Results 91 to 100 of about 2,696,733 (168)

Endogenous kynurenic acid and schizophrenia : physiological and pharmacological aspects

, 2006
Kynurenic acid is a glutamate receptor antagonist with a preferential action at the glycine/Dserine site of the N-methyl-D-aspartic acid (NMDA) receptor. The compound is a metabolite of tryptophan and is synthesized in astrocytes.
Lilly Schwieler (11149718)
core   +1 more source

Densitometric parameters, trabecular bone morphometry and geometric parameters of the mandible of female, control and kynurenic acid-treated, Wistar rats.

, 2019
Densitometric parameters, trabecular bone morphometry and geometric parameters of the mandible of female, control and kynurenic acid-treated, Wistar rats.
Piotr Dobrowolski (2333500), Izabela Świetlicka (6069032), Jolanta Parada-Turska (8098472), Siemowit Muszyński (4112557), Janine Donaldson (8098463), Krzysztof Lamorski (8098460), Katarzyna Smolińska (682759), Maria Mielnik-Błaszczak (8098466), Ewa Tomaszewska (4112566), Piotr Paluszkiewicz (8098469), Damian Kuc (8098457)   +10 more
core   +1 more source

Densitometric parameters, trabecular bone morphometry and geometric parameters of the mandible of male, control and kynurenic acid-treated, Wistar rats.

, 2019
Densitometric parameters, trabecular bone morphometry and geometric parameters of the mandible of male, control and kynurenic acid-treated, Wistar rats.
Piotr Dobrowolski (2333500), Izabela Świetlicka (6069032), Jolanta Parada-Turska (8098472), Siemowit Muszyński (4112557), Janine Donaldson (8098463), Krzysztof Lamorski (8098460), Katarzyna Smolińska (682759), Maria Mielnik-Błaszczak (8098466), Ewa Tomaszewska (4112566), Piotr Paluszkiewicz (8098469), Damian Kuc (8098457)   +10 more
core   +1 more source

Tryptophan metabolites clearance in hemodialyzed patients

Amino Acids
Hemodialysis (HD) and hemodiafiltration (HDF) procedures have limited efficacy regarding removal of selected toxins. Tryptophan (Trp) metabolites formed through the kynurenine (KYN) pathway are known to contribute to kidney failure (KF) complications ...
Izabela Zakrocka, Radosław Mlak, Natalia Moniczewska, Sylwia Boczkowska, Renata Kloc, Tomasz Kocki, Ewa M. Urbańska, Wojciech Załuska, Andreas Kronbichler   +8 more
doaj   +1 more source

High concentration of kynurenic acid in bile and pancreatic juice

, 2009
Kynurenic acid (KYNA) is an agonist of the G-protein-coupled receptor GPR35, which is predominantly expressed in gastrointestinal tissues. The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and ...
Schabowski, Janusz, Pierzynowski, Stefan, Saran, Tomasz, Zgrajka, Wojciech, Turski, Waldemar A., Pierzynowski, Stefan,, Paluszkiewicz, Piotr, Piedra, Jose L. Valverde, Fedkiv, Olexandr, Rengman, Sofia, Fedkiv, Olexandr,   +10 more
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Lactobacillus reuteri DSM 17938 and Its Supernatant Ameliorate Parkinson’s Disease in Association with Modulation of Gut Microbiota and Its Tryptophan Metabolism

Antioxidants
Parkinson’s disease (PD) is a neurodegenerative disorder associated with gut dysbiosis and tryptophan metabolism disturbance, but the mechanisms of probiotic action are unclear.
Bin Su, Fanying Meng, Yao Lu, Yunlong Zhang, Tingting Wang, Yuxin Zhang, Jiajia Liu, Lianbing Lin   +7 more
doaj   +1 more source

Memantine increases brain production of kynurenic acid via protein kinase A-dependent mechanism

, 2008
We describe a novel aspect of action of memantine ex vivo, in the brain cortical slices and in vitro, in mixed glial cultures. The drug potently increased the production of kynurenic acid, an endogenous tryptophan metabolite blocking N-methyl-D-aspartate
Kloc, R, Luchowska, E, Owe-Larsson, B,, Wielosz, M, Urbanska, EM   +4 more
core   +1 more source

Exploring Protein-Ligand Interactions to Increase the Binding Action of Kynurenic Acid to GPR35

The g-protein coupled receptor 35, or GPR35, is the receptor responsible for the initiation of the chemokine-mediated signaling pathway in humans, expressed primarily in the duodenum and small intestine.
Harbison, April
core  

Glutamatergic mechanisms in schizophrenia : role of endogenous kynurenic acid

, 2005
Kynurenic acid, a tryptohan metabolite synthesised in astrocytes, is an endogenous antagonist at glutamate receptors, in particular it blocks the glycine site of the (NMDA)-receptor, and at the a7* nicotinic receptor.
Linda K Nilsson (19490326)
core  

Kynurenic acid synthesis by human glioma

, 1990
Udgivelsesdato: 1990-OctBiopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an ...
Schwarcz, R, Gramsbergen, J B, Vezzani, A, Stasi, M A, Procaccio, F, Versari, P   +5 more
core   +1 more source