Results 131 to 140 of about 10,379 (248)
Angewandte Chemie, EarlyView.Hsf1 undergoes phase separation around target DNA, activating stress‐responsive transcription. DNA binding tunes conformational dynamics of Hsf1DBD, which propagates through large‐scale domain rearrangements involving DBD–IDR interactions to regulate phase separation. This hierarchical framework illustrates how local structural events at the side chain
Soichiro Kawagoe +2 more
wiley +2 more sources
RheumatologyObjectives The importance of the kynurenine pathway in normal immune system function has led to an appreciation of its possible contribution to autoimmune disorders such as rheumatoid arthritis (RA).
Joanna Witoszyńska-Sobkowiak +5 more
doaj +1 more source
Analysis of model of tryptophan metabolism
, 2020 Matematičko modeliranje daje nam na jednostavan i ponovljiv način detaljan uvid na metaboličke procese koji se zbivaju u stanicama. Metabolizam triptofana uglavnom se odvija preko kinureninskoga puta pri kojem nastaju metaboliti zajedničkoga naziva ...
Karatović, Anja
core
Advanced Science, EarlyView.Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee +9 more
wiley +1 more source
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, EarlyView.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources
PLoS ONEBackgroundTryptophan metabolism is involved in the progression and immune response of multiple diseases. However, the function of tryptophan metabolism in the immune characteristics of sepsis still needs to be elucidated.MethodsWe collected the datasets ...
Li-Hong Chen +4 more
doaj +1 more source
Metabolomics study of 3-O-p-(Z/E)-coumaroyltormentic acid-treated Trypanosoma brucei brucei
International Journal for Parasitology: Drugs and Drug ResistanceTrypanosomiasis is a parasitic disease for which new treatments are needed due to the frequent occurrence of adverse side effects of current available drugs.
Lúcia Mamede +9 more
doaj +1 more source
Tryptophan, phenylalanine and tyrosine metabolism.
, 2014 (A) Graphs represent the ScaledImpData of different biochemicals of the tryptophan metabolism from heart tissue samples. (B) Same as in A from plasma samples (C) A Graphs represent the ScaledImpData of different biochemicals of the phenylalanine and ...
Sofía Carbajosa (420515) +5 more
core +1 more source
Advanced Science, EarlyView.Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang +19 more
wiley +1 more source