Results 21 to 30 of about 87,880 (172)

Tryptophan metabolism in tsetse flies and the consequences of its derangement

Memorias do Instituto Oswaldo Cruz, 1987
Literature comparing salmon and wild type Glossina morsitans morsitans and that comparing tan and wild type Glossina palpalis palpalis is reviewed. New information is presented on behaviour and biochemistry of salmon and wild type G. m. morsitans.
R. H. Gooding, B. M. Rolseth
doaj   +1 more source

The Prematurely Evoked Synthesis of Liver Tryptophan Oxygenase [PDF]

Proceedings of the National Academy of Sciences, 1971
Livers of normal rats are devoid of catalytically or immunochemically reactive tryptophan oxygenase (EC 1.13.1.12) up to the 10th postnatal day; the enzyme reaches adult concentrations on about the twentieth day. Premature tryptophan oxygenase synthesis can be evoked in 4-day-old rats: if an injection of glucocorticoid is followed, a day later, by an ...
O, Greengard, H K, Dewey
openaire   +2 more sources

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts

Journal of Inflammation, 2011
Background The kynurenine pathway (KP) is the main route of tryptophan degradation in the human body and generates several neuroactive and immunomodulatory metabolites.
Kegel Magdalena, Kocki Tomasz, Urbanska Ewa M, Owe-Larsson Björn, Mann Amandeep, Johansson Anne-Sofie, Asp Linnéa, Engberg Göran, Lundkvist Gabriella BS, Karlsson Håkan   +9 more
doaj   +1 more source

Regulatory Properties of Hepatic Tryptophan Oxygenase

Journal of Biological Chemistry, 1972
Abstract The kinetic properties of highly purified hepatic l-tryptophan oxygenase have been studied at different hydrogen ion concentrations in the absence and presence of dl-α-methyltryptophan and 3-hydroxyanthranilic acid. At pH 8.0 plots of velocity versus l-tryptophan concentrations indicate classical hyperbolic Michaelis-Menten kinetics, whereas ...
G, Schutz, E, Chow, P, Feigelson
openaire   +2 more sources

Key Enzymes and Proteins of Crop Insects as Candidate for RNAi Based Gene Silencing

Frontiers in Physiology, 2015
RNA interference (RNAi) is a mechanism of homology dependent gene silencing present in plants and animals. It operates through 21-24 nucleotides small RNAs which are processed through a set of core enzymatic machinery that involves Dicer and Argonaute ...
Vijaya Sudhakara Rao K, Renuka eP, Sheshu Madhav M, Satendra Kumar Mangrauthia   +3 more
doaj   +1 more source

Inactivation of Tryptophan Oxygenase in Vivo and in Vitro

Journal of Biological Chemistry, 1972
Abstract The loss of tryptophan oxygenase from rat livers after induction by hydrocortisone treatment was studied in living rats, isolated perfused livers, liver slices and cell-free preparations of these livers. Measurements of the enzyme by its activity and as an antigen were parallel except for apparently nonspecific inactivations in some ...
J B, Li, W E, Knox
openaire   +2 more sources

Indoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia

Frontiers in Pharmacology, 2017
Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan which accumulates in patients with impaired renal function, such as chronic kidney disease (CKD).
Simona Adesso, Simona Adesso, Tim Magnus, Salvatore Cuzzocrea, Michela Campolo, Björn Rissiek, Orlando Paciello, Giuseppina Autore, Aldo Pinto, Stefania Marzocco   +9 more
doaj   +1 more source

Genes and pathways for CO₂ fixation in the obligate, chemolithoautotrophic acidophile, Acidithiobacillus ferrooxidans, Carbon fixation in A. ferrooxidans

BMC Microbiology, 2010
Background Acidithiobacillus ferrooxidans is chemolithoautotrophic γ-proteobacterium that thrives at extremely low pH (pH 1-2). Although a substantial amount of information is available regarding CO2 uptake and fixation in a variety of facultative ...
Esparza Mario, Cárdenas Juan, Bowien Botho, Jedlicki Eugenia, Holmes David S   +4 more
doaj   +1 more source

Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (The Ludwigshafen risk and cardiovascular health study) [PDF]

, 2009
Background Heme oxygenase-1 is an inducible cytoprotective enzyme which handles oxidative stress by generating anti-oxidant bilirubin and vasodilating carbon monoxide.
Hoffmann Michael M, Hoffmann, Michael Marcus, März Winfried, Boehm Bernhard O, Wellnitz Britta, Karl Winkler, Bernhard O Boehm, Bernhard R Winkelmann, März, Winfried, Winkelmann Bernhard R, Winkler Karl, Hoffmann, Michael M., Seelhorst Ursula, Ursula Seelhorst, Seelhorst, Ursula, Britta Wellnitz, Böhm, Bernhard O., Böhm, Bernhard Otto, Michael M Hoffmann, Lüblinghoff Nicola, Lüblinghoff, Nicola, Winkelmann, Bernhard Rudolf, Winfried März, Winkler, Karl, Nicola Lüblinghoff, Winkelmann, Bernhard R., Wellnitz, Britta   +26 more
core   +2 more sources

Sirtuin 2 regulates neutrophil functions through NAD+ synthesis pathway in virus infection

iScience
Summary: Neutrophils play an important role in antiviral immunity, but the underlying mechanisms remain unclear. Here, we found that SIRT2 deficiency inhibited the infiltration of neutrophils, as well as the secretion of inflammatory cytokines and the ...
Zhiyuan Zhang, Qiuli Yang, Yingjie Dong, Likun Wang, Ruiying Niu, Jingxuan Xia, Yujing Bi, Guangwei Liu   +7 more
doaj   +1 more source