Results 111 to 120 of about 10,379 (248)

The metabolism of tryptophan. 3. The metabolism of 2-hydroxylaminobenzoic acid in relation to tryptophan metabolism [PDF]

Biochemical Journal, 1964
E, Boyland, A R, Fahmy
openaire   +2 more sources

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes

, 2005
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA
Newcombe, J, Kalina, P, Kepplinger, B, Baran, H, Ferraz-Leite, H, Kainz, A   +5 more
core  

Heterojunction‐Engineered Mass Spectrometry Platform for Deciphering Serum Metabolic Fingerprints in Diagnosis of Respiratory Diseases

Advanced Science, EarlyView.
Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen, Chaoqi Wang, Xi Yu, Yuming Jiang, Yijiao Qu, Huihui Fu, Yuyin Bu, Xiaoyong Zhang, Zongxiu Nie   +8 more
wiley   +1 more source

Integrated analysis of bulk and single-cell RNA sequencing reveals the impact of nicotinamide and tryptophan metabolism on glioma prognosis and immunotherapy sensitivity

BMC Neurology
Background Nicotinamide and tryptophan metabolism play important roles in regulating tumor synthesis metabolism and signal transduction functions. However, their comprehensive impact on the prognosis and the tumor immune microenvironment of glioma is ...
Sen Wang, Shen Gao, Shaochong Lin, Xiaofeng Fang, Haopeng Zhang, Man Qiu, Kai Zheng, Yupeng Ji, Baijun Xiao, Xiangtong Zhang   +9 more
doaj   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Understanding the Catalytic Determinant role of Diaphorase‐Like Subunit in Formate Dehydrogenases via Redox Couples

Advanced Science, EarlyView.
A unique mechanism of catalytic bias regulated by diaphorase‐like subunit in formate dehydrogenase from Rhodobacter aestuarii is revealed. The diaphorase‐like subunit functions act as a biological “voltage rheostat” that controls the slow release of NADH to regulate redox balance, biasing the enzyme's catalytic preference toward CO2 reduction over ...
Kuncheng Zhang, Weisong Liu, Hao Su, Huijuan Cui, Yuanming Wang, Zhiguang Zhu, Chun You, Lingling Zhang   +7 more
wiley   +1 more source

Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs

Advanced Science, EarlyView.
Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan, Haofeng Chen, Yan Wang, Junyi Wang, Yueyang Chen, Yang Zhang, Jinting Guan, Jifeng Yuan   +7 more
wiley   +1 more source

Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila

Gut Microbes
The gut microbiota plays a pivotal role in anxiety regulation through pathways involving neurotransmitter production, immune signaling, and metabolic interactions.
Miaomiao Pan, Chenglang Qian, Shaoye Huo, Yuchen Wu, Xinyi Zhao, Yueming Ying, Boyu Wang, Hao Yang, Anaguli Yeerken, Tongyao Wang, Mengwei Fu, Lihong Wang, Yuhuan Wei, Yunhua Zhao, Chunhai Shao, Huijing Wang, Chao Zhao   +16 more
doaj   +1 more source

Role of Tryptophan Metabolism in Cancer

Cancer Innovation
ABSTRACT Tryptophan (Trp) is an essential amino acid that serves as a precursor for the synthesis of several important bioactive compounds. Trp is involved in a variety of pathophysiological processes, including neuronal function, metabolism, inflammatory responses, oxidative stress, immune regulation, and intestinal homeostasis.
Zhehao Cui, Dandan Wang, Ye Zhang, Long Yuan, Yi Zhang, Xiaowei Qi   +5 more
openaire   +2 more sources