Results 11 to 20 of about 10,379 (248)
The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism
Metabolites, 2023 Tryptophan is metabolized along three main metabolic pathways, namely the kynurenine, serotonin and indole pathways. The majority of tryptophan is transformed via the kynurenine pathway, catalyzed by tryptophan-2,3-dioxygenase or indoleamine-2,3 ...
Anna Haduch +3 more
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MetabolitesBackground: The early nutritional metabolism of piglets is intimately associated with the regulation of immune function, and amino acids play a crucial role in modulating the fate and function of porcine immune cells, especially macrophages. However, the
Meimei Zhang +3 more
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Deciphering tryptophan metabolism in colorectal cancer through multi-omics analysis
Biochemistry and Biophysics ReportsMetabolic reprogramming is essential for colorectal cancer (CRC) progression, and recent studies have pointed to tryptophan metabolism as a crucial modulator of the tumor immune microenvironment.
Chengcheng Zhang +14 more
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Altered Tryptophan and Neopterin Metabolism In Cancer Patients
Pteridines, 1998 Plasma 5-hydroxytryptamine (serotonin), tryptophan and neopterin levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period.
Iwagaki Hiromi +3 more
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Tryptophan Metabolism and Gut-Brain Homeostasis
, 2021 Tryptophan is an essential amino acid critical for protein synthesis in humans that has emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the neurotransmitter serotonin, which is vital for the processing of emotional ...
Kimia Zadeh +4 more
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Tryptophan metabolism in bipolar disorder
European Psychiatry, 2022 Introduction Immune mediated inflammatory processes are involved in the aetiopathogenesis of bipolar disorder (BD) and weight associated comorbidities. Tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) along the kynurenine axis concomitant ...
F. Fellendorf +11 more
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, 2021 Scientific interest in tryptophan metabolism via the kynurenine pathway (KP) has increased in the last decades. Describing its metabolites helped to increase their roles in many diseases and disturbances, many of a pro-inflammatory nature.
Małgorzata Kiluk +3 more
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Metabolites, 2023 Tryptophan metabolism and gut microbiota form an integrated regulatory axis that impacts immunity, metabolism, and cancer. This review consolidated current knowledge on the bidirectional interactions between microbial tryptophan processing and the host ...
Yingjian Hou, Jing Li, Shuhuan Ying
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Tryptophan Metabolism in Alcoholism [PDF]
Nutrition Research Reviews, 1999 Studies of tryptophan (Trp) metabolism in relation to the serotonin status in alcoholism are of 2 types: (1) those related to the pharmacological effects of ethanol; (2) those concerning the serotonin status in the absence of alcohol intake. In experimental animals, acute and chronic ethanol administration and subsequent withdrawal exert a variety of ...
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Structural insights into the basis and evolution of interactions in multi-subunit protein assemblies. tryptophan synthase and titin FNIII-repeats [PDF]
, 2008 Cellular processes benefit from evolutionary shaping when optimized protein-protein interactions result in enhanced functionality. In fact, most cellular proteins are tightly embedded into biological networks that function following a modularity ...
Bucher, Rainer Michael
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