Results 111 to 120 of about 19,595 (226)

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 [PDF]

, 2017
Medium chain fatty acids can activate the pro-inflammatory receptor GPR84 but so also can molecules related to 3,3′-diindolylmethane. 3,3′-Diindolylmethane and decanoic acid acted as strong positive allosteric modulators of the function of each other and
De Vos, Steve, Gosmini, Romain, Hudson, Brian D., Jenkins, Laura, Labéguère, Frédéric, Mahmud, Zobaer Al, Milligan, Graeme, Tikhonova, Irina G., Ulven, Trond   +8 more
core   +3 more sources

Lactobacillus regulate muscle fiber type conversion in Chinese native pigs via tryptophan metabolism

npj Biofilms and Microbiomes
Identifying potential gut microbes and metabolites that can influence muscle fiber type is gaining interest in meat quality research. In this study, muscle fiber characteristics, muscle metabolite profiles, and gut microbiota and metabolome were compared
Bo Song, Md. Abul Kalam Azad, Qian Zhu, Yating Cheng, Sujuan Ding, Kang Yao, Xiangfeng Kong   +6 more
doaj   +1 more source

Losartan Reverses Hippocampal Increase of Kynurenic Acid in Type 1 Diabetic Rats: A Novel Procognitive Aspect of Sartan Action

Journal of Diabetes Research, 2019
Patients with diabetes mellitus (DM) type 1 and 2 are at a higher risk of cognitive decline and dementia; however, the underlying pathology is poorly understood.
Iwona Chmiel-Perzyńska, Adam Perzyński, Bartosz Olajossy, Paulina Gil-Kulik, Janusz Kocki, Ewa M. Urbańska   +5 more
doaj   +1 more source

Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors [PDF]

, 2011
Hippocampal CA1 pyramidal neurons are highly sensitive to ischemic damage, whereas neighboring CA3 pyramidal neurons are less susceptible. It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia,
Cimarosti, Helena, Dennis, Siobhan, Hanley, Jonathan G., Henley, Jeremy M., Jaafari, Nadia, Mellor, Jack R.   +5 more
core   +1 more source

Activation of nociception‐sensitive ionotropic glutamate receptor‐expressing rostroventrolateral medulla neurons by stimulation of cardiac afferents in rats

FASEB BioAdvances
Myocardial ischemia causes the release of bradykinin, which activates afferent nerve endings in the ventricular epicardium. This elicits a sympathetically mediated increase in arterial pressure and heart rate, referred to as the cardiogenic sympathetic ...
Matthew R. Zahner, Cade C. Oculam, Eric Beaumont   +2 more
doaj   +1 more source

Novel Regulation of Cortical Acetylcholine Release and Cognitive Behavior [PDF]

, 2008
SBS Undergraduate Research GrantASC Undergraduate Research Scholarship CompetitionDean's Undergraduate Research FundABSTRACT There is an evolving literature demonstrating the ability of non-neuronal cells to regulate the release of traditional ...
Gardner, Kristen
core  

Regulation of prefrontal glutamate by the endogenous neuromodulator kynurenic acid as measured by rapid electrochemistry: relevance to schizophrenia [PDF]

, 2010
Schizophrenia is one of the most debilitating neuropsychiatric disorders, with a prevalence of approximately 1% worldwide. Symptoms include impairing deficits in cognitive processes (e.g., working memory, attention, and cognitive flexibility) which are ...
Campbell, Andrew
core  

Tryptophan metabolites clearance in hemodialyzed patients

Amino Acids
Hemodialysis (HD) and hemodiafiltration (HDF) procedures have limited efficacy regarding removal of selected toxins. Tryptophan (Trp) metabolites formed through the kynurenine (KYN) pathway are known to contribute to kidney failure (KF) complications ...
Izabela Zakrocka, Radosław Mlak, Natalia Moniczewska, Sylwia Boczkowska, Renata Kloc, Tomasz Kocki, Ewa M. Urbańska, Wojciech Załuska, Andreas Kronbichler   +8 more
doaj   +1 more source

Feeding Experiments with Kynurenic Acid [PDF]

Biochemical Journal, 1916
openaire   +2 more sources

The Metabolism of Kynurenic Acid

Journal of Biological Chemistry, 1961
Kengo Horibata, Hiroshi Taniuchi, Minoru Tashiro, Sigeru Kuno, Osamu Hayaishi   +4 more
openaire   +1 more source