Detoxification of Indole by an Indole-Induced Flavoprotein Oxygenase from Acinetobacter baumannii. [PDF]
PLoS ONE, 2015 Indole, a derivative of the amino acid tryptophan, is a toxic signaling molecule, which can inhibit bacterial growth. To overcome indole-induced toxicity, many bacteria have developed enzymatic defense systems to convert indole to non-toxic, water ...
Guang-Huey Lin +2 more
doaj +2 more sources
Tryptophan metabolism in tsetse flies and the consequences of its derangement
Memorias do Instituto Oswaldo Cruz, 1987 Literature comparing salmon and wild type Glossina morsitans morsitans and that comparing tan and wild type Glossina palpalis palpalis is reviewed. New information is presented on behaviour and biochemistry of salmon and wild type G. m. morsitans.
R. H. Gooding, B. M. Rolseth
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Renoprotection by 5-Methoxytryptophan in Kidney Disease [PDF]
BiomoleculesKidney disease, be it acute or chronic, has a complex pathology and is a significant human health problem. Increasing interest has been focused on exploring therapeutic targets that can be used to safeguard kidney function under a variety of detrimental ...
Jonah P. Gutierrez +3 more
doaj +2 more sources
RNAi-induced silencing of embryonic tryptophan oxygenase in the Pyralid moth, Plodia interpunctella
Journal of Insect Science, 2004 Gene silencing through the introduction of double-stranded RNA (RNA interference, RNAi) provides a powerful tool for the elucidation of gene function in many systems, including those where genomics and proteomics are incomplete.
Jeffrey A. Fabrick +2 more
doaj +1 more source
HEME OXYGENASE-1 UPREGULATED BY MELATONIN: POTENTIAL PROTECTION AGAINST BURN-INDUCED OXIDATIVE GASTRIC MUCOSAL INJURY. [PDF]
Journal of IMAB, 2015 Melatonin is indoleamine hormone derived from L-tryptophan. Due to its lipophilic nature, it is accessible to every cell. Melatonin has immunomodulatory and antioxidant activities thus protecting tissue injury.
Minka Hristova +2 more
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Degradation of Tryptophan Oxygenase in Vivo and in Vitro. [PDF]
, 1972 The loss of tryptophan oxygenase from rat livers after induction by hydrocortisone treatment was studied in living rats, isolated perfused livers, liver slices and cell-free preparations of these livers.
Li, J B, Knox, W E
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Sirtuin 2 regulates neutrophil functions through NAD+ synthesis pathway in virus infection
iScienceSummary: Neutrophils play an important role in antiviral immunity, but the underlying mechanisms remain unclear. Here, we found that SIRT2 deficiency inhibited the infiltration of neutrophils, as well as the secretion of inflammatory cytokines and the ...
Zhiyuan Zhang +7 more
doaj +2 more sources
Mechanisms of Development, 1994 peer reviewedExpression of the gene coding for tryptophan oxygenase (TO) is switched on in rat liver about two weeks after birth. We identified two clusters of DNaseI hypersensitive (HS) sites in the TO gene upstream region; one near the promoter, the ...
Marc Müller +2 more
exaly +2 more sources
Single-Enzyme Conversion of Tryptophan to Skatole and Cyanide Expands the Mechanistic Competence of Diiron Oxidases. [PDF]
J Am Chem SocSkatole is a pungent heterocyclic compound derived from the essential amino acid l-tryptophan by bacteria in the mammalian digestive tract. The four-step anaerobic conversion of tryptophan to skatole is well-established; though, to date, no aerobic ...
Adak S +4 more
europepmc +2 more sources
Tryptophan oxygenase activity and sensitivity to tryptophan in adrenalectomized mice
, 1970 Thesis (M.S.)--Michigan State University.
Beine, Melba Jean
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