj +1 more source
A Defect in Tryptophan Metabolism [PDF]
Pediatric Research, 1976 Oral tryptophan loading tests were performed in a patient with photosensitive pellagra-like skin rash and cerebellar ataxia but without hyperaminoaciduria. Plasma tryptophan concentrations after loading were similar in the patient and control subjects.
P W, Wong +3 more
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2023 BackgroundsGut microbiota plays a critical role in the onset and development of depression, but the underlying molecular mechanisms are unclear. This study was conducted to explore the relationships between gut microbiota and host’s metabolism in ...
Jing Xie +8 more
doaj +1 more source
Metabonomic Study of the Involvement of the Intestinal Microflora in the Improvement of Iron Deficiency Anemia (IDA) by Auricularia auricula Melanin in Mice [PDF]
Shipin Kexue, 2023 Iron deficiency anemia (IDA) is a common iron deficiency disease. IDA has become one of the major public health problems worldwide. Our previous studies have shown that Auricularia auricula melanin (AAM) can alleviate IDA, but the mechanism is not clear.
WANG Yuting, LI Yuanjing, CHU Fuying, SHI Shuliang, LEI Hong, FENG Lei
doaj +1 more source