Results 51 to 60 of about 1,087,731 (295)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Exploring the interplay between running exercises, microbial diversity, and tryptophan metabolism along the microbiota-gut-brain axis

Frontiers in Microbiology
The emergent recognition of the gut-brain axis connection has shed light on the role of the microbiota in modulating the gut-brain axis’s functions. Several microbial metabolites, such as serotonin, kynurenine, tryptamine, indole, and their derivatives ...
Alejandra Vazquez-Medina, Nicole Rodriguez-Trujillo, Kiara Ayuso-Rodriguez, Fabiana Marini-Martinez, Roberto Angeli-Morales, Gerardo Caussade-Silvestrini, Filipa Godoy-Vitorino, Nataliya Chorna   +7 more
doaj   +1 more source

Tryptophan metabolism through the kynurenine pathway.

, 2018
Tryptophan metabolism proceeds through kynurenine in multiple branches, which includes the formation of KYNA by the KAT enzymes.
Gayan S. Jayawickrama (5136161), Alireza Nematollahi (3564125), Guanchen Sun (5136164), William Bret Church (5136158)   +3 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Tryptophan Metabolism in Allergic Disorders [PDF]

International Archives of Allergy and Immunology, 2016
Allergic diseases such as asthma and rhinitis, as well the early phase of atopic dermatitis, are characterized by a Th2-skewed immune environment. Th2-type cytokines are upregulated in allergic inflammation, whereas there is downregulation of the Th1-type immune response and related cytokines, such as interferon-γ (IFN-γ).
Johanna M, Gostner, Katrin, Becker, Heinz, Kofler, Barbara, Strasser, Dietmar, Fuchs   +4 more
openaire   +2 more sources

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis

Biology Direct
Background Precision oncology’s implementation in clinical practice faces significant constraints due to the inadequacies in tools for detailed patient stratification and personalized treatment methodologies.
Fan Li, Haiyi Hu, Liyang Li, Lifeng Ding, Zeyi Lu, Xudong Mao, Ruyue Wang, Wenqin Luo, Yudong Lin, Yang Li, Xianjiong Chen, Ziwei Zhu, Yi Lu, Chenghao Zhou, Mingchao Wang, Liqun Xia, Gonghui Li, Lei Gao   +17 more
doaj   +1 more source

ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency

Cell Death Discovery, 2021
Tryptophan metabolism is an essential regulator of tumor immune evasion. However, the effect of tryptophan metabolism on cancer cells remains largely unknown.
Mingqing Cui, Dan Liu, Wujun Xiong, Yugang Wang, Jun Mi   +4 more
doaj   +1 more source

Tryptophan metabolism in vitamin B6-deficient mice [PDF]

, 1990
Vitamin B6 deficiency was induced in mice by maintenance for 4 weeks on a vitamin B6-free diet. Tryptophan metabolism was assessed by determining the urinary excretion of tryptophan metabolites, the metabolism of [14C]tryptophan in vivo and the formation
Bender, DA, Njagi, EN, Danielian, PS
core  

Tryptophan metabolism along the kynurenine pathway in rats

, 2003
Enzyme activities along the kynurenine pathway, liver tryptophan 2,3-dioxygenase, small intestine indole 2,3-dioxygenase, liver and kidney kynurenine 3-monooxygenase, kynureninase, kynurenine-oxoglutarate transaminase, 3-hydroxyanthranilate 3,4 ...
ALLEGRI, GRAZIELLA, Raniero Rocchi, COSTA, CARLO VIRGILIO LUIGI, Eugenio Ragazzi, Carlo V. L. Costa, Laura Caparrotta, ROCCHI R., Silvia Vanin, Monica Biasiolo, BIASIOLO M., BERTAZZO, ANTONELLA, VANIN S., RAGAZZI, EUGENIO, Graziella Allegri, CAPARROTTA, LAURA, Antonella Bertazzo   +15 more
core   +1 more source