Results 31 to 40 of about 1,036,536 (283)
Nature Communications, 2023 The upstream metabolism of tryptophan has been described as a metabolic node in glioblastoma. Here the authors show that the downstream metabolism of tryptophan, resulting in the accumulation of quinolinate in glioblastoma, contributes to pro-tumorigenic
Pravin Kesarwani +6 more
doaj +1 more source
Evolution of substrate specificity in a recipient's enzyme following horizontal gene transfer [PDF]
, 2013 Despite the prominent role of horizontal gene transfer (HGT) in shaping bacterial metabolism, little is known about the impact of HGT on the evolution of enzyme function.
Noda-Garcia, Lianet +6 more
core +1 more source
Association between Tryptophan Metabolism and Inflammatory Biomarkers in Dairy Cows with Ketosis
, 2023 Dairy cows with ketosis have high circulating beta-hydroxybutyric acid (BHBA) concentrations alongside which inflammation is concomitantly developed.
Xueping Yao +10 more
core +1 more source
Disturbed amino acid metabolism in HIV: association with neuropsychiatric symptoms
Frontiers in Psychiatry, 2015 Blood levels of the amino acid phenylalanine, as well as of the tryptophan breakdown product kynurenine, are found to be elevated in human immunodeficiency virus type 1 (HIV-1)-infected patients.
Johanna M Gostner +3 more
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Immune regulation through tryptophan metabolism
Experimental and Molecular Medicine, 2023 Amino acids are fundamental units of molecular components that are essential for sustaining life; however, their metabolism is closely interconnected to the control systems of cell function.
Su-Kil Seo, Byungsuk Kwon
doaj +1 more source
Deciphering tryptophan metabolism in colorectal cancer through multi-omics analysis
Biochemistry and Biophysics ReportsMetabolic reprogramming is essential for colorectal cancer (CRC) progression, and recent studies have pointed to tryptophan metabolism as a crucial modulator of the tumor immune microenvironment.
Chengcheng Zhang +14 more
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Frontiers in MedicineBackgroundInflammatory bowel disease is an incurable and idiopathic disease characterized by recurrent gastrointestinal tract inflammation. Tryptophan metabolism in mammalian cells and some gut microbes comprise intricate chemical networks facilitated by
Jeannie Devereaux +15 more
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SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism
, 2021 Coronavirus disease 2019 (COVID-19) has so far infected hundreds of million individuals, with several million deaths worldwide. The lack of understanding of the disease pathophysiology and the host’s immune response has resulted in this rapid spread of ...
Xiangming Ji +2 more
core +1 more source
Tryptophan plays an important role in yeast’s tolerance to isobutanol
Biotechnology for Biofuels, 2021 Background Isobutanol is considered a potential biofuel, thanks to its high-energy content and octane value, limited water solubility, and compatibility with gasoline.
Hsien-Lin Liu +4 more
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Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
Frontiers in Microbiology, 2021 Host metabolism has recently gained more attention for its roles in physiological functions and pathologic conditions. Of these, metabolic tryptophan disorders generate a pattern of abnormal metabolites that are implicated in various diseases.
Xiaolei Wang +4 more
doaj +1 more source