Results 81 to 90 of about 12,136 (185)

Losartan Reverses Hippocampal Increase of Kynurenic Acid in Type 1 Diabetic Rats: A Novel Procognitive Aspect of Sartan Action

Journal of Diabetes Research, 2019
Patients with diabetes mellitus (DM) type 1 and 2 are at a higher risk of cognitive decline and dementia; however, the underlying pathology is poorly understood.
Iwona Chmiel-Perzyńska, Adam Perzyński, Bartosz Olajossy, Paulina Gil-Kulik, Janusz Kocki, Ewa M. Urbańska   +5 more
doaj   +1 more source

Activation of nociception‐sensitive ionotropic glutamate receptor‐expressing rostroventrolateral medulla neurons by stimulation of cardiac afferents in rats

FASEB BioAdvances
Myocardial ischemia causes the release of bradykinin, which activates afferent nerve endings in the ventricular epicardium. This elicits a sympathetically mediated increase in arterial pressure and heart rate, referred to as the cardiogenic sympathetic ...
Matthew R. Zahner, Cade C. Oculam, Eric Beaumont   +2 more
doaj   +1 more source

Tryptophan metabolites clearance in hemodialyzed patients

Amino Acids
Hemodialysis (HD) and hemodiafiltration (HDF) procedures have limited efficacy regarding removal of selected toxins. Tryptophan (Trp) metabolites formed through the kynurenine (KYN) pathway are known to contribute to kidney failure (KF) complications ...
Izabela Zakrocka, Radosław Mlak, Natalia Moniczewska, Sylwia Boczkowska, Renata Kloc, Tomasz Kocki, Ewa M. Urbańska, Wojciech Załuska, Andreas Kronbichler   +8 more
doaj   +1 more source

Lactobacillus reuteri DSM 17938 and Its Supernatant Ameliorate Parkinson’s Disease in Association with Modulation of Gut Microbiota and Its Tryptophan Metabolism

Antioxidants
Parkinson’s disease (PD) is a neurodegenerative disorder associated with gut dysbiosis and tryptophan metabolism disturbance, but the mechanisms of probiotic action are unclear.
Bin Su, Fanying Meng, Yao Lu, Yunlong Zhang, Tingting Wang, Yuxin Zhang, Jiajia Liu, Lianbing Lin   +7 more
doaj   +1 more source

Feeding Experiments with Kynurenic Acid [PDF]

Biochemical Journal, 1916
openaire   +2 more sources

The Metabolism of Kynurenic Acid

Journal of Biological Chemistry, 1961
Kengo Horibata, Hiroshi Taniuchi, Minoru Tashiro, Sigeru Kuno, Osamu Hayaishi   +4 more
openaire   +1 more source

Kynurenic acid and its analogues

Journal of Medical Pharmaceutical and Allied Sciences
Tryptophan serves as a rate-limiting essential amino acid and a distinctive building block of peptides and proteins. Many immune system cells are known to be regulated by tryptophan metabolites. Kynurenic acid, an endogenous byproduct of tryptophan metabolism, functions as a wide-spectrum inhibitor of excitatory amino acid receptors and may serve as a ...
openaire   +1 more source

Biochemical Regulation of Brain Kynurenic Acid Synthesis and Inhibition in Rats Is Sensitive to the Time of Day. [PDF]

ACS Chem Neurosci
Wright CJ, Buck SA, Milosavljevic S, Lewis AM, Wagner NTJ, Pocivavsek A.   +5 more
europepmc   +1 more source

Biochemical and Pharmacological Studies on Kynurenic Acid Metabolism in the <i>Helix pomatia</i>-Snail Model of Learning and Memory. [PDF]

Biomolecules
Baran H, Kronsteiner C.
europepmc   +1 more source

Activation of the Ahr-IL-6 Axis by Kynurenic Acid Promotes Bone Marrow-Derived MSC Expansion. [PDF]

Curr Issues Mol Biol
Nguyen CH, Hoang HTT, Vu TT, Pham AD, Tran TT, Nakahama T, Nguyen NT.   +6 more
europepmc   +1 more source