Results 91 to 100 of about 2,520,144 (213)

Role of kynurenic acid in Alzheimer disease

, 2014
Die Alzheimer-Erkrankung ist eine neurodegenerative Demenzerkrankung, für die bisher keine kurative Therapie entwickelt werden konnte. Im Jahr 2007 lag die weltweite Prävalenz bei 29 Millionen (Brookmeyer et al. 2007).
Steiner, Levke
core   +1 more source

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease

Journal of Neuroinflammation, 2019
Background Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer’s disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in ...
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins   +17 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, Volume 16, Issue 9, Page 1645-1656, September 2026.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

HPLC-ESI-MS and GC-EI-MS Identification and Quantitation of Polyphenolics and Alkaloids in Moroccan Jujube Honeys

Journal of Apicultural Science, 2020
The aim of this study was to determine the phytochemical content of Moroccan Jujube Honey and to establish the principal components of this staple Moroccan food, which contributes health benefit for the local population.
Khallouki Farid, Akdad Mourad, Bouddine Toufik, Hajji Lhoussain, Owen Robert W.   +4 more
doaj   +1 more source

Music and Exercise in Concert: Uncovering Synergistic Mechanisms for Enhancing Brain Health and Cognitive Resilience—A Narrative Review

Brain and Behavior, Volume 16, Issue 9, September 2026.
Music and physical exercise share convergent neurobiological mechanisms, including neuroplasticity, metabolic regulation, and neuroinflammatory modulation. Integrating music with exercise produces synergistic effects that enhance brain function beyond single interventions.
Sanxia Yang, Qingluan Liu, Minghui Wang, Yidan Zhang   +3 more
wiley   +1 more source

Metabolomics and Mechanistic Approaches Reveal the Synergistic and Attenuating of Rubus chingii Hu on Tripterygium Glycoside Tablets in the Treatment of Rheumatoid Arthritis

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Experimental flow chart of the attenuating and synergistic effects of RCH on TGTs in the treatment of rheumatoid arthritis. ABSTRACT Tripterygium Glycoside Tablets (TGTs) are primary drugs for rheumatoid arthritis (RA) but pose a risk of nephrotoxicity. Rubus chingii Hu (RCH) may enhance kidney function.
Cong Zhang, Zepeng Zhang, Fang Yan, Lei Zhang   +3 more
wiley   +1 more source

The Molecular Architecture of Somatic Spines of the Lateral Septum

Journal of Comparative Neurology, Volume 534, Issue 9, September 2026.
Spine synapses represent stable synaptic connections that allow neurons to chemically communicate with each other. Although known for decades, the unusual spine synapses found directly on neuronal cell bodies in the lateral septum have not been characterised in detail.
Daniela Hacker, Erich Weisheim, Michaela Schweizer, Undine Schneeweiß, Maximilian Borgmeyer, Michael Brecht, Marina Mikhaylova   +6 more
wiley   +1 more source

Glutamatergic mechanisms in schizophrenia : role of endogenous kynurenic acid

, 2005
Kynurenic acid, a tryptohan metabolite synthesised in astrocytes, is an endogenous antagonist at glutamate receptors, in particular it blocks the glycine site of the (NMDA)-receptor, and at the a7* nicotinic receptor.
Linda K Nilsson (19490326)
core   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source

Psilocybin, From Ancestral Use to Therapeutic Potential: A Multidimensional Review of Its Pharmacological Basis and Current Perspectives

Human Psychopharmacology: Clinical and Experimental, Volume 41, Issue 5, September 2026.
ABSTRACT Objective This review critically examines psilocybin, with particular emphasis on its pharmacokinetics and pharmacodynamics, including its serotonergic, neuroplastic, and anti‐inflammatory mechanisms. It integrates historical context, preclinical and clinical evidence, and evaluates emerging therapeutic potential, safety, microdosing practices,
José Norberto Vásquez‐Bonilla
wiley   +1 more source