Results 71 to 80 of about 2,520,144 (213)

Serotonin neuromicrobiology: Psychobiotic modulation of the gut–brain axis for mental health

Ibrain, EarlyView.
An overview of Psychobiotics and Tryptophan metabolism: A serotonin‐kynurenine crosstalk shaping the Gut‐Brain axis. IDO1, Indoleamine 2,3‐dioxygenase 1; 5‐HT3, 5‐hydroxytryptamine type 3; IFN‐γ, Interferon‐gamma; TNF‐α, Tumor necrosis factor‐alpha; IL‐1β, Interleukin‐1 beta; IL‐6, Interleukin 6; Trp, Tryptophan; 5‐HT, 5‐hydroxy‐tryptamine; 5‐HTP, 5 ...
Nidhi Mandloi, Aarzoo, Chakkaravarthi Saravanan, Heera Ram, Bhim Pratap Singh   +4 more
wiley   +1 more source

Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra [PDF]

Inflammation, 2012
Kynurenic acid (KYNA) is produced enzymatically in humans and animals from kynurenine. Reports concerning changes of kynurenine metabolism during inflammation are available in the literature. Pyometra is a pathological condition characterized by the accumulation of pus in the uterine lumen and bacterial infection.
Dąbrowski, Roman, Tomasz Kocki, Szczubiał, Marek, Wojciech Dąbrowski, Jolanta Parada-Turska*   +4 more
openaire   +3 more sources

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Endogenous kynurenic acid and schizophrenia : physiological and pharmacological aspects

, 2006
Kynurenic acid is a glutamate receptor antagonist with a preferential action at the glycine/Dserine site of the N-methyl-D-aspartic acid (NMDA) receptor. The compound is a metabolite of tryptophan and is synthesized in astrocytes.
Lilly Schwieler (11149718)
core   +1 more source

Kynurenine pathway dysregulation in major depressive disorder: the convergence of excitotoxicity, neuroinflammation, and oxidative stress

Journal of Neuroinflammation
Major depressive disorder (MDD) has traditionally been linked to deficient serotonergic neurotransmission, chronic stress, and heightened inflammation.
Grace O’Regan, Zoe Plummer, Brian R Christie, Sandy R Shultz, Josh Allen   +4 more
doaj   +1 more source

Localized Controlled Release of Kynurenic Acid Encapsulated in Synthetic Polymer Reduces Implant—Induced Dermal Fibrosis

Pharmaceutics, 2022
Excessive fibrosis following surgical procedures is a challenging condition with serious consequences and no effective preventive or therapeutic option.
Layla Nabai, Aziz Ghahary, John Jackson
doaj   +1 more source

Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao, Kazuya Kawabata, Yasuaki Mizutani, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Yasuhiro Maeda, Akihiro Mouri, Hirohisa Watanabe   +8 more
wiley   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors

, 1990
Excitatory amino acid (EAA)-mediated synaptic transmission is the most prevalent excitatory system within the mammalian brain. Activation of EAA receptors has been postulated to contribute to neuronal cell death in stroke, epilepsy, hypoglycemia, and ...
MF Beal, A Freese, MJ During, KJ Swartz
core   +1 more source

Similarity Between the Action of Pteridines and Tryptophan Metabolites on Lipid Metabolism

Pteridines, 1999
Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate, Krebs-Ringer-phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol. The addition of anthranilic acid (2.2 and
Rudzite Vera, Jurika Edite, Widner Bernhard, Fuchs Dietmar   +3 more
doaj   +1 more source