Results 1 to 10 of about 2,696,733 (168)
Importance of Modulating Kynurenic Acid Metabolism—Approaches for the Treatment of Dementia [PDF]
BiomoleculesIn this article, we focus on kynurenic acid metabolism in neuropsychiatric disorders and the biochemical processes involved in memory and cognitive impairment, followed by different approaches in the fight against dementia.
Halina Baran +2 more
doaj +3 more sources
SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier
Pharmaceutics, 2021 By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through the ...
Kinga Molnár +10 more
doaj +2 more sources
Probiotics-enhanced kynurenic acid mitigates cisplatin-induced nephrotoxicity in mice [PDF]
iScienceSummary: Cisplatin chemotherapy is limited by dose-dependent nephrotoxicity. This study investigates the nephroprotective potential of kynurenic acid (KYNA), a tryptophan metabolite, against cisplatin-induced renal injury.
Kangxin Li +8 more
doaj +2 more sources
LC-MS/MS Detection of Tryptophan, Kynurenine, Kynurenic Acid, and Quinolinic Acid in Urine Samples from Drug-Positive and Illicit Drug-Negative Patients with a Known History of Substance Use Disorder [PDF]
MetabolitesIntroduction: Currently, there are few tools for monitoring recovery in substance use disorder. As substance use has increased in prevalence, tools for measuring recovery are needed to improve therapeutic outcomes.
Lindsey Contella +8 more
doaj +2 more sources
Frontiers in Bioengineering and Biotechnology, 2022 Yarrowia lipolytica yeast are able to produce kynurenic acid—a very valuable compound acting as a neuroprotective and antioxidant agent in humans. The recent data proved the existence of the kynurenine biosynthesis pathway in this yeast cells.
Magdalena Rakicka-Pustułka +5 more
doaj +1 more source
Journal of Pharmaceutical Analysis, 2023 Renal tubular secretion mediated by organic anion transporters (OATs) and the multidrug resistance-associated protein 4 (MRP4) is an important means of drug and toxin excretion. Unfortunately, there are no biomarkers to evaluate their function.
Yanrong Ma +5 more
doaj +1 more source
EBioMedicine, 2022 Summary: Background: Epileptic (previously infantile) spasms is the most common epileptic encephalopathy occurring during infancy and is frequently associated with abnormal neurodevelopmental outcomes.
Jingya Yan +22 more
doaj +1 more source
Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome
Frontiers in Endocrinology, 2022 BackgroundWomen with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS.
Siyu Wang +25 more
doaj +1 more source
Microorganisms, 2021 In children, tick-borne encephalitis and neuroborreliosis are common infections affecting the central nervous system. As inflammatory pathways including cytokine expression are activated in these children and appear to be of importance for outcome, we ...
Ronny Wickström +5 more
doaj +1 more source
Scientific Reports, 2022 Monosodium glutamate induces behaviors thought to reflect headache and nausea in rats. We explored the effects of the N-methyl-d-aspartate receptor antagonist (2R)-amino-5-phosphonovaleric acid, the inotropic glutamate receptor antagonist kynurenic acid,
Tarique Benbow +5 more
doaj +1 more source