Results 91 to 100 of about 19,359 (226)
Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Advanced Science, Volume 13, Issue 19, 2 April 2026.Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang +17 more
wiley +1 more source
Immune–proteo–metabolomic changes link to Aβ and tau pathology in Alzheimer disease
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION Tryptophan metabolism is increasingly implicated in Alzheimer's disease (AD), particularly through aryl hydrocarbon receptor (AhR) ligands that influence neuroinflammation. However, their relationships with core AD pathology—amyloid‐β (A) and tau (T) deposition—and associated immune–proteomic alterations remain unclear. METHODS We
Meng Wang +21 more
wiley +1 more source
Kynurenine pathway metabolism and the microbiota-gut-brain axis [PDF]
, 2018 It has become increasingly clear that the gut microbiota influences not only gastrointestinal physiology but also central nervous system (CNS) function by modulating signalling pathways of the microbiota-gut-brain axis.
Clarke, Gerard +3 more
core +1 more source
Journal of Neuroinflammation, 2019 Background Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer’s disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in ...
Pratishtha Chatterjee +17 more
doaj +1 more source
Biotechnology Journal, Volume 21, Issue 4, April 2026.Graphical Abstract and Lay Summary We characterize the gut microbiota signatures associated with Thalidomide treatment in small cell lung cancer patients experiencing chemotherapy‐induced nausea and vomiting. The analysis reveals significant changes in specific genera, linking microbial composition to symptom management. ABSTRACT Small cell lung cancer
Qiang‐Guo Sun +5 more
wiley +1 more source
Substance P-Driven Feed-Forward Inhibitory Activity in the Mammalian Spinal Cord [PDF]
, 2005 In mammals, somatosensory input activates feedback and feed-forward inhibitory circuits within the spinal cord dorsal horn to modulate sensory processing and thereby affecting sensory perception by the brain.
Terumasa Nakatsuka +9 more
core +1 more source
Cytotoxic Effects of Kynurenic Acid and Quinaldic Acid in Hepatocellular Carcinoma (HepG2) Cell Line
Proceedings, 2017 Kynurenic acid (KYNA), tryptophan metabolite synthesized in the kynurenine pathway, is present in human body fluids as well as in variety of foods, herbal medicines and honeybee derived foodstuffs.
Pınar Atalay Dündar +1 more
doaj +1 more source
Journal of Apicultural Science, 2020 The aim of this study was to determine the phytochemical content of Moroccan Jujube Honey and to establish the principal components of this staple Moroccan food, which contributes health benefit for the local population.
Khallouki Farid +4 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Health impacts of honey. ABSTRACT Honey is a natural and nutritious product of the honey bee (Apis mellifera) with low water content. Its color ranges from white to amber, with taste varying accordingly. The chemical form and viscosity of honey depend on its composition.
Ecem Bolat +7 more
wiley +1 more source
Glutamate and opioid antagonists modulate dopamine levels evoked by innately attractive male chemosignals in the nucleus accumbens of female rats [PDF]
, 2017 Sexual chemosignals detected by vomeronasal and olfactory systems mediate intersexual attraction in rodents, and act as a natural reinforcer to them.
Agustín-Pavón, Carmen +8 more
core +2 more sources