Results 21 to 30 of about 2,696,733 (168)

Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis

Scientific Reports, 2020
Since optimal treatment at an early stage leads to remission of symptoms and recovery of function, putative biomarkers leading to early diagnosis and prediction of therapeutic responses are desired.
Hisayuki Erabi, Go Okada, Chiyo Shibasaki, Daiki Setoyama, Dongchon Kang, Masahiro Takamura, Atsuo Yoshino, Manabu Fuchikami, Akiko Kurata, Takahiro A. Kato, Shigeto Yamawaki, Yasumasa Okamoto   +11 more
doaj   +1 more source

Kynurenic acid as chronic pain biomarker for future cancer pain management [PDF]

, 2022
The prevalence of chronic pain ranges from 30-50% in patients with cancer undergoing active therapy. Kynurenic acid, xanthurenic acid, and quinolinic acid are significant biomarkers for assessing pain objectively.
Soni Sunarso Sulistiawan, Pudjirahardjo, Widodo J., Waloejo, Christrijogo Soemartono, Andriyanto, Lucky, Kurniasari, Hamidah, Widodo J. Pudjirahardjo, Aditya B. Farhan, Hamidah Kurniasari, Farhan, Aditya B., Nancy Margarita Rehatta, Lucky Andriyanto, Christrijogo Soemartono Waloejo, Chen, Yi-Hung, Rehatta, Nancy Margarita, Sulistiawan, Soni Sunarso, Yi-Hung Chen   +15 more
core   +1 more source

Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia

Biomolecules, 2023
Preeclampsia (PE) is a pregnancy-related disorder characterized by high blood pressure and proteinuria in the third trimester. The disease is associated with many metabolic and biochemical changes.
Zainab Abdulameer Jasim, Hussein Kadhem Al-Hakeim, Samaneh Zolghadri, Agata Stanek   +3 more
doaj   +1 more source

The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]

Medicinski Podmladak, 2023
The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš, Nikolić Tatjana, Totić-Poznanović Sanja   +2 more
doaj   +1 more source

Effects of kynurenic acid on cardiovascular system

Journal of Education, Health and Sport, 2017
Kynurenic Acid (KYNA) is an endogenous metabolite of tryptophan (TRP) which is produced by aminotransferase KAT I and KAT II in the central nervous system and peripheral tissues. Moreover it has been shown that it can be supplied with food.
Piotr Kozłowski, Magdalena Kozłowska, Karolina Kozłowska   +2 more
doaj   +3 more sources

Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters. [PDF]

PLoS ONE, 2018
The mammalian kynurenine aminotransferase (KAT) enzymes are a family of related isoforms that are pyridoxal 5'-phosphate-dependent, responsible for the irreversible transamination of kynurenine to kynurenic acid.
Gayan S Jayawickrama, Alireza Nematollahi, Guanchen Sun, William Bret Church   +3 more
doaj   +1 more source

Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women

npj Breast Cancer, 2021
Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among ...
Oana A. Zeleznik, Raji Balasubramanian, Yibai Zhao, Lisa Frueh, Sarah Jeanfavre, Julian Avila-Pacheco, Clary B. Clish, Shelley S. Tworoger, A. Heather Eliassen   +8 more
doaj   +1 more source

Differential Levels of Tryptophan–Kynurenine Pathway Metabolites in the Hippocampus, Anterior Temporal Lobe, and Neocortex in an Animal Model of Temporal Lobe Epilepsy

Cells, 2022
Glutamate-receptor-mediated hyperexcitability contributes to seizure generation in temporal lobe epilepsy (TLE). Tryptophan–kynurenine pathway (TKP) metabolites regulate glutamate receptor activity under physiological conditions.
Soumil Dey, Vivek Dubey, Aparna Banerjee Dixit, Manjari Tripathi, Poodipedi Sarat Chandra, Jyotirmoy Banerjee   +5 more
doaj   +1 more source

The Role of Sarcosine, Uracil, and Kynurenic Acid Metabolism in Urine for Diagnosis and Progression Monitoring of Prostate Cancer

Metabolites, 2017
The aim of this pilot study is to evaluate sarcosine, uracil, and kynurenic acid in urine as potential biomarkers in prostate cancer detection and progression monitoring. Sarcosine, uracil, and kynurenic acid were measured in urine samples of 32 prostate
Georgios Gkotsos, Christina Virgiliou, Ioanna Lagoudaki, Chrysanthi Sardeli, Nikolaos Raikos, Georgios Theodoridis, Georgios Dimitriadis   +6 more
doaj   +1 more source

Peripheral tryptophan and serotonin and kynurenine pathways in major depression: A case-control study

European Psychiatry, 2021
Introduction The tryptophan pathway along with its two branches of metabolism to serotonin and kynurenine seems to be affected in major depression.
R. Colle, C. Verstuyft, D. David, P. Chanson, E. Corruble   +4 more
doaj   +1 more source