Results 1 to 10 of about 2,520,144 (213)

Cytotoxic Effects of Kynurenic Acid and Quinaldic Acid in Hepatocellular Carcinoma (HepG2) Cell Line

Proceedings, 2017
Kynurenic acid (KYNA), tryptophan metabolite synthesized in the kynurenine pathway, is present in human body fluids as well as in variety of foods, herbal medicines and honeybee derived foodstuffs.
Pınar Atalay Dündar, N. Nalan İmamoğlu   +1 more
doaj   +1 more source

Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review

Journal of Neuroinflammation, 2020
Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi, Osama Elyamany, Christoph Rummel, Christoph Mulert   +3 more
doaj   +1 more source

Physicochemical Characterization of Kynurenine Pathway Metabolites

Antioxidants
The kynurenine pathway is a significant metabolic route involved in the catabolism of tryptophan, producing various bioactive metabolites with crucial roles as antioxidants in immune regulation and neurobiology.
Luca Buzásy, Károly Mazák, Balázs Balogh, Balázs Simon, Anna Vincze, György Tibor Balogh, Tamás Pálla, Arash Mirzahosseini   +7 more
doaj   +1 more source

Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s disease

npj Parkinson's Disease
We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson’s disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD (“OFF”), 86 controls); CSF ...
Leslie C. Jellen, Martha L. Escobar Galvis, Qiong Sha, Christine Isaguirre, Amy Johnson, Zach Madaj, Mechelle M. Lewis, Ryan D. Sheldon, Lan Kong, Xuemei Huang, Lena Brundin   +10 more
doaj   +1 more source

Lactobacillus regulate muscle fiber type conversion in Chinese native pigs via tryptophan metabolism

npj Biofilms and Microbiomes
Identifying potential gut microbes and metabolites that can influence muscle fiber type is gaining interest in meat quality research. In this study, muscle fiber characteristics, muscle metabolite profiles, and gut microbiota and metabolome were compared
Bo Song, Md. Abul Kalam Azad, Qian Zhu, Yating Cheng, Sujuan Ding, Kang Yao, Xiangfeng Kong   +6 more
doaj   +1 more source

Losartan Reverses Hippocampal Increase of Kynurenic Acid in Type 1 Diabetic Rats: A Novel Procognitive Aspect of Sartan Action

Journal of Diabetes Research, 2019
Patients with diabetes mellitus (DM) type 1 and 2 are at a higher risk of cognitive decline and dementia; however, the underlying pathology is poorly understood.
Iwona Chmiel-Perzyńska, Adam Perzyński, Bartosz Olajossy, Paulina Gil-Kulik, Janusz Kocki, Ewa M. Urbańska   +5 more
doaj   +1 more source

Activation of nociception‐sensitive ionotropic glutamate receptor‐expressing rostroventrolateral medulla neurons by stimulation of cardiac afferents in rats

FASEB BioAdvances
Myocardial ischemia causes the release of bradykinin, which activates afferent nerve endings in the ventricular epicardium. This elicits a sympathetically mediated increase in arterial pressure and heart rate, referred to as the cardiogenic sympathetic ...
Matthew R. Zahner, Cade C. Oculam, Eric Beaumont   +2 more
doaj   +1 more source

Tryptophan metabolites clearance in hemodialyzed patients

Amino Acids
Hemodialysis (HD) and hemodiafiltration (HDF) procedures have limited efficacy regarding removal of selected toxins. Tryptophan (Trp) metabolites formed through the kynurenine (KYN) pathway are known to contribute to kidney failure (KF) complications ...
Izabela Zakrocka, Radosław Mlak, Natalia Moniczewska, Sylwia Boczkowska, Renata Kloc, Tomasz Kocki, Ewa M. Urbańska, Wojciech Załuska, Andreas Kronbichler   +8 more
doaj   +1 more source

Feeding Experiments with Kynurenic Acid [PDF]

Biochemical Journal, 1916
openaire   +2 more sources

The Metabolism of Kynurenic Acid

Journal of Biological Chemistry, 1961
Kengo Horibata, Hiroshi Taniuchi, Minoru Tashiro, Sigeru Kuno, Osamu Hayaishi   +4 more
openaire   +1 more source