Results 1 to 10 of about 87,880 (172)

The metabolic‐immune hub: Dual roles of indoleamine 2,3‐dioxygenase in the acute kidney injury‐to‐chronic kidney disease transition and therapeutic perspectives

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
1. Indoleamine 2,3‐dioxygenase (IDO) acts as a time‐dependent metabolic–immune switch in the acute kidney injury‐to‐chronic kidney disease transition, protective early but pathogenic when sustained. 2. Early protection (regulatory T cell expansion, M2 polarisation and ferroptosis suppression) gives way to general control nonderepressible 2‐driven ...
Ziyi Qiu, Binbin Pan
wiley   +1 more source

Studies on the Interaction of Carbon Monoxide with Tryptophan Oxygenase of Pseudomonas

Journal of Biological Chemistry, 1968
Abstract 1. The inhibition of Pseudomonas tryptophan oxygenase by carbon monoxide is competitive with respect to oxygen and is photodissociable. The photochemical action spectrum, with a maximum at 421 mµ, is identical with the Soret absorption spectrum of the tryptophan-carboxyferroprotoporphyrin-enzyme complex.
H, Maeno, P, Feigelson
openaire   +2 more sources

Network Pharmacology Combined With Metabonomics and Transcriptomics Reveals the Mechanism of Rubus Chingii Hu in Alleviating Nephrotoxicity Caused by Tripterygium Glycosides Tablet

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Flow chart of RCH to improve TGT‐induced nephrotoxicity. ABSTRACT Researches on Tripterygium glycosides tablets (TGT) often overlook renal toxicity from prolonged use. Rubus chingii Hu (RCH) is beneficial to kidney health and has an unclear role in reducing nephrotoxicity.
Cong Zhang, Zepeng Zhang, Tong Zhou, Lei Zhang   +3 more
wiley   +1 more source

pH dependence of the cooperative interactions and conformation of tryptophan oxygenase

Journal of Biological Chemistry, 1975
Allosteric interactions in the cupro-heme enzyme tryptophan oxygenase (EC 1.13.11.11) of Pseudomonas acidovorans are shown to be pH-dependent. Increasing the assay pH from 6.0 to 8.0 progressively desensitizes the enzyme from both homotropic and heterotropic ligand interactions. This pH-dependent reversible transition has a pK of 6.2. Hill coefficients
P D, Colman, S P, Blanchet, E, Chow, P, Feigelson   +3 more
openaire   +2 more sources

Tryptophan metabolism in liver transplantation immune tolerance. [PDF]

Front Immunol
Li W, Ren A.
europepmc   +1 more source

Tryptophan Oxygenase of Pseudomonas acidovorans

Journal of Biological Chemistry, 1969
W N Poillon, H Maeno, K Koike, P Feigelson   +3 more
openaire   +1 more source

Participation of redox-active residues in polysaccharide monooxygenase catalysis. [PDF]

RSC Chem Biol
Batka AE, Bhat A, Rose AJ, Marletta MA.
europepmc   +1 more source

Discovery of the 5-Chlorokynurenine Pathway in Lodopyridone Biosynthesis. [PDF]

J Nat Prod
Avila MJ, Lan T, Moore BS.
europepmc   +1 more source

Chlorophyll <i>b</i>-An Essence of Plant Photosynthesis. [PDF]

Plants (Basel)
Hoober JK, Eggink LL, Bednarik DP, Reinbothe S.   +3 more
europepmc   +1 more source

Heme oxygenase-like dimetal oxidases and oxygenases. [PDF]

Biochem Soc Trans
Skirboll SS, Ledinina AE, Makris TM.
europepmc   +1 more source