Results 21 to 30 of about 164,861 (180)

A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile

Nature Chemistry
Nitriles are uncommon in nature and are typically constructed from oximes through the oxidative decarboxylation of amino acid substrates or from the derivatization of carboxylic acids.
S. Adak, N. Ye, L. Calderone, Meng Duan, Wilson Lubeck, Rebecca J B Schäfer, A. Lukowski, K. Houk, M. Pandelia, Catherine L. Drennan, Bradley S. Moore   +10 more
semanticscholar   +1 more source

Structural insights into 2-oxindole-forming monooxygenase MarE: Divergent architecture and substrate positioning versus tryptophan dioxygenases

Journal of Biological Chemistry
MarE, a heme-dependent enzyme, catalyzes a unique 2-oxindole-forming monooxygenation reaction from tryptophan metabolites. To elucidate its enzyme-substrate interaction mode, we present the first X-ray crystal structures of MarE in complex with its prime
Inchul Shin, R.C.D. Nguyen, S. R. Montoya, Aimin Liu   +3 more
semanticscholar   +1 more source

NMDA receptor activation mediates lipopolysaccharide-induced depressive-like behavior

European Journal of Psychotraumatology, 2012
Background : Inflammation associated with cancer and induced by cancer therapy is associated with clinical signs of sickness behavior that can culminate in the development of symptoms of depression. Intraperitoneal administration of lipopolysaccharide to
Adam Walker, Robin Smith, Bret Beenders, Keith Kelley, Robert Dantzer   +4 more
doaj   +1 more source

Purification and Properties of Rat Liver Tryptophan Oxygenase

Journal of Biological Chemistry, 1972
Abstract Tryptophan oxygenase has been purified from livers of glucocorticoid and l-tryptophan-treated rats. Homogeneity of the enzyme was established by polyacrylamide electrophoresis, sedimentation experiments, and immunodiffusion. Amino acid analyses reveal 6 residues of cysteine per enzyme molecule.
G, Schutz, P, Feigelson
openaire   +2 more sources

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

Renoprotection by 5-Methoxytryptophan in Kidney Disease

Biomolecules
Kidney disease, be it acute or chronic, has a complex pathology and is a significant human health problem. Increasing interest has been focused on exploring therapeutic targets that can be used to safeguard kidney function under a variety of detrimental ...
Jonah P. Gutierrez, Tram N. Diep, Shaona Niu, Liang-Jun Yan   +3 more
doaj   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Inhibition of tryptophan oxygenase in rat liver by steroid hormones [PDF]

Biochemical Journal, 1970
Pregnant women and normal humans treated with estrogens show evidence of increased conversion of L-tryptophan into nicotinic acid ribonucleotide. Increased activity of liver tryptophan oxygenase caused by the action of estrogens or elevated corticosteroid concentration is thought to be the cause. Progesterone caused a decrease in tryptophan oxygenase
I P, Braidman, D P, Rose
openaire   +2 more sources

Protective effects of extracellular vesicle‐like nanoparticles derived from Cannabis sativa adventitious roots against UVB‐induced damage in human keratinocytes

International Journal of Cosmetic Science, EarlyView.
Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak, Su Hyun Park, Young Bae Ryu, Cha Young Kim, Jae Cheol Jeong, Woo Sik Kim   +5 more
wiley   +1 more source