Results 111 to 120 of about 2,520,144 (213)

Kynurenic acid in psychiatric disorders : studies on the mechanisms of action

, 2010
Kynurenic acid, a metabolite of tryptophan along the kynurenine pathway, is an endogenous antagonist at NMDA- and α7* nicotinic acetylcholine- (α7*nACh) receptors.
Klas Linderholm (19526311)
core   +1 more source

Endogenous kynurenic acid and schizophrenia : physiological and pharmacological aspects [Elektronisk resurs]

, 2006
Kynurenic acid is a glutamate receptor antagonist with a preferential action at the glycine/Dserine site of the N-methyl-D-aspartic acid (NMDA) receptor. The compound is a metabolite of tryptophan and is synthesized in astrocytes.
Schwieler, L,
core  

Kynurenic acid and its analogues

Journal of Medical Pharmaceutical and Allied Sciences
Tryptophan serves as a rate-limiting essential amino acid and a distinctive building block of peptides and proteins. Many immune system cells are known to be regulated by tryptophan metabolites. Kynurenic acid, an endogenous byproduct of tryptophan metabolism, functions as a wide-spectrum inhibitor of excitatory amino acid receptors and may serve as a ...
openaire   +1 more source

Importance of endogenous kynurenic acid in brainm catecholaminergic processes and in the pathophysiology of schizophrenia

, 2001
Kynurenic acid is a metabolite of tryptophan and the only known naturally occurring NMethylD-Aspartic acid (NMDA)-receptor antagonist (at the co-agonist glycine site) in the human brain.The aim of the present work was to investigate the physiological and
Sophie Erhardt (8939066)
core   +1 more source

Exploring Protein-Ligand Interactions to Increase the Binding Action of Kynurenic Acid to GPR35

The g-protein coupled receptor 35, or GPR35, is the receptor responsible for the initiation of the chemokine-mediated signaling pathway in humans, expressed primarily in the duodenum and small intestine.
Harbison, April
core  

<i>GRIA3</i>: proposal for a neuroimmune role linking infection, stress, chronic disorders and the activity of kynurenic acid. [PDF]

Front Cell Neurosci
Stone TW, Clanchy FIL, Williams RO.
europepmc   +1 more source

THE CONSTITUTION OF KYNURENIC ACID

Journal of Biological Chemistry, 1914
openaire   +1 more source

Kynurenic acid mediates epicardial fat-induced lymphatic metabolic dysfunction in atrial fibrillation. [PDF]

Nat Commun
Takahashi M, Abe I, Yoshida N, Katoh D, Fujita D, Goto S, Yamasaki H, Ko T, Jiang Y, He Y, Ito S, Harada T, Takano M, Sato H, Kondo H, Fukui A, Teshima Y, Sako H, Ohta K, Miyamoto S, Yamauchi T, Nomura S, Takeda N, Komuro I, Takahashi N.   +24 more
europepmc   +1 more source

Astroglial disinhibition of cortical circuits disrupts cognition via kynurenic acid in mice. [PDF]

Nat Commun
Beilmann V, Furrer J, Schalbetter SM, Schaer R, Tiziani E, Ferrari KD, Herrero F, Heeb C, von Faber-Castell A, Condrau J, Weber-Stadlbauer U, Wyss MT, Saab AS, Beggiato S, Meyer U, Weber B, Notter T.   +16 more
europepmc   +1 more source

Biochemical Regulation of Brain Kynurenic Acid Synthesis and Inhibition in Rats Is Sensitive to the Time of Day. [PDF]

ACS Chem Neurosci
Wright CJ, Buck SA, Milosavljevic S, Lewis AM, Wagner NTJ, Pocivavsek A.   +5 more
europepmc   +1 more source