Results 71 to 80 of about 12,136 (185)

SLC7A5 promotes colorectal cancer liver metastasis by reprogramming tryptophan metabolism through the Kyn/XANA‒AhR axis and reshaping the immune microenvironment

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
SLC7A5‒Kyn/XANA signalling activates AhR to drive EMT and metastatsis. SLC7A5 knockdown enhances macrophage antigen presentation and reverses CD8+ T‐cell exhaustion. SLC7A5 knockdown induces antigen‐driven and IgG‐secreting B‐cell clonal expansion. Combination of SLC7A5 inhibition and anti‐PD‐1 therapy offers clinical targeting.
Yaohao Luo, Lei Li, Shanbao Li, Xinshuai Wang, Zeping He, Fangbin Song, Jun Qin, Jinyan Zhang, Junming Xu   +8 more
wiley   +1 more source

Cytotoxic Effects of Kynurenic Acid and Quinaldic Acid in Hepatocellular Carcinoma (HepG2) Cell Line

Proceedings, 2017
Kynurenic acid (KYNA), tryptophan metabolite synthesized in the kynurenine pathway, is present in human body fluids as well as in variety of foods, herbal medicines and honeybee derived foodstuffs.
Pınar Atalay Dündar, N. Nalan İmamoğlu   +1 more
doaj   +1 more source

Indole‐3‐Propionic Acid Alleviates Metabolic Dysfunction‐Associated Fatty Liver Disease via AHR/AMPK Signaling Activation

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
IPA promotes AHR nuclear translocation and AMPK phosphorylation. Phosphorylated AMPK may in turn facilitate AHR translocation, suggesting a potential reciprocal interplay that contributes to alleviating hepatic lipid deposition in MAFLD. ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD) is a health problem worthy of attention ...
Yanting Huang, Meimei Yu, Jiaxin Lu, Chujun Lin, Shuhuan Li, Yalin Chen, Xin Chen, Hongliang Xue, Jing Chen, Lijie Su   +9 more
wiley   +1 more source

Female Mice Show Stronger Time‐of‐Day Modulation of Astrocytic Ca2+ Activity in the Sleep‐Regulatory Ventrolateral Preoptic Nucleus

Glia, Volume 74, Issue 8, August 2026.
VLPO astrocytes exhibit sex‐specific Ca2+ dynamics across the nycthemeral cycle. Males show faster Ca2+ kinetics, while females display increased amplitude, frequency, and network coupling at Zeitgeber Time (ZT)‐14. Sex is a key variable in astrocyte‐based sleep regulation mechanisms.
Félix Camille Bellier, Lou Zonca, David Holcman, Frédéric Chauveau, Nathalie Rouach, Armelle Rancillac   +5 more
wiley   +1 more source

Physicochemical Characterization of Kynurenine Pathway Metabolites

Antioxidants
The kynurenine pathway is a significant metabolic route involved in the catabolism of tryptophan, producing various bioactive metabolites with crucial roles as antioxidants in immune regulation and neurobiology.
Luca Buzásy, Károly Mazák, Balázs Balogh, Balázs Simon, Anna Vincze, György Tibor Balogh, Tamás Pálla, Arash Mirzahosseini   +7 more
doaj   +1 more source

Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older‐Age Bipolar Disorder ISBD Task Forces

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders, Sigfried N. T. M. Schouws, Andrew T. Olagunju, Vicent Balanzá‐Martínez, Nicole C. M. Korten, Ralph W. Kupka, Katherine E. Burdick, Andre F. Carvalho, Ariel G. Gildengers, Lars V. Kessing, Roger S. McIntyre, Paula V. Nunes, Ayal Schaffer, Ivan J. Torres, Shang‐Ying Tsai, Tamsyn E. Van Rheenen, Eduard Vieta, Lakshmi N. Yatham, Allan H. Young, Lisa T. Eyler, Kamilla W. Miskowiak, Annemiek Dols   +21 more
wiley   +1 more source

Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s disease

npj Parkinson's Disease
We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson’s disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD (“OFF”), 86 controls); CSF ...
Leslie C. Jellen, Martha L. Escobar Galvis, Qiong Sha, Christine Isaguirre, Amy Johnson, Zach Madaj, Mechelle M. Lewis, Ryan D. Sheldon, Lan Kong, Xuemei Huang, Lena Brundin   +10 more
doaj   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, Volume 293, Issue 15, Page 4533-4553, August 2026.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Physiological mechanisms and therapeutic targets in chronic cough

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited.
James C. Brown, Katherine L. Rhatigan, Oliver J. Price, Peter S. P. Cho   +3 more
wiley   +1 more source

Lactobacillus regulate muscle fiber type conversion in Chinese native pigs via tryptophan metabolism

npj Biofilms and Microbiomes
Identifying potential gut microbes and metabolites that can influence muscle fiber type is gaining interest in meat quality research. In this study, muscle fiber characteristics, muscle metabolite profiles, and gut microbiota and metabolome were compared
Bo Song, Md. Abul Kalam Azad, Qian Zhu, Yating Cheng, Sujuan Ding, Kang Yao, Xiangfeng Kong   +6 more
doaj   +1 more source