Interactions between Tryptophan Metabolism, the Gut Microbiome and the Immune System as Potential Drivers of Non-Alcoholic Fatty Liver Disease (NAFLD) and Metabolic Diseases [PDF]
, 2022 The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and therefore is its burden of disease as NALFD is a risk factor for cirrhosis and is associated with other metabolic conditions such as type II diabetes, obesity, dyslipidaemia ...
Max Nieuwdorp +5 more
core +1 more source
Changes in Tryptophan Metabolism on Serotonin and Kynurenine Pathways in Patients with Irritable Bowel Syndrome [PDF]
, 2023 (1) Background: L-tryptophan is a substrate for the synthesis of many biological compounds through the serotonin and kynurenine pathways. These compounds have a significant influence on gastrointestinal functions and mental processes.
Cezary Chojnacki +5 more
core +1 more source
Metabonomic Study of the Involvement of the Intestinal Microflora in the Improvement of Iron Deficiency Anemia (IDA) by Auricularia auricula Melanin in Mice [PDF]
Shipin Kexue, 2023 Iron deficiency anemia (IDA) is a common iron deficiency disease. IDA has become one of the major public health problems worldwide. Our previous studies have shown that Auricularia auricula melanin (AAM) can alleviate IDA, but the mechanism is not clear.
WANG Yuting, LI Yuanjing, CHU Fuying, SHI Shuliang, LEI Hong, FENG Lei
doaj +1 more source
SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism [PDF]
, 2021 Coronavirus disease 2019 (COVID-19) has so far infected hundreds of million individuals, with several million deaths worldwide. The lack of understanding of the disease pathophysiology and the host’s immune response has resulted in this rapid spread of ...
Xiangming Ji +2 more
core +1 more source
Association between Tryptophan Metabolism and Inflammatory Biomarkers in Dairy Cows with Ketosis [PDF]
, 2023 Dairy cows with ketosis have high circulating beta-hydroxybutyric acid (BHBA) concentrations alongside which inflammation is concomitantly developed.
Xueping Yao +10 more
core +1 more source
Tryptophan metabolism in bipolar disorder
European Psychiatry, 2022 Introduction Immune mediated inflammatory processes are involved in the aetiopathogenesis of bipolar disorder (BD) and weight associated comorbidities. Tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) along the kynurenine axis concomitant ...
F. Fellendorf +11 more
doaj +1 more source
Tryptophan Metabolism in Alcoholism [PDF]
Nutrition Research Reviews, 1999 Studies of tryptophan (Trp) metabolism in relation to the serotonin status in alcoholism are of 2 types: (1) those related to the pharmacological effects of ethanol; (2) those concerning the serotonin status in the absence of alcohol intake. In experimental animals, acute and chronic ethanol administration and subsequent withdrawal exert a variety of ...
openaire +3 more sources
Structural insights into the basis and evolution of interactions in multi-subunit protein assemblies. tryptophan synthase and titin FNIII-repeats [PDF]
, 2008 Cellular processes benefit from evolutionary shaping when optimized protein-protein interactions result in enhanced functionality. In fact, most cellular proteins are tightly embedded into biological networks that function following a modularity ...
Bucher, Rainer Michael
core +1 more source
Metabolites, 2023 Tryptophan metabolism and gut microbiota form an integrated regulatory axis that impacts immunity, metabolism, and cancer. This review consolidated current knowledge on the bidirectional interactions between microbial tryptophan processing and the host ...
Yingjian Hou, Jing Li, Shuhuan Ying
doaj +1 more source
Biomolecules, 2022 Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan ...
Knut Hestad +3 more
doaj +1 more source