Results 91 to 100 of about 1,087,731 (295)

Tryptophan metabolism reprogramming regulates Th1/Th2 immune balance and inhibits mast cell activation

Amino Acids
Asthma is characterized by chronic airway inflammation and an imbalanced Th1/Th2 response. Although tryptophan metabolism has been implicated in immune regulation, its direct influence on Th1/Th2 differentiation and mast-cell activation remains ...
Dongsheng Huang, Dongxuan Huang, Lianhui Su, Chaowen He, Xiaopeng Zhang, Jianfeng Peng, Lumei Fan, Yahui Cao, Licheng Chen, Huifen Tong   +9 more
doaj   +1 more source

Sleep, Tryptophan Metabolism, and Breast Cancer: Implications for Public Health Nutrition

World Nutrition
Breast cancer remains the most frequently diagnosed cancer among women worldwide and represents a major public health challenge. Sleep disturbances are highly prevalent in women with breast cancer and have been associated with impaired quality of life ...
Nádia Raci Marques Pereira, Isabela Antunes Ishikura, Sergio Tufik, Helena Hachul   +3 more
doaj   +1 more source

Tryptophan metabolism in the central nervous system: medical implications [PDF]

, 2006
The metabolism of the amino acid L-tryptophan is a highly regulated physiological process leading to the generation of several neuroactive compounds within the central nervous system.
Ruddick, Jon P., Ruddick, JP, Evans, A, Rook, GA, Lowry, CA, Rook, Graham A. W., Lowry, Christopher A., Nutt, David J., Lightman, Stafford L., Lightman, SL, Evans, Andrew K., Nutt, DJ   +11 more
core   +1 more source

Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function

, 2022
The metabolism of dietary tryptophan occurs locally in the gut primarily via host enzymes, with similar to 5% metabolized by gut microbes. Three major tryptophan metabolic pathways are serotonin (beyond the scope of this review), indole, kynurenine and ...
Hornby, Pamela J., Hyland, Niall P., Cavanaugh, Cassandre R., Pamela J. Hornby, Cassandre R. Cavanaugh, Niall P. Hyland   +5 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis

Frontiers in Neuroscience, 2019
The link between gut microbiome and brain is being slowly acknowledged due to the speculated role of resident gut microbial community in altering the functions of gut-brain axis (GBA).
Harrisham Kaur, Chandrani Bose, Sharmila S. Mande   +2 more
doaj   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source