Results 101 to 110 of about 2,520,144 (213)
Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang +10 more
wiley +1 more source
Metabolic Syndrome: From Mechanisms to Therapeutic Interventions
MedComm, Volume 7, Issue 9, September 2026.A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 18, Page 5458-5475, September 2026.Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle +12 more
wiley +1 more source
Kynurenic acid levels are elevated in the cerebrospinal fluid of patientswith schizophrenia
, 2001 Kynurenic acid is an endogenous glutamate antagonist with a preferential action at the glycine-site of the N-methyl d-aspartate-receptor. Mounting evidence indicate that the compound is significantly involved in basal neurophysiological processes in the ...
Lindström, Leif H., +5 more
core +1 more source
The Production of Kynurenic Acid from Tryptophane and Indole Derivatives [PDF]
, 1934 The production of kynurenic acid from derivatives closely related to tryptophane serves as a means of indicating whether the animal organism is able to accomplish the changes necessary to convert such derivatives into tryptophane itself, or into some ...
Bauguess, Lyle C., Berg, Clarence P.
core +1 more source
The Journal of Physiology, Volume 604, Issue 17, Page 7313-7336, 1 September 2026.Abstract figure legend Prader‐Willi syndrome (PWS) originates from deficiencies in chromosome 15q11‐13 region clustering around a critical region containing multiple‐repeat non‐coding RNA gene Snord116, resulting in metabolic and behavioural abnormalities leading to hyperphagia and obesity.
Volodymyr Rybalchenko, Ryan Butler
wiley +1 more source
Oestrogen modulates stress‐induced vagally‐dependent gastric responses to oxytocin
The Journal of Physiology, Volume 604, Issue 18, Page 7570-7593, 15 September 2026.Abstract figure legend In female rats, PVNCRF‐DMV neurons and DMV CRF1 receptors are tonically active, allowing oxytocin (OXT) to modulate inhibitory GABAergic transmission to DMV neurons. Parasympathetic control of gastric functions involves engagement of non‐adrenergic non‐cholinergic vagal efferent pathways, but recruitment of distinct pathways ...
Ruchi Bhagat +2 more
wiley +1 more source
Kynurenic acid in psychiatric disorders : studies on the mechanisms of action [Elektronisk resurs]
, 2010 Kynurenic acid, a metabolite of tryptophan along the kynurenine pathway, is an endogenous antagonist at NMDA- and α7* nicotinic acetylcholine- (α7*nACh) receptors.
Linderholm, K,
core
Glutamatergic mechanisms in schizophrenia : role of endogenous kynurenic acid [Elektronisk resurs]
, 2005 Kynurenic acid, a tryptohan metabolite synthesised in astrocytes, is an endogenous antagonist at glutamate receptors, in particular it blocks the glycine site of the (NMDA)-receptor, and at the a7* nicotinic receptor.
Nilsson, LK,
core
, 2011 Kynurenic acid is an astrocyte-derived tryptophan metabolite and a marker of neuroinflammation that antagonizes N-metyl-D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors in the brain.
Olsson, S
core