Results 51 to 60 of about 2,696,733 (168)

The Production of Kynurenic Acid from Tryptophane Derivatives [PDF]

, 1931
Tryptophane, when administered to certain animals, is converted into kynurenic acid. Use has been made of this fact in the study of possible cleavage of tryptophane derivatives in the alimentary tract and in the body ...
Berg, Clarence P.
core   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Body weight and mandible mechanical properties of male, control and kynurenic acid-treated, Wistar rats.

, 2019
Body weight and mandible mechanical properties of male, control and kynurenic acid-treated, Wistar rats.
Piotr Dobrowolski (2333500), Izabela Świetlicka (6069032), Jolanta Parada-Turska (8098472), Siemowit Muszyński (4112557), Janine Donaldson (8098463), Krzysztof Lamorski (8098460), Katarzyna Smolińska (682759), Maria Mielnik-Błaszczak (8098466), Ewa Tomaszewska (4112566), Piotr Paluszkiewicz (8098469), Damian Kuc (8098457)   +10 more
core   +1 more source

Kynurenine pathway dysregulation in major depressive disorder: the convergence of excitotoxicity, neuroinflammation, and oxidative stress

Journal of Neuroinflammation
Major depressive disorder (MDD) has traditionally been linked to deficient serotonergic neurotransmission, chronic stress, and heightened inflammation.
Grace O’Regan, Zoe Plummer, Brian R Christie, Sandy R Shultz, Josh Allen   +4 more
doaj   +1 more source

Does the type of exercise affect tryptophan catabolism in horses?

Animal, 2021
Tryptophan (Trp) is an essential amino acid which metabolises via the kynurenine pathway to generate a number of bioactive substances referred to as kynurenines.
W. Kędzierski, I. Sadok, S. Kowalik, I. Janczarek, M. Staniszewska   +4 more
doaj   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives

Molecules, 2020
The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as ...
Bálint Lőrinczi, Antal Csámpai, Ferenc Fülöp, István Szatmári   +3 more
doaj   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Chestnut honey - a source of kynurenic acid

U ovom radu je opisan med od kestena, njegov kemijski sastav i svojstva. Med od kestena se posebno ističe visokim sadržajem kinurenske kiseline u usporedbi s ostalim izvorima poput, ribe, rajčica i drugih prehrambenih proizvoda.
Strunje, Josip
core   +3 more sources