Results 11 to 20 of about 2,696,733 (168)
LifeKynurenic acid is a tryptophan (Trp) metabolite formed along the kynurenine (KYN) pathway in the brain and in peripheral tissues. The disturbed formation of kynurenic acid, which targets glutamate-mediated neurotransmission, GPR35, and aryl hydrocarbon ...
Kinga Bednarz +2 more
doaj +2 more sources
Selective heterofunctionalization of kynurenic acid derivatives. [PDF]
RSC AdvThe current study presents selective halogenation of kynurenic acid analogues and further transformation ...
Törteli L +3 more
europepmc +2 more sources
Reducing Brain Kynurenic Acid Synthesis Precludes Kynurenine-Induced Sleep Disturbances [PDF]
, 2023 Patients with neurocognitive disorders often battle sleep disturbances. Kynurenic acid is a tryptophan metabolite of the kynurenine pathway implicated in the pathology of these illnesses. Modest increases in kynurenic acid, an antagonist at glutamatergic
Christian O'Reilly +17 more
core +1 more source
Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis [PDF]
, 1996 Sustained high-level exposure to glutamate, an excitatory amino acid neurotransmitter, leads to neuronal death. Kynurenic acid attenuates the toxic effects of glutamate by inhibition of neuronal excitatory amino acid receptors, including the N-methyl-D ...
Ferriero, DM +7 more
core +2 more sources
Naphthalene-functionalized resorcinarene as selective, fluorescent self-quenching sensor for kynurenic acid† [PDF]
, 2022 Kynurenic acid is a by-product of tryptophan metabolism in humans, with abnormal levels indicative of disease. There is a need for water-soluble receptors that selectively bind kynurenic acid, allowing for detection and quantification. We report here the
Karle, Anna +17 more
core +1 more source
Measurement of kynurenine pathway metabolites by tandem mass spectrometry
Journal of Mass Spectrometry and Advances in the Clinical Lab, 2023 Objectives: Recent studies have shown that derangements in kynurenine pathway metabolite levels are associated with various pathologies such as neurodegenerative diseases, schizophrenia, depression, bipolar disorder, rheumatoid arthritis, and cancer ...
Sedat Abusoglu +4 more
doaj +1 more source
The Journal of Headache and Pain, 2021 Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs.
Eleonóra Spekker +7 more
doaj +1 more source
“Kynurenine switch” and obesity
Бюллетень сибирской медицины, 2022 Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov +9 more
doaj +1 more source
Direct determination of kynurenic acid with HPLC-MS/MS method in honey
Acta Chimica Slovenica, 2023 Kynurenic acid (KYNA) has been attributed many beneficial properties, such as antioxidant, antiproliferative, anti-inflammatory, and anti-obesogenic, as it is believed to affect metabolism and weight gain.
Anže Pavlin +2 more
doaj +1 more source
Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction
Frontiers in Endocrinology, 2023 ObjectiveSepsis is a life-threatening condition secondary to infection that evolves into a dysregulated host response and is associated with acute organ dysfunction.
Yan Cao +11 more
doaj +1 more source