Results 51 to 60 of about 7,892 (182)

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Altered Tryptophan Catabolism in Placentas From Women With Pre-eclampsia

, 2019
Background: The kynurenine pathway enzymes, breaking down tryptophan, are abundant in placental tissue. These metabolites are involved in immunoregulatory mechanisms, although the role of this pathway in pre-eclampsia (PE) has only begun to be ...
Sarah A Keaton, Patrick Heilman, Grit, Jamie, Karen Racicot, Maya Jälmby, Zachary Madaj, Jälmby, Maya, Asgerally Fazleabas, Miller, Emily S., Brundin, Lena, Keaton, Sarah A., Racicot, Karen, Madaj, Zachary, Emily S Miller, Stefan R Hansson, Grigoros Kalapotharakos, Fazleabas, Asgerally, Kalapotharakos, Grigoros, Lena Brundin, Hansson, Stefan R., Stanislaw Krzyzanowski, Bryleva, Elena Y., Jamie Grit, Elena Y Bryleva, Heilman, Patrick, Krzyzanowski, Stanislaw   +25 more
core   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

SlTDC modulates photosynthesis of senescent leaves in tomato

Horticulture Advances
Melatonin (MT) is a key regulator in plants’ response to leaf senescence induced by aging or various abiotic stresses. Here, we demonstrated that darkness and leaf aging enhance endogenous MT levels by upregulating key genes involved in MT synthesis ...
Yanan Wang, Tongtong Jing, Xutao Liu, Xizhen Ai, Huangai Bi   +4 more
doaj   +1 more source

Identification of the region of glucocorticoid-receptor complex binding in the structural part of rat tryptophan oxygenase gene

, 1990
Исследовали связывание глюкокортикоидного рецептора с фрагментами ДНК гена триптофаноксигеназы (ТО) крысы с помощью методов задержки комплексов белок — ДНК на нитроцеллюлозных фильтрах и осаждения моноклональными антителами к глюкокортикоидному рецептору.
Меркулова, Т.И., Меркулов, В.М.   +1 more
core   +1 more source

Protective effects of extracellular vesicle‐like nanoparticles derived from Cannabis sativa adventitious roots against UVB‐induced damage in human keratinocytes

International Journal of Cosmetic Science, EarlyView.
Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak, Su Hyun Park, Young Bae Ryu, Cha Young Kim, Jae Cheol Jeong, Woo Sik Kim   +5 more
wiley   +1 more source

Transcriptome and Hormone Regulations Shape Drought Stress‐Dependent Fusarium Head Blight Susceptibility in Different Barley Genotypes

Plant, Cell &Environment, EarlyView.
ABSTRACT Little is known about regulatory mechanisms that crop plants use to respond to combinations of abiotic and biotic stress. We analysed four barley genotypes under simultaneous Fusarium culmorum infection and drought stress by phenotyping for Fusarium Head Blight (FHB) disease, drought stress responses, hormone profiling and transcriptome ...
Felix Hoheneder, Christina Elisabeth Steidele, Michael Gigl, Corinna Dawid, Ralph Hückelhoven   +4 more
wiley   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

The Great Bustard (Otis tarda) and Common Crane (Grus grus) Utilize Food Resources via Gut Microbiota Remodeling During Wintering in the Yellow River Wetlands in Ordos City, Inner Mongolia, China

Ecology and Evolution, Volume 16, Issue 6, June 2026.
This study detected the diet and gut microbiota of great bustards and common cranes in the wintering duration in the Yellow River Wetlands of Inner Mongolia using high‐throughput sequencing technology. This study indirectly indicated that great bustards and common cranes are well‐adapted to the environment of the Yellow River Wetlands during the ...
Li Gao, Haitao Fang, Hongda Pei, Junlan Li, Li Liu   +4 more
wiley   +1 more source

Postbiotic Supernatants From Psychobiotic Strains Modulate Antioxidant and Serotonergic Responses

eFood, Volume 7, Issue 3, June 2026.
Cell‐free postbiotic supernatants obtained from psychobiotic strains exhibit strain‐dependent antioxidant and serotonergic effects. SCFA‐rich metabolites enhance antioxidant protection and modulate serotonin release in enterochromaffin cells, supporting their potential as functional ingredients for gut and brain health.
Cocean Ana‐Maria, Zorita Diaconeasa, Calina Ciont, Razvan Odocheanu, Alexandra Machitescu, Floricuta Ranga, Dan Cristian Vodnar   +6 more
wiley   +1 more source