Results 141 to 150 of about 119,637 (295)

The kynurenine pathway in patients with rheumatoid arthritis during tumor necrosis factor α inhibitors treatment

Rheumatology
Objectives The importance of the kynurenine pathway in normal immune system function has led to an appreciation of its possible contribution to autoimmune disorders such as rheumatoid arthritis (RA).
Joanna Witoszyńska-Sobkowiak, Dorota Sikorska, Karolina Niklas, Iwona Żychowska, Rafał Rutkowski, Włodzimierz Samborski   +5 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Identification and validation of the important role of tryptophan-related gene CYP1B1 in the development and progression of sepsis.

PLoS ONE
BackgroundTryptophan metabolism is involved in the progression and immune response of multiple diseases. However, the function of tryptophan metabolism in the immune characteristics of sepsis still needs to be elucidated.MethodsWe collected the datasets ...
Li-Hong Chen, Wei-Ru Lin, Hui-Rong Hu, Zhi-Yuan Chen, Yan-Hui Wang   +4 more
doaj   +1 more source

Metabolomics study of 3-O-p-(Z/E)-coumaroyltormentic acid-treated Trypanosoma brucei brucei

International Journal for Parasitology: Drugs and Drug Resistance
Trypanosomiasis is a parasitic disease for which new treatments are needed due to the frequent occurrence of adverse side effects of current available drugs.
Lúcia Mamede, Fanta Fall, Madeline Vast, Kristelle Hughes, Giorgia Martelli, Francesco Caligiore, Bernadette Govaerts, Paul A.M. Michels, Michel Frédérich, Joëlle Quetin-Leclercq   +9 more
doaj   +1 more source

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

Annals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera, Rossella Di Sapia, Greta Volpedo, Sneha Anand, Eray Sahin, Pasquale Baldassarre, Francesca Buffelli, Andrea Petretto, Chiara Lavarello, James D. Mills, Gabriele Cattaneo, Ilaria Craparotta, Eleonora Aronica, Antonella Riva, Pasquale Striano, Annamaria Vezzani, Teresa Ravizza   +16 more
wiley   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Tryptophan metabolism and age-related cataract [PDF]

, 2009
The most common cause for human bhndness is cataract. Surgery is the only available treatment and the cause of cataract is unknown. The aim of this project was to determine if a difference could be discerned in the metabohsm of the essential amino acid ...
Anthony James Elderfield (20158149)
core  

PyrH and PrnB crystal structures [PDF]

, 2006
Determination of the three-dimensional structure of enzymes at atomic resolution is a key prerequisite for elucidation of molecular mechanisms of catalysis and catalysis mechanism prediction.
De Laurentis, Walter
core  

Influence of Xiaoyaosan on depressive-like behaviors in chronic stress-depressed rats through regulating tryptophan metabolism in hippocampus

Neuropsychiatric Disease and Treatment, 2018
Haiyan Jiao,1,* Zhiyi Yan,1,* Qingyu Ma,2 Xiaojuan Li,2 Youming Jiang,1 Yueyun Liu,1 Jiaxu Chen1,2 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; 2Formula-Pattern Research Center, School of ...
Jiao H, Yan Z, Ma Q, Li X, Jiang Y, Liu Y, Chen J   +6 more
doaj  

TRYPTOPHANE METABOLISM

Journal of Biological Chemistry, 1932
Clarence P. Berg, Martha Potgieter
openaire   +2 more sources