Results 41 to 50 of about 164,861 (180)

Multi‐Omics Analysis Identifies Tryptophan Metabolism and Glycolysis as Potential Pathways Involved in the Protective Effects of Tormentic Acid Against Metabolic Associated Fatty Liver Disease

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
TA alleviates MCD diet‐induced MAFLD, and this effect is associated with alterations in tryptophan metabolism and glycolysis. ABSTRACT Metabolic associated fatty liver disease (MAFLD) has high morbidity and tragically lacks effective therapeutic remedies.
Yuanyuan Wei, Dingyi Wei, Jingyang Lu, Lulin Wei, Weijia Lin, Jinbin Wei, Xiao Ma   +6 more
wiley   +1 more source

The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis

Phytotherapy Research, Volume 40, Issue 8, Page 5071-5089, August 2026.
ABSTRACT The gut‐lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeostasis, collectively influencing disease susceptibility and progression.
Jian Kang, YongJun Du, Yanmei Hou, Liangliang Hao, Zhen Chen, Haoyang Xie, Chuantao Zhang, Lei Li   +7 more
wiley   +1 more source

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, Volume 22, Issue 43, 3 August 2026.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, Volume 293, Issue 15, Page 4533-4553, August 2026.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Beneath the Bark: Molecular Determinants of Adaptation and Infection in Bacterial Pathogens of Woody Hosts

Molecular Plant Pathology, Volume 27, Issue 8, August 2026.
Bacterial pathogens colonise woody hosts by integrating metabolic adaptation, effector‐mediated immune suppression, cell wall remodelling and EPS‐ and toxin‐supported persistence. ABSTRACT Bacterial pathogens of woody plants represent a pervasive yet underexplored threat to global agriculture and forestry, causing devastating diseases in fruit trees ...
Antonio Arroyo‐Mateo, Jesús Murillo, Luis Rodríguez‐Moreno, Cayo Ramos   +3 more
wiley   +1 more source

Activation of liver tryptophan oxygenase by adenosine 3',5'-phosphate and by other purine derivatives.

Journal of Biological Chemistry, 1968
The latent form of tryptophan oxygenase (EC 1.13.1.12), which can be demonstrated in the soluble supernatant of liver through the addition of adenosine 3',5'-phosphate or other purine derivatives, differs from the form which is activated by the addition ...
F. Chytil
semanticscholar   +1 more source

Transcriptome and Hormone Regulations Shape Drought Stress‐Dependent Fusarium Head Blight Susceptibility in Different Barley Genotypes

Plant, Cell &Environment, Volume 49, Issue 8, Page 5738-5755, August 2026.
ABSTRACT Little is known about regulatory mechanisms that crop plants use to respond to combinations of abiotic and biotic stress. We analysed four barley genotypes under simultaneous Fusarium culmorum infection and drought stress by phenotyping for Fusarium Head Blight (FHB) disease, drought stress responses, hormone profiling and transcriptome ...
Felix Hoheneder, Christina Elisabeth Steidele, Michael Gigl, Corinna Dawid, Ralph Hückelhoven   +4 more
wiley   +1 more source

Food and Medicinal Homologous Substances in Sleep Disorders Improvement: Current Advances and Future Perspectives

Food Frontiers, Volume 7, Issue 4, July 2026.
The schematic diagram illustrating the improvement mechanisms of six typical FMH substances and their main active ingredients in different sleep disorders. ABSTRACT Sleep integrates many brain and peripheral processes, profoundly influencing well‐being.
Wenjing Wen, Qili Li, Chenghao Lv, Jing Wen, Yihan Zhang, Yuhang Yi, Tao Li, Fang Wang, Yibo Luo, Si Qin   +9 more
wiley   +1 more source

Effects of Se Application on Antioxidants and L‐DOPA Contents of Plant Parts in Faba Bean Cultivars (Vicia faba L.) in Salt Conditions

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Selenium‐Mediated Resilience in Vicia faba: The accumulation of secondary metabolites in Vicia faba L. represents a sophisticated and dynamic adaptive strategy in response to environmental perturbations. Our findings demonstrate that Selenium (Se) functions as a potent metabolic elicitor rather than a mere micronutrient, significantly modulating the ...
Nurdoğan Topal, Ayşe Topuz
wiley   +1 more source