Results 81 to 90 of about 2,696,733 (168)

Physicochemical Characterization of Kynurenine Pathway Metabolites

Antioxidants
The kynurenine pathway is a significant metabolic route involved in the catabolism of tryptophan, producing various bioactive metabolites with crucial roles as antioxidants in immune regulation and neurobiology.
Luca Buzásy, Károly Mazák, Balázs Balogh, Balázs Simon, Anna Vincze, György Tibor Balogh, Tamás Pálla, Arash Mirzahosseini   +7 more
doaj   +1 more source

Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s disease

npj Parkinson's Disease
We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson’s disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD (“OFF”), 86 controls); CSF ...
Leslie C. Jellen, Martha L. Escobar Galvis, Qiong Sha, Christine Isaguirre, Amy Johnson, Zach Madaj, Mechelle M. Lewis, Ryan D. Sheldon, Lan Kong, Xuemei Huang, Lena Brundin   +10 more
doaj   +1 more source

Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice

, 2020
Study investigated the role of the neuroprotective kynurenic acid (KYNA) in RGC death against retinal ischemia/reperfusion (I/R ...
Houck, Julie A., Nam, Mi-Hyun, Johnson, Ginger C., Rankenberg, Johanna, Pantcheva, Mina B., MacLean, Paul S., Nagaraj, Ram H., Nahomi, Rooban B., Rakete, Stefan, Stankowska, Dorota L.   +9 more
core  

Lactobacillus regulate muscle fiber type conversion in Chinese native pigs via tryptophan metabolism

npj Biofilms and Microbiomes
Identifying potential gut microbes and metabolites that can influence muscle fiber type is gaining interest in meat quality research. In this study, muscle fiber characteristics, muscle metabolite profiles, and gut microbiota and metabolome were compared
Bo Song, Md. Abul Kalam Azad, Qian Zhu, Yating Cheng, Sujuan Ding, Kang Yao, Xiangfeng Kong   +6 more
doaj   +1 more source

Effect of kynurenic acid on LC neuronal activity following morphine withdrawal in morphine-dependent rats.

, 2015
Summary data showing the effect of kynurenic acid (500 μM) on the SDR (A: total and C: net) and RMP (B: total and D: net) of LC neurons following opiate withdrawal in all three slice forms taken from morphine treated rats.
Yaghoub Fathollahi (778334), Hossein Azizi (778332), Mohammad Javan (195590), S. Mohammad Ahmadi Soleimani (778333), Saeed Semnanian (778335), Ayat Kaeidi (778331)   +5 more
core   +1 more source

Losartan Reverses Hippocampal Increase of Kynurenic Acid in Type 1 Diabetic Rats: A Novel Procognitive Aspect of Sartan Action

Journal of Diabetes Research, 2019
Patients with diabetes mellitus (DM) type 1 and 2 are at a higher risk of cognitive decline and dementia; however, the underlying pathology is poorly understood.
Iwona Chmiel-Perzyńska, Adam Perzyński, Bartosz Olajossy, Paulina Gil-Kulik, Janusz Kocki, Ewa M. Urbańska   +5 more
doaj   +1 more source

CSF kynurenic acid and suicide risk in schizophrenia spectrum psychosis

, 2013
Relationships between concentrations of cerebrospinal fluid (CSF) kynurenic acid (KYNA) and suicidal behavior were evaluated in 59 patients with psychosis after 22 years of follow-up.
Jönsson, Erik G,, Nordström, Peter,, Jokinen, Jussi,, Andreas Carlborg, Sophie Erhardt, Carlborg, Andreas,, Erik G. Jönsson, Erhardt, Sophie,, Peter Nordström, Jussi Jokinen, Jonsson, EG, Nordstrom, P, Erhardt, S,, Carlborg, A,, Jokinen, J,   +14 more
core   +1 more source

Activation of nociception‐sensitive ionotropic glutamate receptor‐expressing rostroventrolateral medulla neurons by stimulation of cardiac afferents in rats

FASEB BioAdvances
Myocardial ischemia causes the release of bradykinin, which activates afferent nerve endings in the ventricular epicardium. This elicits a sympathetically mediated increase in arterial pressure and heart rate, referred to as the cardiogenic sympathetic ...
Matthew R. Zahner, Cade C. Oculam, Eric Beaumont   +2 more
doaj   +1 more source

Kynurenic acid blocks chemogenic nociception

, 1990
Previous studies have suggested a role of excitatory amino acids (EAA) in nociception. In the present study the effects of two antagonists of EAA-receptors on capsaicin-induced eye wipings were investigated.
Mihály Hajós, Göran Engberg
core   +1 more source

Association between usCRP and serum concentration of tryptophan, kynurenine, kynurenic acid, serotonin, K/T ratio and serotonin over tryptophan ratio.

, 2016
Association between usCRP and serum concentration of tryptophan, kynurenine, kynurenic acid, serotonin, K/T ratio and serotonin over tryptophan ratio.
Benjamin Hennart (205379), Loïc Yengo (160556), Gilles J. Guillemin (133306), Violeta Raverdy (3165681), Hélène Verkindt (3165666), Audrey Leloire (205385), Marie Pigeyre (3165678), Odile Poulain-Godefroy (154088), Marie Favennec (3165672), Delphine Allorge (205394), Marie Verbanck (3165675), Robert Caiazzo (3165669), François Pattou (145757), Philippe Froguel (2247)   +13 more
core   +1 more source