Results 1 to 10 of about 164,842 (161)

Radical <i>S</i>-Adenosyl-l-Methionine Oxygenase DarE Forms Ether Bond via a Partially Delocalized Tryptophan C_β Radical. [PDF]

J Am Chem Soc
Darobactins are ribosomally synthesized and post-translationally modified peptides (RiPPs) with potent activity against Gram-negative pathogens. Their antibiotic function depends on a distinctive β-strand architecture stabilized by an ether crosslink ...
Nguyen BX, Bollmeyer MM, Nguyen H, Milikisiyants S, Smirnov AI, Britt RD, Yokoyama K.   +6 more
europepmc   +2 more sources

The Prematurely Evoked Synthesis of Liver Tryptophan Oxygenase [PDF]

Proceedings of the National Academy of Sciences, 1971
Livers of normal rats are devoid of catalytically or immunochemically reactive tryptophan oxygenase (EC 1.13.1.12) up to the 10th postnatal day; the enzyme reaches adult concentrations on about the twentieth day. Premature tryptophan oxygenase synthesis can be evoked in 4-day-old rats: if an injection of glucocorticoid is followed, a day later, by an ...
O, Greengard, H K, Dewey
openaire   +3 more sources

Deciphering Tryptophan Oxygenation: Key Modulators of 2-Oxindole Formation in MarE. [PDF]

Angew Chem Int Ed Engl
MarE, a heme‐dependent aromatic oxygenase with a histidyl axial ligation, catalyzes the monooxygenation of β‐methyl‐l‐tryptophan to form a 2‐oxindole scaffold central to maremycin biosynthesis. Although structurally similar to tryptophan 2,3‐dioxygenase (
Nguyen RC, Shin I, Liu A.
europepmc   +2 more sources

Isolation and characterization of the rat tryptophan oxygenase gene. [PDF]

The EMBO Journal, 1982
Tryptophan oxygenase (TO, EC 1.13.1.12) from rat liver is subject to glucocorticoid and developmental control. To study the mechanism of regulation, TO mRNA sequences and the chromosomal TO gene were cloned. From a cDNA library prepared from rat liver poly(A)+ RNA enriched for TO mRNA, a recombinant plasmid containing TO cDNA sequences was identified ...
W, Schmid, G, Scherer, U, Danesch, H, Zentgraf, P, Matthias, C M, Strange, W, Röwekamp, G, Schütz   +7 more
openaire   +3 more sources

Single-Enzyme Conversion of Tryptophan to Skatole and Cyanide Expands the Mechanistic Competence of Diiron Oxidases. [PDF]

J Am Chem Soc
Skatole is a pungent heterocyclic compound derived from the essential amino acid l-tryptophan by bacteria in the mammalian digestive tract. The four-step anaerobic conversion of tryptophan to skatole is well-established; though, to date, no aerobic ...
Adak S, Calderone LA, Krueger A, Pandelia ME, Moore BS.   +4 more
europepmc   +2 more sources

Spectral Studies on the Catalytic Mechanism and Activation of Pseudomonas Tryptophan Oxygenase (Tryptophan Pyrrolase)

Journal of Biological Chemistry, 1967
1. The substrate, tryptophan, forms spectrophotometrically detectable enzyme-substrate complexes with tryptophan oxygenase (EC 1.13.1.12)—commonly known as tryptophan pyrrolase—when the iron atom of the heme prosthetic group is either divalent, trivalent, or combined with carbon monoxide. 2.
H, Maeno, P, Feigelson
openaire   +3 more sources

Novel immune cell infiltration-related biomarkers in atherosclerosis diagnosis [PDF]

PeerJ, 2023
Background Immune cell infiltration (ICI) has a close relationship with the progression of atherosclerosis (AS). Therefore, the current study was aimed to explore the role of genes related to ICI and to investigate potential mechanisms in AS.
Ruoyu Dong, Jikuan Li, Guangwei Jiang, Ning Han, Yaochao Zhang, Xiaoming Shi   +5 more
doaj   +2 more sources

Detoxification of Indole by an Indole-Induced Flavoprotein Oxygenase from Acinetobacter baumannii. [PDF]

PLoS ONE, 2015
Indole, a derivative of the amino acid tryptophan, is a toxic signaling molecule, which can inhibit bacterial growth. To overcome indole-induced toxicity, many bacteria have developed enzymatic defense systems to convert indole to non-toxic, water ...
Guang-Huey Lin, Hao-Ping Chen, Hung-Yu Shu   +2 more
doaj   +1 more source

Beneficial or detrimental activity of regulatory T cells, indoleamine 2,3-dioxygenase, and heme oxygenase-1 in the lungs is influenced by the level of virulence of Mycobacterium tuberculosis strain infection

Frontiers in Cellular and Infection Microbiology, 2023
Tuberculosis (TB) caused by the complex Mycobacterium tuberculosis (Mtb) is the main cause of death by a single bacterial agent. Last year, TB was the second leading infectious killer after SARS-CoV-2.
Vasti Lozano-Ordaz, Yadira Rodriguez-Miguez, Angel E. Ortiz-Cabrera, Sujhey Hernandez-Bazan, Dulce Mata-Espinosa, Jorge Barrios-Payan, Rafael Saavedra, Rogelio Hernandez-Pando   +7 more
doaj   +1 more source

HEME OXYGENASE-1 UPREGULATED BY MELATONIN: POTENTIAL PROTECTION AGAINST BURN-INDUCED OXIDATIVE GASTRIC MUCOSAL INJURY. [PDF]

Journal of IMAB, 2015
Melatonin is indoleamine hormone derived from L-tryptophan. Due to its lipophilic nature, it is accessible to every cell. Melatonin has immunomodulatory and antioxidant activities thus protecting tissue injury.
Minka Hristova, Ganka Bekyarova, Maria Tzaneva   +2 more
doaj   +1 more source