Results 31 to 40 of about 2,520,144 (213)
The Journal of Headache and Pain, 2021 Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs.
Eleonóra Spekker +7 more
doaj +1 more source
Direct determination of kynurenic acid with HPLC-MS/MS method in honey
Acta Chimica Slovenica, 2023 Kynurenic acid (KYNA) has been attributed many beneficial properties, such as antioxidant, antiproliferative, anti-inflammatory, and anti-obesogenic, as it is believed to affect metabolism and weight gain.
Anže Pavlin +2 more
doaj +1 more source
Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction
Frontiers in Endocrinology, 2023 ObjectiveSepsis is a life-threatening condition secondary to infection that evolves into a dysregulated host response and is associated with acute organ dysfunction.
Yan Cao +11 more
doaj +1 more source
Scientific Reports, 2020 Since optimal treatment at an early stage leads to remission of symptoms and recovery of function, putative biomarkers leading to early diagnosis and prediction of therapeutic responses are desired.
Hisayuki Erabi +11 more
doaj +1 more source
Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia
Biomolecules, 2023 Preeclampsia (PE) is a pregnancy-related disorder characterized by high blood pressure and proteinuria in the third trimester. The disease is associated with many metabolic and biochemical changes.
Zainab Abdulameer Jasim +3 more
doaj +1 more source
The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]
Medicinski Podmladak, 2023 The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš +2 more
doaj +1 more source
Kynurenic Acid and Kynurenine Aminotransferase in Heart [PDF]
Pediatric Research, 1997 Kynurenic acid (KYNA) is a tryptophan metabolite and represents the only known endogenous compound acting as an antagonist to excitatory amino acid receptors in the mammalian CNS. Blocking of these receptors in CNS by KYNA affects cardiac function.
H, Baran, G, Amann, B, Lubec, G, Lubec
openaire +2 more sources
Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters. [PDF]
PLoS ONE, 2018 The mammalian kynurenine aminotransferase (KAT) enzymes are a family of related isoforms that are pyridoxal 5'-phosphate-dependent, responsible for the irreversible transamination of kynurenine to kynurenic acid.
Gayan S Jayawickrama +3 more
doaj +1 more source
The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels [PDF]
, 2023 Reductions in brain kynurenic acid levels, a neuroinhibitory metabolite, improve cognitive function in diverse organisms. Thus, modulation of kynurenic acid levels is thought to have therapeutic potential in a range of brain disorders.
Yoo, Shinja +4 more
core +1 more source
npj Breast Cancer, 2021 Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among ...
Oana A. Zeleznik +8 more
doaj +1 more source