Results 71 to 80 of about 7,892 (182)

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan, Katie Powell, Russ Chess‐Williams, Catherine McDermott   +3 more
wiley   +1 more source

The Endogenous Tryptophan Metabolite and NAD(+) Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress [PDF]

, 2013
Quinolinic acid is a product of tryptophan degradation and may serve as a precursor for NAD(+), an important enzymatic cofactor for enzymes such as the DNA repair protein PARP.
Bode, H., Ahrendt, T., Opitz, C., Sahm, F., Radlwimmer, B., Adams, S., Wick, W., von Deimling, A., Platten, M., Oezen, I., Guillemin, G.   +10 more
core   +1 more source

Identification of 2‐Substituted‐3‐Hydroxy‐2,3‐Dihydroquinazolin‐4(1H) Ones as Cell‐Active Inhibitors of KDM4A Lysine Demethylase

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A novel 3‐hydroxy‐2,3‐dihydroquinazolinone scaffold is identified as a cell‐active KDM4A inhibitor through an orthogonal screening cascade minimizing assay interference. Integrated biochemical, biophysical, and proteomic validation reveals compound 6i as a bona fide binder that increases H3K9 methylation in cells, highlighting both a promising ...
Alessandra Feoli, Amodio Luca Balzano, Ida Pacilio, Alessandra Cipriano, Roman Belle, Giacomo Pepe, Manuela Giovanna Basilicata, Pietro Campiglia, Fabrizio Micheli, Akane Kawamura, Ciro Milite, Sabrina Castellano, Axel Imhof, Gianluca Sbardella   +13 more
wiley   +1 more source

Glucocorticoid receptor and Tryptophan oxygenase activity in streptozotocin treated rats.

, 1997
The goal of this study was to examine the possible effects of the insulin on the functional properties of the glucocorticoid receptor (GR), in the rat liver, as well as its equilibrium binding constant (Kd) and number of binding sites (q), in order to ...
Kanazir, DT, Kanazir, Dušan T., Ribarac-Stepić, Nevena B., Isenović, Esma R., Korićanac, Goran   +4 more
core  

Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.

, 2016
Changes in metabolite levels of the kynurenine pathway have been observed in patients with CKD, suggesting involvement of this pathway in disease pathogenesis. Our recent genetic analysis in the mouse identified the kynurenine 3-mono-oxygenase (KMO) gene
Staggs, Lynne, Korstanje, Ron, Sheehan, Susan, Holly Savage, Hermann Haller, Lynne Staggs, Roberts, Ian S D, Ian S.D. Roberts, Konstantin Deutsch, Savage, Holly S, Haller, Hermann, Nils Hanke, Schiffer, Mario, Jan H. Bräsen, Deutsch, Konstantin, Hanke, Nils, Susan Sheehan, Schroder, Patricia, Bräsen, Jan H, Ron Korstanje, Patricia Bolanos-Palmieri, Patricia Schroder, Mario Schiffer, Bolanos-Palmieri, Patricia   +23 more
core   +1 more source

Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]

, 1987
Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Strähle, Uwe, Boshart, Michael, Schmid, Wolfgang, Miksicek, Richard, Jansen, Hans-Michael, Gloss, Bernd, Schlitz, Günther, Stewart, Francis   +7 more
core   +1 more source

Studies on the Interaction of Carbon Monoxide with Tryptophan Oxygenase of Pseudomonas

Journal of Biological Chemistry, 1968
Abstract 1. The inhibition of Pseudomonas tryptophan oxygenase by carbon monoxide is competitive with respect to oxygen and is photodissociable. The photochemical action spectrum, with a maximum at 421 mµ, is identical with the Soret absorption spectrum of the tryptophan-carboxyferroprotoporphyrin-enzyme complex.
H, Maeno, P, Feigelson
openaire   +2 more sources

Studies on In Vitro Induction of Terminal Differentiation in Immature Hepatocytes and Expression of Tryptophan Oxygenase

, 1987
Tryptophan 2, 3-dioxygenase（TO, EC 1.13. 11. 11.）is a typical liver specific enzyme that appears in human liver postnatally and reaches to adult level 9 months after birth.
長尾, 雅悦
core   +1 more source