Results 61 to 70 of about 10,379 (248)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Kynurenine Pathway: a Proposed Mechanism Linking Diabetes and Periodontal Disease in Diabetic Patients

Dental Hypotheses, 2011
Introduction: Diabetes mellitus is a metabolic disease characte-rized by dysregulation of carbohydrate, protein and lipid metabolism. Diabetes could result, in part, in activation of tryptophan metabolism.
Rishabh Kapila, KS Nagesh, Asha R. Iyengar, Subash BV. Adiga   +3 more
doaj  

Diabetes and Tryptophan Metabolism

, 2015
Tryptophan, an essential amino acid, can be metabolized to several kinds of physiologically active metabolites. Accumulating data indicate that an altered metabolism of tryptophan and its active metabolites have important roles for the pathogenesis and ...
Tomris Erbas, ÜNLÜTÜRK, UĞUR, Erbas, Tomris, Ugur Unluturk   +3 more
core   +1 more source

Low Levels of Serum Tryptophan Underlie Skeletal Muscle Atrophy

, 2020
Sarcopenia is a poor prognosis factor in some cancer patients, but little is known about the mechanisms by which malignant tumors cause skeletal muscle atrophy.
Makoto Shiraki, Kimihiro Yamaguchi, Taku Mizutani, Hisashi Tsurumi, Nobuhiko Nakamura, Nobuhiro Kanemura, Junichi Kitagawa, Yuto Kaneda, Takuro Matsumoto, Masahito Shimizu, Soranobu Ninomiya, Hiroshi Nakamura, Takeshi Hara   +12 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis

Journal of Translational Medicine
Background Ulcerative colitis (UC) is a persistent inflammatory bowels disease (IBD) characterized by immune response dysregulation and metabolic disruptions.
Guorong Chen, Hongying Qi, Li Jiang, Shijie Sun, Junhai Zhang, Jiali Yu, Fang Liu, Yanli Zhang, Shiyu Du   +8 more
doaj   +1 more source

Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses

Plant Communications
Plants are frequently threatened by diverse stresses that severly impact their health and constrain crop productivity worldwide. Metabolic regulation serves as an important strategy for enhancing plant stress tolerance.
Shuang Wang, Xia Zhang, Dao-Hong Gong, Qiu-Qian Huang, W.M.W.W. Kandegama, Milen I. Georgiev, Yang-Yang Gao, Pan Liao, Ge-Fei Hao   +8 more
doaj   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Tryptophan-kynurenine pathway: a possible new mechanism for the prevention and treatment of reproductive system-related diseases [PDF]

PeerJ
Tryptophan (Trp) is one of the essential amino acids, and its metabolic pathway is essential for the maintenance of normal human physiological activities.
Zhongkai Ou, Aixia Xu, Hua Su, Yiting Liu, Jia Li   +4 more
doaj   +2 more sources

Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model

Human Vaccines & Immunotherapeutics, 2020
In allergen-specific immunotherapy for asthma, antigens attached to dendritic cells increase the tryptophan metabolism in these cells and alter the Th17/Treg balance in the airways.
Qi Hu, Ling Jin, Jing Zeng, Jinyu Wang, Shimin Zhong, Wenting Fan, Wei Liao   +6 more
doaj   +1 more source