Results 71 to 80 of about 1,036,536 (283)

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Seasonal Plasticity in Tryptophan Metabolism Provides New Insights Into Physiological Adaptation in Snake Hibernation

Ecology and Evolution
Hibernation is a common behavioral strategy for snakes to cope with extreme environments. This phenomenon has raised important scientific questions regarding its physiological adaptation mechanisms. Although tryptophan and its metabolites have been widel
Yuting Wei, Zexiu Zhang, Xiaohong Lin, Gangning Wei, Pengyue Zhang, Huirong Mao, Biao Chen, Jianhao Ji, Yunlin Zheng, Zhiyi Luo, Xiaolong Hu   +10 more
doaj   +1 more source

Tryptophan-kynurenine pathway: a possible new mechanism for the prevention and treatment of reproductive system-related diseases [PDF]

PeerJ
Tryptophan (Trp) is one of the essential amino acids, and its metabolic pathway is essential for the maintenance of normal human physiological activities.
Zhongkai Ou, Aixia Xu, Hua Su, Yiting Liu, Jia Li   +4 more
doaj   +2 more sources

Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model

Human Vaccines & Immunotherapeutics, 2020
In allergen-specific immunotherapy for asthma, antigens attached to dendritic cells increase the tryptophan metabolism in these cells and alter the Th17/Treg balance in the airways.
Qi Hu, Ling Jin, Jing Zeng, Jinyu Wang, Shimin Zhong, Wenting Fan, Wei Liao   +6 more
doaj   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Identification and validation of tryptophan-related gene signatures to predict prognosis and immunotherapy response in lung adenocarcinoma reveals a critical role for PTTG1

Frontiers in Immunology
IntroductionTryptophan metabolism is strongly associated with immunosuppression and may influence lung adenocarcinoma prognosis as well as tumor microenvironment alterations.MethodsSequencing datasets were obtained from The Cancer Genome Atlas (TCGA) and
Ziqiang Wang, Ziqiang Wang, Jing Zhang, Chao Zuo, Huili Chen, Luyao Wang, Yiluo Xie, Hongyu Ma, Shengping Min, Xiaojing Wang, Chaoqun Lian   +10 more
doaj   +1 more source

Cancer immunotherapy by targeting IDO1/TDO and their downstream effectors

Frontiers in Immunology, 2015
The tryptophan to kynurenine metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes ...
Michael ePlatten, Nikolaus evon Knebel Doeberitz, Iris eOezen, Wolfgang eWick, Katharina eOchs   +4 more
doaj   +1 more source

Low Levels of Serum Tryptophan Underlie Skeletal Muscle Atrophy

, 2020
Sarcopenia is a poor prognosis factor in some cancer patients, but little is known about the mechanisms by which malignant tumors cause skeletal muscle atrophy.
Makoto Shiraki, Kimihiro Yamaguchi, Taku Mizutani, Hisashi Tsurumi, Nobuhiko Nakamura, Nobuhiro Kanemura, Junichi Kitagawa, Yuto Kaneda, Takuro Matsumoto, Masahito Shimizu, Soranobu Ninomiya, Hiroshi Nakamura, Takeshi Hara   +12 more
core   +1 more source

Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function

, 2022
The metabolism of dietary tryptophan occurs locally in the gut primarily via host enzymes, with similar to 5% metabolized by gut microbes. Three major tryptophan metabolic pathways are serotonin (beyond the scope of this review), indole, kynurenine and ...
Hornby, Pamela J., Hyland, Niall P., Cavanaugh, Cassandre R.   +2 more
core   +1 more source

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source