Results 1 to 10 of about 19,595 (226)

SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier

Pharmaceutics, 2021
By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through the ...
Kinga Molnár, Bálint Lőrinczi, Csilla Fazakas, István Szatmári, Ferenc Fülöp, Noémi Kmetykó, Róbert Berkecz, István Ilisz, István A. Krizbai, Imola Wilhelm, László Vécsei   +10 more
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The microbial production of kynurenic acid using Yarrowia lipolytica yeast growing on crude glycerol and soybean molasses

Frontiers in Bioengineering and Biotechnology, 2022
Yarrowia lipolytica yeast are able to produce kynurenic acid—a very valuable compound acting as a neuroprotective and antioxidant agent in humans. The recent data proved the existence of the kynurenine biosynthesis pathway in this yeast cells.
Magdalena Rakicka-Pustułka, Patrycja Ziuzia, Jan Pierwoła, Kacper Szymański, Magdalena Wróbel-Kwiatkowska, Zbigniew Lazar   +5 more
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Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel

Journal of Pharmaceutical Analysis, 2023
Renal tubular secretion mediated by organic anion transporters (OATs) and the multidrug resistance-associated protein 4 (MRP4) is an important means of drug and toxin excretion. Unfortunately, there are no biomarkers to evaluate their function.
Yanrong Ma, Fenglin Ran, Mingyan Xin, Xueyan Gou, Xinyi Wang, Xinan Wu   +5 more
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Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids

EBioMedicine, 2022
Summary: Background: Epileptic (previously infantile) spasms is the most common epileptic encephalopathy occurring during infancy and is frequently associated with abnormal neurodevelopmental outcomes.
Jingya Yan, Kavitha Kothur, Emily A. Innes, Velda X. Han, Hannah F. Jones, Shrujna Patel, Erica Tsang, Richard Webster, Sachin Gupta, Christopher Troedson, Manoj P. Menezes, Jayne Antony, Simone Ardern-Holmes, Esther Tantsis, Shekeeb Mohammad, Louise Wienholt, Ananda S. Pires, Benjamin Heng, Gilles J. Guillemin, Anna Guller, Deepak Gill, Sushil Bandodkar, Russell C. Dale   +22 more
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Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome

Frontiers in Endocrinology, 2022
BackgroundWomen with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS.
Siyu Wang, Siyu Wang, Siyu Wang, Liangshan Mu, Liangshan Mu, Chunmei Zhang, Chunmei Zhang, Xiaoyu Long, Xiaoyu Long, Yurong Zhang, Yurong Zhang, Yurong Zhang, Rong Li, Rong Li, Rong Li, Rong Li, Yue Zhao, Yue Zhao, Yue Zhao, Yue Zhao, Yue Zhao, Jie Qiao, Jie Qiao, Jie Qiao, Jie Qiao, Jie Qiao   +25 more
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The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis

Microorganisms, 2021
In children, tick-borne encephalitis and neuroborreliosis are common infections affecting the central nervous system. As inflammatory pathways including cytokine expression are activated in these children and appear to be of importance for outcome, we ...
Ronny Wickström, Åsa Fowler, Michel Goiny, Vincent Millischer, Sofia Ygberg, Lilly Schwieler   +5 more
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Peripheral N-methyl-d-aspartate receptor activation contributes to monosodium glutamate-induced headache but not nausea behaviours in rats

Scientific Reports, 2022
Monosodium glutamate induces behaviors thought to reflect headache and nausea in rats. We explored the effects of the N-methyl-d-aspartate receptor antagonist (2R)-amino-5-phosphonovaleric acid, the inotropic glutamate receptor antagonist kynurenic acid,
Tarique Benbow, Felisha Teja, Afrooz Sheikhi, Fernando G. Exposto, Peter Svensson, Brian E. Cairns   +5 more
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“Kynurenine switch” and obesity

Бюллетень сибирской медицины, 2022
Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov, O. P. Shatova, M. S. Karbyshev, A. M. Gaponov, N. E. Moskaleva, S. A. Appolonova, A. V. Tutelyan, V. V. Makarov, S. M. Yudin, S. A. Roumiantsev   +9 more
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Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

The Journal of Headache and Pain, 2021
Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs.
Eleonóra Spekker, Klaudia Flóra Laborc, Zsuzsanna Bohár, Gábor Nagy-Grócz, Annamária Fejes-Szabó, Mónika Szűcs, László Vécsei, Árpád Párdutz   +7 more
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Direct determination of kynurenic acid with HPLC-MS/MS method in honey

Acta Chimica Slovenica, 2023
Kynurenic acid (KYNA) has been attributed many beneficial properties, such as antioxidant, antiproliferative, anti-inflammatory, and anti-obesogenic, as it is believed to affect metabolism and weight gain.
Anže Pavlin, Matevž Pompe, Drago Kočar   +2 more
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