Results 21 to 30 of about 1,036,536 (283)
Metabolites, 2023 Tryptophan metabolism and gut microbiota form an integrated regulatory axis that impacts immunity, metabolism, and cancer. This review consolidated current knowledge on the bidirectional interactions between microbial tryptophan processing and the host ...
Yingjian Hou, Jing Li, Shuhuan Ying
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Structural insights into the basis and evolution of interactions in multi-subunit protein assemblies. tryptophan synthase and titin FNIII-repeats [PDF]
, 2008 Cellular processes benefit from evolutionary shaping when optimized protein-protein interactions result in enhanced functionality. In fact, most cellular proteins are tightly embedded into biological networks that function following a modularity ...
Bucher, Rainer Michael
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Biomolecules, 2022 Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan ...
Knut Hestad +3 more
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, 2022 The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and therefore is its burden of disease as NALFD is a risk factor for cirrhosis and is associated with other metabolic conditions such as type II diabetes, obesity, dyslipidaemia ...
Max Nieuwdorp +5 more
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, 2022 The obesity epidemic has contributed to an escalating prevalence of metabolic diseases in children. Overnutrition leads to increased tryptophan uptake and availability.
Julia Lischka +5 more
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The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism
Metabolites, 2023 Tryptophan is metabolized along three main metabolic pathways, namely the kynurenine, serotonin and indole pathways. The majority of tryptophan is transformed via the kynurenine pathway, catalyzed by tryptophan-2,3-dioxygenase or indoleamine-2,3 ...
Anna Haduch +3 more
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Microorganisms, 2021 Akkermansia muciniphila, a potential probiotic, has been proven to lessen the effects of several diseases. As established, the relative abundance of Akkermansia is positively correlated with tryptophan metabolism.
Jia Yin +7 more
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Frontiers in Pharmacology, 2023 Introduction: The 5-year survival of gastric cancer (GC) patients with advanced stage remains poor. Some evidence has indicated that tryptophan metabolism may induce cancer progression through immunosuppressive responses and promote the malignancy of ...
Peng Luo +6 more
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Tryptophan metabolites in depression: Modulation by gut microbiota
Frontiers in Behavioral Neuroscience, 2022 Clinical depression is a multifactorial disorder and one of the leading causes of disability worldwide. The alterations in tryptophan metabolism such as changes in the levels of serotonin, kynurenine, and kynurenine acid have been implicated in the ...
Iva Lukić +3 more
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, 2023 (1) Background: L-tryptophan is a substrate for the synthesis of many biological compounds through the serotonin and kynurenine pathways. These compounds have a significant influence on gastrointestinal functions and mental processes.
Cezary Chojnacki +5 more
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