Renoprotection by 5-Methoxytryptophan in Kidney Disease [PDF]
BiomoleculesKidney disease, be it acute or chronic, has a complex pathology and is a significant human health problem. Increasing interest has been focused on exploring therapeutic targets that can be used to safeguard kidney function under a variety of detrimental ...
Jonah P. Gutierrez +3 more
doaj +2 more sources
Microbiome-Derived Tryptophan Metabolites Regulate AhR Signaling to Restore Epithelial Barrier Integrity in Inflammatory Bowel Disease. [PDF]
MicrobiologyopenThe graphical abstract illustrates how microbiome‐derived indoles activate the aryl hydrocarbon receptor to restore the intestinal barrier. The picture contrasts the “leaky gut” state with the restored homeostasis achieved through AMPK, Nrf2, and IL‐22 signaling.
Mahdiabadi MA, Moghaddam A, Erfanian N.
europepmc +2 more sources
RNAi-induced silencing of embryonic tryptophan oxygenase in the Pyralid moth, Plodia interpunctella
Journal of Insect Science, 2004 Gene silencing through the introduction of double-stranded RNA (RNA interference, RNAi) provides a powerful tool for the elucidation of gene function in many systems, including those where genomics and proteomics are incomplete.
Jeffrey A. Fabrick +2 more
doaj +1 more source
Validation of a model of regulation in the tryptophan operon against multiple experiment data using global optimisation [PDF]
, 2009 This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the ...
Postlethwaite, I. +4 more
core +8 more sources
Tryptophan research in panic disorder. [PDF]
, 2008 09.02.15 KB. Ok to add published version to spiral, OA paperA considerable body of evidence suggests the involvement of serotonin neurotransmission in the pathogenesis of panic disorder.
Shlik, J, Maron, E, Nutt, DJ
core +7 more sources
Novel immune cell infiltration-related biomarkers in atherosclerosis diagnosis [PDF]
PeerJ, 2023 Background Immune cell infiltration (ICI) has a close relationship with the progression of atherosclerosis (AS). Therefore, the current study was aimed to explore the role of genes related to ICI and to investigate potential mechanisms in AS.
Ruoyu Dong +5 more
doaj +2 more sources
Detoxification of Indole by an Indole-Induced Flavoprotein Oxygenase from Acinetobacter baumannii. [PDF]
PLoS ONE, 2015 Indole, a derivative of the amino acid tryptophan, is a toxic signaling molecule, which can inhibit bacterial growth. To overcome indole-induced toxicity, many bacteria have developed enzymatic defense systems to convert indole to non-toxic, water ...
Guang-Huey Lin +2 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Tuberculosis (TB) caused by the complex Mycobacterium tuberculosis (Mtb) is the main cause of death by a single bacterial agent. Last year, TB was the second leading infectious killer after SARS-CoV-2.
Vasti Lozano-Ordaz +7 more
doaj +1 more source
HEME OXYGENASE-1 UPREGULATED BY MELATONIN: POTENTIAL PROTECTION AGAINST BURN-INDUCED OXIDATIVE GASTRIC MUCOSAL INJURY. [PDF]
Journal of IMAB, 2015 Melatonin is indoleamine hormone derived from L-tryptophan. Due to its lipophilic nature, it is accessible to every cell. Melatonin has immunomodulatory and antioxidant activities thus protecting tissue injury.
Minka Hristova +2 more
doaj +1 more source
PyrH and PrnB crystal structures [PDF]
, 2006 Determination of the three-dimensional structure of enzymes at atomic resolution is a key prerequisite for elucidation of molecular mechanisms of catalysis and catalysis mechanism prediction.
De Laurentis, Walter
core +2 more sources