Results 61 to 70 of about 19,595 (226)
Clinical Pharmacology &Therapeutics, EarlyView.Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur +4 more
wiley +1 more source
Distress Intolerance, Kynurenic Acid, and Schizophrenia [PDF]
JAMA Psychiatry, 2014 We are all intuitively aware that when we are under stress, we think differently and often less well than when we are calmer. The study by Chiapelli et al1 in this issue of the journal addresses some of the critical links underlying the effects of stress on cognition.
openaire +2 more sources
Frontiers in Psychiatry, 2021 Hypofunction of glutamatergic signaling is causally linked to neurodevelopmental disorders, including psychotic disorders like schizophrenia and bipolar disorder.
Courtney J. Wright +5 more
doaj +1 more source
Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. [PDF]
, 2009 A principal objective of spinal cord injury (SCI) research is the restoration of axonal connectivity to denervated targets. We tested the hypothesis that chemotropic mechanisms would guide regenerating spinal cord axons to appropriate brainstem targets ...
Alto, Laura Taylor +5 more
core +2 more sources
Epilepsia Open, EarlyView.Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza +4 more
wiley +1 more source
Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes [PDF]
, 2005 Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA
Baran, H +5 more
core
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang +7 more
wiley +1 more source
Does the type of exercise affect tryptophan catabolism in horses?
Animal, 2021 Tryptophan (Trp) is an essential amino acid which metabolises via the kynurenine pathway to generate a number of bioactive substances referred to as kynurenines.
W. Kędzierski +4 more
doaj +1 more source
Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents : a cross-sectional analysis of two cohorts [PDF]
, 2018 Background: Tryptophan breakdown is an important mechanism in several diseases e.g. inflammation and stress induced inflammation have been associated with the development of depression via enhanced tryptophan breakdown.
Carvalho, Livia A +7 more
core +2 more sources