Results 31 to 40 of about 1,141,006 (274)

The Role of Activation of the Tryptophan-Kynurenine Axis in the Pathogenesis of Acute Cerebrovascular Diseases: A Literature Review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Introduction: Acute cerebrovascular disorders are a major contributor to adult disability. The underlying processes that contribute to their development include inflammation, excitotoxicity, oxidative stress, and dysregulation of the tryptophan ...
Marina Grigolashvili, Alina Seryogina, Mira Beisembayeva, Shynar Muratbekova, Ivan Turkevich, Yelena Shayakhmetova   +5 more
doaj   +1 more source

The kynurenine pathway.

, 2020
The kynurenine pathway (KP) is the major route of Trp degradation. The first step is the formation of formylkynurenine from Trp, catalysed by hepatic tryptophan 2,3-dioxygenase (TDO), predominantly expressed in the liver, or indoleamine-2,3-dioxygenase ...
Per Magne Ueland (146309), Øivind Midttun (542701), Arve Ulvik (749228), Grete Slettom (7423286), Eva Kristine Ringdal Pedersen (8282676), Ottar Nygård (425679), Lasse Melvaer Giil (6823709), Anders Lund (744740), Jan Erik Nordrehaug (7448921), Stein-Erik Hafstad Solvang (8282673)   +9 more
core   +1 more source

Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain

Pharmaceuticals, 2023
Chronic pain is a pressing medical and socioeconomic issue worldwide. It is debilitating for individual patients and places a major burden on society in the forms of direct medical costs and lost work productivity.
Andrew Auyeung, Hank C. Wang, Kannan Aravagiri, Nebojsa Nick Knezevic   +3 more
doaj   +1 more source

The effect of electroconvulsive therapy (ECT) on serum kynurenine pathway metabolites in late-life depression

Journal of Affective Disorders Reports, 2023
Background: Depression is reportedly associated with alterations in kynurenine pathway metabolites (kynurenines). Several kynurenines are involved in glutamate signaling, and some have potentially neurotoxic effects while others are considered ...
Tore Ivar Malmei Aarsland, Jan Haavik, Arve Ulvik, Per Magne Ueland, Annemiek Dols, Ute Kessler   +5 more
doaj   +1 more source

The kynurenine pathway in major depressive disorder

, 2023
Major depressive disorder (MDD) is a serious psychiatric disorder, affecting over 264 million people globally. Despite its devastating and widespread burden, our current understanding of MDD neurobiology is limited.
Samara Brown (10722147)
core   +1 more source

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles, Schwarz, J.M., Berfelo, M. W., M. Schwarz, Vles, J. S. H., Schwarz, M., Hulsman, J. A. R. J., A. Myint, Majoie, H. J. M., M.W. Berfelo, Hulsman, J.A.R.J., K. Rijkers, Myint, A., J.A.R.J. Hulsman, Rijkers, K., H.J.M. Majoie   +15 more
core   +1 more source

Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway

Cell Communication and Signaling, 2023
Background Metabolic reprogramming is a critical event for cell fate and function, making it an attractive target for clinical therapy. The function of metabolic reprogramming in Helicobacter pylori (H.
Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong, Wanfu Xu   +10 more
doaj   +1 more source

Peripheral tryptophan and serotonin and kynurenine pathways in major depression: A case-control study

European Psychiatry, 2021
Introduction The tryptophan pathway along with its two branches of metabolism to serotonin and kynurenine seems to be affected in major depression.
R. Colle, C. Verstuyft, D. David, P. Chanson, E. Corruble   +4 more
doaj   +1 more source

Assessing and Modulating Kynurenine Pathway Dynamics in Huntington's Disease: Focus on Kynurenine 3-Monooxygenase.

, 2018
The link between disturbances in kynurenine pathway (KP) metabolism and Huntington's disease (HD) pathogenesis has been explored for a number of years.
Flaviano Giorgini (58325), Korrapati V. Sathyasaikumar (2276320), Carlo Breda (5076125), Robert Schwarcz (1870747)   +3 more
core   +7 more sources

Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma

Frontiers in Oncology, 2020
Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabolites
Soudabeh Rad Pour, Hiromasa Morikawa, Narsis A. Kiani, Narsis A. Kiani, David Gomez-Cabrero, David Gomez-Cabrero, Alistair Hayes, Xiaozhong Zheng, Maria Pernemalm, Janne Lehtiö, Damian J. Mole, Johan Hansson, Johan Hansson, Hanna Eriksson, Hanna Eriksson, Jesper Tegnér, Jesper Tegnér, Jesper Tegnér   +17 more
doaj   +1 more source