Results 51 to 60 of about 19,595 (226)

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways [PDF]

, 2012
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines.
A Bosutti, A Jellema, A Laugeray, A Peters, A Rossi-George, A Schaffner, AA Wadee, AH Swiergiel, AJ Grossberg, AL Hassett, AL Lacerda, AM Myint, AN van den Pol, AS El-Radhi, AS Wrynn, AY Lai, B Leonard, B Owe-Larsson, BE Leonard, BE Leonard, BG Charlton, BL Hart, Brian Leonard, C Celik, C Nathan, C Song, C Song, C Song, C Song, C Song, CA Stockmeier, Cai Song, CL Raison, D Brustolim, D Wang, DK Kinney, EA Stone, ES Wohleb, F Frenois, F Kapczinski, F Moroni, G Anderson, G Werner-Felmayer, George Anderson, GM MacQueen, GR Steinberg, H Anisman, H Anisman, H Nakanishi, HC Liu, HP Kopp, I Kirsch, IK Lampe, IR Bell, J Hannestad, J Steiner, JC O'Connor, JE Bower, JE Holmes, JL Rausch, JM Twenge, KJ Jung, KJ Tracey, KS Kendler, L MacDonald, L Qin, L Toker, LE Goehler, LE Goehler, Lisa Goehler, LJ Williams, LM Harden, LV Kessing, LV Kessing, M Adib-Conquy, M Berk, M Berk, M Berk, M Berk, M Catena-Dell'Osso, M Kauer-Sant'Anna, M Koenigs, M Kubera, M Kubera, M Lyte, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, MB Hennessy, MB Howren, MC McKinnon, MC Wichers, MC Wichers, MC Wichers, MD Burton, ME Sublette, Michael Berk, Michael Maes, MJ Hoes, MJ Kluger, MJ Kluger, MJ Sharman, MP Szuba, MT Berlim, N Castanon, N Castex, NA Harrison, O Caliyurt, O Takikawa, P Gorwood, P Taepavarapruk, P Videbech, Piotr Gałecki, R Dantzer, R Medzhitov, R Roubenoff, R Yirmiya, RC Bone, RH Straub, RJ Boland, RK Jewkes, RK Kumar, RM Post, RPA Gaykema, RPA Gaykema, RPA Gaykema, RW Johnson, S Bonaccorso, S Bonaccorso, S Cunningham-Rundles, S Lacosta, S Rantala, S-M Park, SC Strijdom, SD Burdette, SE Møller, SF Maier, SM Antelman, SM Jancsár, SM O'Brien, SM Sylvén, T Hochstrasser, T Liukkonen, T Sato, T Tuma, TA Lennie, TC Olde Hartman, TM Piser, V Gabbay, WC Drevets, WS Yang, Y Dowlati, Y Huang, Y Jiang, Y Kawasaki, Y Liu, Z Pavlovićc, Z Xia   +189 more
core   +2 more sources

C–3 alkoxymethylation of 4-oxo-1,4-dihydroquinoline 2-carboxylic acid esters via organic additives

Heliyon
Esters of kynurenic acid, a known neuroprotective agent were reacted with cyclic amino acids to yield novel alkoxymethylated products under optimized reaction conditions.
Péter Simon, Bálint Lőrinczi, István Szatmári   +2 more
doaj   +1 more source

Kynurenines in the Pathogenesis of Multiple Sclerosis: Therapeutic Perspectives

Cells, 2020
Over the past years, an increasing amount of evidence has emerged in support of the kynurenine pathway’s (KP) pivotal role in the pathogenesis of several neurodegenerative, psychiatric, vascular and autoimmune diseases.
Tamás Biernacki, Dániel Sandi, Krisztina Bencsik, László Vécsei   +3 more
doaj   +1 more source

Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period

The Journal of Headache and Pain, 2021
Background Altered glutamatergic neurotransmission and neuropeptide levels play a central role in migraine pathomechanism. Previously, we confirmed that kynurenic acid, an endogenous glutamatergic antagonist, was able to decrease the expression of ...
Bernadett Tuka, Aliz Nyári, Edina Katalin Cseh, Tamás Körtési, Dániel Veréb, Ferenc Tömösi, Gábor Kecskeméti, Tamás Janáky, János Tajti, László Vécsei   +9 more
doaj   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Extending Metabolomic Studies of Apis mellifera Venom: LC-MS-Based Targeted Analysis of Organic Acids

Toxins, 2019
Organic acids are important active small molecules present in venoms and toxins, which have not been fully explored yet. The aim of the study was the determination of organic acids in honeybee venom (HBV) samples by using liquid chromatography-tandem ...
Magdalena Pawlak, Agnieszka Klupczynska, Zenon J Kokot, Jan Matysiak   +3 more
doaj   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites

EBioMedicine, 2022
Summary: Background: Neuroinflammatory diseases such as encephalitis, meningitis, multiple sclerosis and other neurological diseases with inflammatory components, have demonstrated a need for diagnostic biomarkers to define treatable and reversible ...
Jingya Yan, Velda X. Han, Benjamin Heng, Gilles J. Guillemin, Sushil Bandodkar, Russell C. Dale   +5 more
doaj   +1 more source

Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]

, 2011
The  tryptophan  metabolite,  kynurenic  acid (KYNA),  is  classically  known  to  be  an antagonist  of ionotropic glutamate receptors.
Andrew L. Varnell, Donald C. Cooper, Kevin J. Staley, Peter Dobelis   +3 more
core   +3 more sources