Results 71 to 80 of about 2,696,733 (168)

A history of suicide attempts among individuals with schizophrenia is associated with tryptophan degradation via the salivary kynurenine pathway

BMC Psychiatry
Background Tryptophan, an essential precursor metabolite within the kynurenine pathway, has been implicated in the neurobiological mechanisms underlying both schizophrenia and associated suicidality. Despite this link, the lack of validated biomarkers to
Yi Yin, Ting Xie, Jinghui Tong, Junchao Huang, Baopeng Tian, Mengzhuang Gou, Song Chen, Shuping Tan, Zhiren Wang, Yongsheng Tong, Yanfang Zhou, Leilei Wang, Yunlong Tan   +12 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, Volume 600, Issue 19, Page 2876-2898, October 2026.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion [PDF]

, 2015
The trigeminal ganglion (TG) plays a central role in cranial pain. Administration of complete Freund's adjuvant (CFA) into the temporomandibular joint (TMJ) elicits activation of TG.
Toldi József, F. Fülöp, Edvinsson, Lars,, Fülöp Ferenc, Vécsei, L, L. Edvinsson, Csáti, A, J. Tajti, Csáti Anett, Tajti János, Edvinsson, Lars, Vécsei László, Edvinsson Lars, Toldi, J, Warfvinge, Karin,, L. Vécsei, K. Warfvinge, Warfvinge, Karin, Tajti, J, Warfvinge Karin, Fülöp, F, Lund University., A. Csáti, J. Toldi   +23 more
core   +2 more sources

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, Volume 13, Issue 55, 5 October 2026.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease

Journal of Neuroinflammation, 2019
Background Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer’s disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in ...
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins   +17 more
doaj   +1 more source

Cytotoxic Effects of Kynurenic Acid and Quinaldic Acid in Hepatocellular Carcinoma (HepG2) Cell Line

Proceedings, 2017
Kynurenic acid (KYNA), tryptophan metabolite synthesized in the kynurenine pathway, is present in human body fluids as well as in variety of foods, herbal medicines and honeybee derived foodstuffs.
Pınar Atalay Dündar, N. Nalan İmamoğlu   +1 more
doaj   +1 more source

HPLC-ESI-MS and GC-EI-MS Identification and Quantitation of Polyphenolics and Alkaloids in Moroccan Jujube Honeys

Journal of Apicultural Science, 2020
The aim of this study was to determine the phytochemical content of Moroccan Jujube Honey and to establish the principal components of this staple Moroccan food, which contributes health benefit for the local population.
Khallouki Farid, Akdad Mourad, Bouddine Toufik, Hajji Lhoussain, Owen Robert W.   +4 more
doaj   +1 more source

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles, Schwarz, J.M., Berfelo, M. W., M. Schwarz, Vles, J. S. H., Schwarz, M., Hulsman, J. A. R. J., A. Myint, Majoie, H. J. M., M.W. Berfelo, Hulsman, J.A.R.J., K. Rijkers, Myint, A., J.A.R.J. Hulsman, Rijkers, K., H.J.M. Majoie   +15 more
core   +1 more source

Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review

Journal of Neuroinflammation, 2020
Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi, Osama Elyamany, Christoph Rummel, Christoph Mulert   +3 more
doaj   +1 more source

Kynurenic acid levels are elevated in the cerebrospinal fluid of patientswith schizophrenia

, 2001
Kynurenic acid is an endogenous glutamate antagonist with a preferential action at the glycine-site of the N-methyl d-aspartate-receptor. Mounting evidence indicate that the compound is significantly involved in basal neurophysiological processes in the ...
Lindström, Leif H.,, Engberg, G, Nordin, C, Skogh, E, Erhardt, S, Blennow, K, Skogh, Elisabeth,, Engberg, G,, Lindström, LH, Erhardt, Sophie, Engberg, Göran, Nordin, Conny,, Erhardt, S,, Lindström, Leif, Blennow, Kaj   +14 more
core   +1 more source