Results 11 to 20 of about 12,136 (185)

Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome

Frontiers in Endocrinology, 2022
BackgroundWomen with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS.
Siyu Wang, Siyu Wang, Siyu Wang, Liangshan Mu, Liangshan Mu, Chunmei Zhang, Chunmei Zhang, Xiaoyu Long, Xiaoyu Long, Yurong Zhang, Yurong Zhang, Yurong Zhang, Rong Li, Rong Li, Rong Li, Rong Li, Yue Zhao, Yue Zhao, Yue Zhao, Yue Zhao, Yue Zhao, Jie Qiao, Jie Qiao, Jie Qiao, Jie Qiao, Jie Qiao   +25 more
doaj   +1 more source

The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis

Microorganisms, 2021
In children, tick-borne encephalitis and neuroborreliosis are common infections affecting the central nervous system. As inflammatory pathways including cytokine expression are activated in these children and appear to be of importance for outcome, we ...
Ronny Wickström, Åsa Fowler, Michel Goiny, Vincent Millischer, Sofia Ygberg, Lilly Schwieler   +5 more
doaj   +1 more source

Peripheral N-methyl-d-aspartate receptor activation contributes to monosodium glutamate-induced headache but not nausea behaviours in rats

Scientific Reports, 2022
Monosodium glutamate induces behaviors thought to reflect headache and nausea in rats. We explored the effects of the N-methyl-d-aspartate receptor antagonist (2R)-amino-5-phosphonovaleric acid, the inotropic glutamate receptor antagonist kynurenic acid,
Tarique Benbow, Felisha Teja, Afrooz Sheikhi, Fernando G. Exposto, Peter Svensson, Brian E. Cairns   +5 more
doaj   +1 more source

“Kynurenine switch” and obesity

Бюллетень сибирской медицины, 2022
Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov, O. P. Shatova, M. S. Karbyshev, A. M. Gaponov, N. E. Moskaleva, S. A. Appolonova, A. V. Tutelyan, V. V. Makarov, S. M. Yudin, S. A. Roumiantsev   +9 more
doaj   +1 more source

Reactions of kynurenic acid with hypobromous acid and hypochlorous acid

Journal of Clinical Biochemistry and Nutrition, 2021
Kynurenic acid, a tryptophan metabolite, acts as antagonist or agonist of several receptors. Hypobromous acid (HOBr) and hypochlorous acid (HOCl) are generated by eosinophils and neutrophils. At inflammation sites, kynurenic acid may encounter HOBr and HOCl to generate products.
Suzuki, Toshinori, Morishita, Hiroyuki, Fukuhara, Kosumo   +2 more
openaire   +3 more sources

Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

The Journal of Headache and Pain, 2021
Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs.
Eleonóra Spekker, Klaudia Flóra Laborc, Zsuzsanna Bohár, Gábor Nagy-Grócz, Annamária Fejes-Szabó, Mónika Szűcs, László Vécsei, Árpád Párdutz   +7 more
doaj   +1 more source

Direct determination of kynurenic acid with HPLC-MS/MS method in honey

Acta Chimica Slovenica, 2023
Kynurenic acid (KYNA) has been attributed many beneficial properties, such as antioxidant, antiproliferative, anti-inflammatory, and anti-obesogenic, as it is believed to affect metabolism and weight gain.
Anže Pavlin, Matevž Pompe, Drago Kočar   +2 more
doaj   +1 more source

Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction

Frontiers in Endocrinology, 2023
ObjectiveSepsis is a life-threatening condition secondary to infection that evolves into a dysregulated host response and is associated with acute organ dysfunction.
Yan Cao, Yan Cao, Zhengyu Liu, Zhengyu Liu, Wenfeng Ma, Chen Fang, Yanfang Pei, Yingxia Jing, Jie Huang, Xiaotong Han, Xiaotong Han, Weiwei Xiao   +11 more
doaj   +1 more source

Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia

Biomolecules, 2023
Preeclampsia (PE) is a pregnancy-related disorder characterized by high blood pressure and proteinuria in the third trimester. The disease is associated with many metabolic and biochemical changes.
Zainab Abdulameer Jasim, Hussein Kadhem Al-Hakeim, Samaneh Zolghadri, Agata Stanek   +3 more
doaj   +1 more source

The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]

Medicinski Podmladak, 2023
The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš, Nikolić Tatjana, Totić-Poznanović Sanja   +2 more
doaj   +1 more source