Results 11 to 20 of about 19,595 (226)

Selective heterofunctionalization of kynurenic acid derivatives [PDF]

RSC Advances
The current study presents selective halogenation of kynurenic acid analogues and further transformation thereof.
Levente Törteli, Péter Simon, Róbert Berkecz, István Szatmári   +3 more
openaire   +3 more sources

Importance of Modulating Kynurenic Acid Metabolism—Approaches for the Treatment of Dementia [PDF]

Biomolecules
In this article, we focus on kynurenic acid metabolism in neuropsychiatric disorders and the biochemical processes involved in memory and cognitive impairment, followed by different approaches in the fight against dementia.
Halina Baran, Marcelin Jan Pietryja, Berthold Kepplinger   +2 more
doaj   +2 more sources

Effects of kynurenic acid on cardiovascular system

Journal of Education, Health and Sport, 2017
Kynurenic Acid (KYNA) is an endogenous metabolite of tryptophan (TRP) which is produced by aminotransferase KAT I and KAT II in the central nervous system and peripheral tissues. Moreover it has been shown that it can be supplied with food.
Piotr Kozłowski, Magdalena Kozłowska, Karolina Kozłowska   +2 more
doaj   +4 more sources

Probiotics-enhanced kynurenic acid mitigates cisplatin-induced nephrotoxicity in mice [PDF]

iScience
Summary: Cisplatin chemotherapy is limited by dose-dependent nephrotoxicity. This study investigates the nephroprotective potential of kynurenic acid (KYNA), a tryptophan metabolite, against cisplatin-induced renal injury.
Kangxin Li, Hui Yuan, Jieyan Wang, Jiaxin Ou, Guiming Chen, Shiyu Li, Qudi Qiao, Qiannan Deng, Shu-Lan Qin   +8 more
doaj   +2 more sources

LC-MS/MS Detection of Tryptophan, Kynurenine, Kynurenic Acid, and Quinolinic Acid in Urine Samples from Drug-Positive and Illicit Drug-Negative Patients with a Known History of Substance Use Disorder [PDF]

Metabolites
Introduction: Currently, there are few tools for monitoring recovery in substance use disorder. As substance use has increased in prevalence, tools for measuring recovery are needed to improve therapeutic outcomes.
Lindsey Contella, Christopher L. Farrell, Luigi Boccuto, Alain H. Litwin, Hunter Flanagan, Stacy E. F. Melanson, Nicole V. Tolan, Marion L. Snyder, Dina N. Greene   +8 more
doaj   +2 more sources

Determination of Bioactive Compound Kynurenic Acid in Linum usitatissimum L. [PDF]

Molecules
Kynurenic acid (KYNA) is a bioactive compound exhibiting multiple actions and positive effects on human health due to its antioxidant, anti-inflammatory and neuroprotective properties.
Magdalena Wróbel-Kwiatkowska, Waldemar Turski, Grażyna Silska, Magdalena Rakicka-Pustułka, Lucyna Dymińska, Waldemar Rymowicz   +5 more
doaj   +2 more sources

Reactions of kynurenic acid with hypobromous acid and hypochlorous acid

Journal of Clinical Biochemistry and Nutrition, 2021
Kynurenic acid, a tryptophan metabolite, acts as antagonist or agonist of several receptors. Hypobromous acid (HOBr) and hypochlorous acid (HOCl) are generated by eosinophils and neutrophils. At inflammation sites, kynurenic acid may encounter HOBr and HOCl to generate products.
Suzuki, Toshinori, Morishita, Hiroyuki, Fukuhara, Kosumo   +2 more
openaire   +3 more sources

Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction

Frontiers in Endocrinology, 2023
ObjectiveSepsis is a life-threatening condition secondary to infection that evolves into a dysregulated host response and is associated with acute organ dysfunction.
Yan Cao, Yan Cao, Zhengyu Liu, Zhengyu Liu, Wenfeng Ma, Chen Fang, Yanfang Pei, Yingxia Jing, Jie Huang, Xiaotong Han, Xiaotong Han, Weiwei Xiao   +11 more
doaj   +1 more source

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders [PDF]

, 2013
Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders.
Akagbosu, Akladios, Alexander, Alkondon, Alkondon, Alkondon, Amori, Andersen, Atlas, Autier, Backman, Beal, Benatti, Bonda, Breese, Carpenedo, Carpenedo, Casazza, Castellano, Ceresoli-Borroni, Cesura, Chess, Chess, Chess, Chiarugi, Chiarugi, Clark, Cochran, Cozzi, Cui, Daily, Dalley, Dantzer, Darlington, Darlington, Davidson, Deiana, Della Torre, DiNatale, Dobelis, Dounay, Eastman, Erhardt, Forrest, Forrest, Forrest, Forrest, Fukui, Gellert, Giordani, Giorgini, Gold, Graef, Guidetti, Guidetti, Guidetti, Guidetti, Guillemin, Guillemin, Hardingham, Hedges, Henderson, Heng, Hernandez, Heyes, Hilmas, Holtze, Jason, Jauch, Jentsch, Jurgens, Kalisch, Kandanearatchi, Kiank, Kihara, Kloet, Kocki, Konradsson-Geuken, Lawrence, Lawrence, Linderholm, Lindsley, Luchowski, Luchowski, Lupien, Marin, Mexal, Millan, Miller, Minzenberg, Miura, Moeller, Mok, Muchowski, Muchowski, Mueller, Muscatell, Myint, Nagy, Neill, Newcomer, Newcomer, Nilsson, Nilsson, Nozaki, O'Connor, Olsson, Onur, Owe-Young, Paterson, Pearson, Pechtel, Pellicciari, Pellicciari, Perkins, Pertovaara, Pevarello, Phillips, Pocivavsek, Pocivavsek, Popoli, Popoli, Potter, Rahman, Raison, Rassoulpour, Ren, Robert, Rodgers, Rossi, Ryu, Röver, Saito, Salazar, Sapko, Sarter, Sathyasaikumar, Sathyasaikumar, Schwarcz, Schwarcz, Schwarcz, Schwarcz, Shear, Speciale, Speciale, Stazka, Stazka, Stone, Stone, Stone, Stone, Stone, Stoy, Tadaiesky, Tatter, Teichberg, Teichberg, Ting, Trecartin, Tse, Varasi, Vezzani, Walker, Wang, Wang, Wejksza, Wejksza, Wonodi, Xu, Yamada, Yuen, Zisapel, Zmarowski   +172 more
core   +1 more source

The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]

Medicinski Podmladak, 2023
The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš, Nikolić Tatjana, Totić-Poznanović Sanja   +2 more
doaj   +1 more source