Results 31 to 40 of about 10,379 (248)
Nature Communications, 2023 The upstream metabolism of tryptophan has been described as a metabolic node in glioblastoma. Here the authors show that the downstream metabolism of tryptophan, resulting in the accumulation of quinolinate in glioblastoma, contributes to pro-tumorigenic
Pravin Kesarwani +6 more
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Evolution of substrate specificity in a recipient's enzyme following horizontal gene transfer [PDF]
, 2013 Despite the prominent role of horizontal gene transfer (HGT) in shaping bacterial metabolism, little is known about the impact of HGT on the evolution of enzyme function.
Noda-Garcia, Lianet +6 more
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Frontiers in MedicineBackgroundInflammatory bowel disease is an incurable and idiopathic disease characterized by recurrent gastrointestinal tract inflammation. Tryptophan metabolism in mammalian cells and some gut microbes comprise intricate chemical networks facilitated by
Jeannie Devereaux +15 more
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Immune regulation through tryptophan metabolism
Experimental and Molecular Medicine, 2023 Amino acids are fundamental units of molecular components that are essential for sustaining life; however, their metabolism is closely interconnected to the control systems of cell function.
Su-Kil Seo, Byungsuk Kwon
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Tryptophan Metabolism in Allergic Disorders [PDF]
International Archives of Allergy and Immunology, 2016 Allergic diseases such as asthma and rhinitis, as well the early phase of atopic dermatitis, are characterized by a Th2-skewed immune environment. Th2-type cytokines are upregulated in allergic inflammation, whereas there is downregulation of the Th1-type immune response and related cytokines, such as interferon-γ (IFN-γ).
Johanna M, Gostner +4 more
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Tryptophan plays an important role in yeast’s tolerance to isobutanol
Biotechnology for Biofuels, 2021 Background Isobutanol is considered a potential biofuel, thanks to its high-energy content and octane value, limited water solubility, and compatibility with gasoline.
Hsien-Lin Liu +4 more
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Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
Frontiers in Microbiology, 2021 Host metabolism has recently gained more attention for its roles in physiological functions and pathologic conditions. Of these, metabolic tryptophan disorders generate a pattern of abnormal metabolites that are implicated in various diseases.
Xiaolei Wang +4 more
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Metabolism of tryptophan along the kynurenine pathway in alloxan diabetic rabbits
, 2002 In vivo study of the metabolism of tryptophan along the kynurenine pathway in alloxan diabetic ...
ALLEGRI, GRAZIELLA +15 more
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Circadian periodicity of tryptophan metabolism [PDF]
Journal of Clinical Investigation, 1968 Rhythmicity of tryptophan metabolism via the kynurenine pathway has been demonstrated in man. Normal subjects given 3 g of tryptophan at 0900 hours excreted almost three times the quantity of kynurenine, kynurenic acid, and xanthurenic acid than did subjects given the same dose at 2100 hours.
M I, Rapoport, W R, Beisel
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Tryprophan metbolism in alcoholism. Tryptophan but not excitatory amino acid availablity to the brain is increased before the appearance of the alcohol-withdrawal syndrome in men [PDF]
, 1998 Tryptophan (Trp) metabolism and disposition and excitatory and other amino acid concentrations were determined in alcohol-dependent subjects in relation to the alcohol-withdrawal syndrome (AWS).
Morgan, Christopher J. +7 more
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