Results 21 to 30 of about 12,136 (185)
Scientific Reports, 2020 Since optimal treatment at an early stage leads to remission of symptoms and recovery of function, putative biomarkers leading to early diagnosis and prediction of therapeutic responses are desired.
Hisayuki Erabi +11 more
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Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters. [PDF]
PLoS ONE, 2018 The mammalian kynurenine aminotransferase (KAT) enzymes are a family of related isoforms that are pyridoxal 5'-phosphate-dependent, responsible for the irreversible transamination of kynurenine to kynurenic acid.
Gayan S Jayawickrama +3 more
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Kynurenic acid and cancer: facts and controversies [PDF]
Cellular and Molecular Life Sciences, 2019 Abstract Kynurenic acid (KYNA) is an endogenous tryptophan metabolite exerting neuroprotective and anticonvulsant properties in the brain. However, its importance on the periphery is still not fully elucidated. KYNA is produced endogenously in various types of peripheral cells, tissues and by gastrointestinal microbiota.
Katarzyna Walczak +3 more
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Kynurenic Acid and Kynurenine Aminotransferase in Heart [PDF]
Pediatric Research, 1997 Kynurenic acid (KYNA) is a tryptophan metabolite and represents the only known endogenous compound acting as an antagonist to excitatory amino acid receptors in the mammalian CNS. Blocking of these receptors in CNS by KYNA affects cardiac function.
H, Baran, G, Amann, B, Lubec, G, Lubec
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npj Breast Cancer, 2021 Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among ...
Oana A. Zeleznik +8 more
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Cells, 2022 Glutamate-receptor-mediated hyperexcitability contributes to seizure generation in temporal lobe epilepsy (TLE). Tryptophan–kynurenine pathway (TKP) metabolites regulate glutamate receptor activity under physiological conditions.
Soumil Dey +5 more
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Metabolites, 2017 The aim of this pilot study is to evaluate sarcosine, uracil, and kynurenic acid in urine as potential biomarkers in prostate cancer detection and progression monitoring. Sarcosine, uracil, and kynurenic acid were measured in urine samples of 32 prostate
Georgios Gkotsos +6 more
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European Psychiatry, 2021 Introduction The tryptophan pathway along with its two branches of metabolism to serotonin and kynurenine seems to be affected in major depression.
R. Colle +4 more
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LifeKynurenic acid is a tryptophan (Trp) metabolite formed along the kynurenine (KYN) pathway in the brain and in peripheral tissues. The disturbed formation of kynurenic acid, which targets glutamate-mediated neurotransmission, GPR35, and aryl hydrocarbon ...
Kinga Bednarz +2 more
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BMC Psychiatry, 2023 Previous studies reported significantly altered tryptophan catabolite concentrations in major depression. Thus, tryptophan catabolites were considered as potential biomarkers of depression and their modulators as potential targets for ...
Matthias Michal +13 more
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