Results 1 to 10 of about 19,359 (226)
Importance of Modulating Kynurenic Acid Metabolism—Approaches for the Treatment of Dementia [PDF]
BiomoleculesIn this article, we focus on kynurenic acid metabolism in neuropsychiatric disorders and the biochemical processes involved in memory and cognitive impairment, followed by different approaches in the fight against dementia.
Halina Baran +2 more
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Probiotics-enhanced kynurenic acid mitigates cisplatin-induced nephrotoxicity in mice [PDF]
iScienceSummary: Cisplatin chemotherapy is limited by dose-dependent nephrotoxicity. This study investigates the nephroprotective potential of kynurenic acid (KYNA), a tryptophan metabolite, against cisplatin-induced renal injury.
Kangxin Li +8 more
doaj +2 more sources
Effects of kynurenic acid on cardiovascular system
Journal of Education, Health and Sport, 2017 Kynurenic Acid (KYNA) is an endogenous metabolite of tryptophan (TRP) which is produced by aminotransferase KAT I and KAT II in the central nervous system and peripheral tissues. Moreover it has been shown that it can be supplied with food.
Piotr Kozłowski +2 more
doaj +4 more sources
Selective heterofunctionalization of kynurenic acid derivatives. [PDF]
RSC AdvThe current study presents selective halogenation of kynurenic acid analogues and further transformation thereof.
Törteli L +3 more
europepmc +2 more sources
LC-MS/MS Detection of Tryptophan, Kynurenine, Kynurenic Acid, and Quinolinic Acid in Urine Samples from Drug-Positive and Illicit Drug-Negative Patients with a Known History of Substance Use Disorder [PDF]
MetabolitesIntroduction: Currently, there are few tools for monitoring recovery in substance use disorder. As substance use has increased in prevalence, tools for measuring recovery are needed to improve therapeutic outcomes.
Lindsey Contella +8 more
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Determination of Bioactive Compound Kynurenic Acid in Linum usitatissimum L. [PDF]
MoleculesKynurenic acid (KYNA) is a bioactive compound exhibiting multiple actions and positive effects on human health due to its antioxidant, anti-inflammatory and neuroprotective properties.
Magdalena Wróbel-Kwiatkowska +5 more
doaj +2 more sources
SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier
Pharmaceutics, 2021 By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through the ...
Kinga Molnár +10 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Yarrowia lipolytica yeast are able to produce kynurenic acid—a very valuable compound acting as a neuroprotective and antioxidant agent in humans. The recent data proved the existence of the kynurenine biosynthesis pathway in this yeast cells.
Magdalena Rakicka-Pustułka +5 more
doaj +1 more source
Journal of Pharmaceutical Analysis, 2023 Renal tubular secretion mediated by organic anion transporters (OATs) and the multidrug resistance-associated protein 4 (MRP4) is an important means of drug and toxin excretion. Unfortunately, there are no biomarkers to evaluate their function.
Yanrong Ma +5 more
doaj +1 more source
EBioMedicine, 2022 Summary: Background: Epileptic (previously infantile) spasms is the most common epileptic encephalopathy occurring during infancy and is frequently associated with abnormal neurodevelopmental outcomes.
Jingya Yan +22 more
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