Selective heterofunctionalization of kynurenic acid derivatives. [PDF]
RSC AdvThe current study presents selective halogenation of kynurenic acid analogues and further transformation thereof.
Törteli L +3 more
europepmc +6 more sources
Effects of kynurenic acid on cardiovascular system
Journal of Education, Health and Sport, 2017 Kynurenic Acid (KYNA) is an endogenous metabolite of tryptophan (TRP) which is produced by aminotransferase KAT I and KAT II in the central nervous system and peripheral tissues. Moreover it has been shown that it can be supplied with food.
Piotr Kozłowski +2 more
doaj +4 more sources
SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier
Pharmaceutics, 2021 By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through the ...
Kinga Molnár +10 more
doaj +2 more sources
Importance of Modulating Kynurenic Acid Metabolism—Approaches for the Treatment of Dementia [PDF]
BiomoleculesIn this article, we focus on kynurenic acid metabolism in neuropsychiatric disorders and the biochemical processes involved in memory and cognitive impairment, followed by different approaches in the fight against dementia.
Halina Baran +2 more
doaj +2 more sources
LifeKynurenic acid is a tryptophan (Trp) metabolite formed along the kynurenine (KYN) pathway in the brain and in peripheral tissues. The disturbed formation of kynurenic acid, which targets glutamate-mediated neurotransmission, GPR35, and aryl hydrocarbon ...
Kinga Bednarz +2 more
doaj +2 more sources
Probiotics-enhanced kynurenic acid mitigates cisplatin-induced nephrotoxicity in mice [PDF]
iScienceSummary: Cisplatin chemotherapy is limited by dose-dependent nephrotoxicity. This study investigates the nephroprotective potential of kynurenic acid (KYNA), a tryptophan metabolite, against cisplatin-induced renal injury.
Kangxin Li +8 more
doaj +2 more sources
Kynurenic acid blocks chemogenic nociception
Journal of Pharmacy and Pharmacology, 1990 Abstract Previous studies have suggested a role of excitatory amino acids (EAA) in nociception. In the present study the effects of two antagonists of EAA-receptors on capsaicin-induced eye wipings were investigated. Intracisternally administered kynurenic acid, in contrast to intravenously administered MK-801, was found to effectively ...
M, Hajós, G, Engberg
openaire +3 more sources
Synthesis of New C-3 Substituted Kynurenic Acid Derivatives
Molecules, 2020 The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as ...
Bálint Lőrinczi +3 more
doaj +3 more sources
LC-MS/MS Detection of Tryptophan, Kynurenine, Kynurenic Acid, and Quinolinic Acid in Urine Samples from Drug-Positive and Illicit Drug-Negative Patients with a Known History of Substance Use Disorder [PDF]
MetabolitesIntroduction: Currently, there are few tools for monitoring recovery in substance use disorder. As substance use has increased in prevalence, tools for measuring recovery are needed to improve therapeutic outcomes.
Lindsey Contella +8 more
doaj +2 more sources
Determination of Bioactive Compound Kynurenic Acid in Linum usitatissimum L. [PDF]
MoleculesKynurenic acid (KYNA) is a bioactive compound exhibiting multiple actions and positive effects on human health due to its antioxidant, anti-inflammatory and neuroprotective properties.
Magdalena Wróbel-Kwiatkowska +5 more
doaj +2 more sources