Results 61 to 70 of about 2,696,733 (168)

Perturbations of tryptophan catabolism via the kynurenine pathway are associated with stage 2 postoperative outcomes in single ventricle heart disease

Physiological Reports
Preliminary evidence suggests perturbations of the kynurenine pathway (KP) of tryptophan metabolism in infants with single ventricle heart disease (SVHD). In 72 infants with SVHD undergoing stage 2 palliation (S2P) and 41 controls, we quantified serum KP
Jennifer Romanowicz, Sierra Niemiec, Ludmila Khailova, Tanner Lehmann, Christopher A. Mancuso, Max B. Mitchell, Gareth J. Morgan, Mark Twite, Michael V. DiMaria, Jelena Klawitter, Jesse A. Davidson, Benjamin S. Frank   +11 more
doaj   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Similarity Between the Action of Pteridines and Tryptophan Metabolites on Lipid Metabolism

Pteridines, 1999
Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate, Krebs-Ringer-phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol. The addition of anthranilic acid (2.2 and
Rudzite Vera, Jurika Edite, Widner Bernhard, Fuchs Dietmar   +3 more
doaj   +1 more source

Developmental mechanisms contributing to non‐linear firing dynamics in spinal motoneurons of the postnatal mouse

The Journal of Physiology, EarlyView.
Abstract figure legend. In this study, we describe how persistent inward currents (PICs) and nonlinear firing dynamics mature in slow‐type (green) and fast‐type (purple) motoneurons (MNs) during the second and third postnatal weeks of development in mice.
Simon A. Sharples, Gareth B. Miles
wiley   +1 more source

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, Volume 183, Issue 21, Page 6481-6500, November 2026.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Protective effects of glucosamine-kynurenic acid after compression-induced spinal cord injury in the rat [PDF]

, 2012
Kynurenic acid (KYNA), a metabolite of the essential amino acid L-tryptophan, is a broad spectrum antagonist of excitatory amino acid receptors, which have also anticonvulsant and neuroprotective properties. After spinal cord injury (SCI), excitotoxicity
Toldi József, Korimova Andrea, Vécsei László, Cížková Dáša, Vanicky Ivo   +4 more
core   +1 more source

A Single Exercise Session Elicits a Transient Kynurenine Metabolic Signature in Health and Disease: A Systematic Review and Meta‐Analysis

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
A single exercise session transiently modulates systemic kynurenine pathway metabolism. Immediately after exercise, tryptophan decreases while kynurenine, KYN/TRP, kynurenic acid, and quinolinic acid increase. During recovery, lower tryptophan, higher KYN/TRP, and kynurenic acid remain.
Marcus Vinicius dos Santos Rangel, Gabriela Andrade Paz, Maria das Graças C. Souza, Marie Kupjetz, Tiffany Y. Wences Chirino, Philipp Zimmer, Paulo Farinatti, Juliana Pereira Borges   +7 more
wiley   +1 more source

BTBR mice have lower acetylcholine, and higher kynurenic acid levels in mPFC.

, 2013
Basal levels of acetylcholine (A; ACh) and kynurenic acid (B; KYNA) as measured by in vivo microdialysis in mPFC. In BTBR mice (n = 7) levels of acetylcholine were lower and kynurenic acid higher than C57 mice (n = 5) under baseline conditions.
Qian Lin (406644), Zoë A. Hughes (406645), Daniel G. Smith (406646), Stephanie M. McTighe (406642), Sarah J. Neal (406643)   +4 more
core   +1 more source

The Production of Kynurenic Acid from Tryptophane and Indole Derivatives [PDF]

, 1934
The production of kynurenic acid from derivatives closely related to tryptophane serves as a means of indicating whether the animal organism is able to accomplish the changes necessary to convert such derivatives into tryptophane itself, or into some ...
Bauguess, Lyle C., Berg, Clarence P.
core   +1 more source