Results 31 to 40 of about 2,991,386 (293)

Interactions of IDO and the Kynurenine Pathway with Cell Transduction Systems and Metabolism at the Inflammation–Cancer Interface

Cancers, 2023
Simple Summary There is clear evidence that inflammation can contribute to the development of cancers, but the underlying mechanisms are not fully understood.
T. Stone, Richard O. Williams
semanticscholar   +1 more source

The Role of the Kynurenine Pathway in the Pathophysiology of Frailty, Sarcopenia, and Osteoporosis

Nutrients, 2023
Tryptophan is an essential nutrient required to generate vitamin B3 (niacin), which is mainly involved in energy metabolism and DNA production. Alterations in tryptophan metabolism could have significant effects on aging and musculoskeletal health.
J. Ballesteros, D. Rivas, Gustavo Duque
semanticscholar   +1 more source

Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes

Diabetes Care, 2023
OBJECTIVE We sought to study the associations between plasma metabolites in the tryptophan-kynurenine pathway and the risk of progression to end-stage kidney disease (ESKD) in patients with type 2 diabetes.
Jian-Jun Liu, J. Ching, H. Wee, Sylvia Liu, R. L. Gurung, Janus Lee, Y. M., Huili Zheng, Lye Siang Lee, K. Ang, Y. Shao, Jean-Paul Kovalik, T. Subramaniam, C. Sum, Kumar Sharma, B. Kestenbaum, S. Lim   +16 more
semanticscholar   +1 more source

Mapping an atlas of tissue-specific drosophila melanogaster metabolomes by high resolution mass spectrometry [PDF]

, 2013
Metabolomics can provide exciting insights into organismal function, but most work on simple models has focussed on the whole organism metabolome, so missing the contributions of individual tissues.
A Kamleh, A Malmendal, A Malmendal, AA Jackson, C Jeulin, David G. Watson, DG Watson, DJ Creek, Dominika Korzekwa, DT Sullivan, G Di Paolo, G Fraenkel, GJ Blomquist, GX Quan, H Colinet, J Andrews, J Overgaard, Jacob Guy Bundy, JD Feala, JE Treherne, JL Hubby, JS Park, Julian A. T. Dow, KS Pedersen, L Coquin, L Pan, L Zheng, M Carvalho, M Parisi, M Rera, MA Kamleh, MA Kamleh, MF Wolfner, MM Green, Mohammed Al Bratty, MS Elias, N Vereshchagina, NE Braverman, P Niewiadomska, PA Robitaille, PS Shekhawat, R Tearle, S Buch, S Reisse, V Kostal, Venkateswara R. Chintapalli, VR Chintapalli, VR Chintapalli   +47 more
core   +11 more sources

Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview

Mediators of Inflammation, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs.
Sagar Vyavahare, Sandeep Kumar, Nicholas Cantu, Ravindra Kolhe, Wendy B. Bollag, Meghan E. McGee-Lawrence, William D. Hill, Mark W. Hamrick, Carlos M. Isales, Sadanand Fulzele   +9 more
doaj   +1 more source

The kynurenine pathway presents multi-faceted metabolic vulnerabilities in cancer

Frontiers in Oncology, 2023
The kynurenine pathway (KP) and associated catabolites play key roles in promoting tumor progression and modulating the host anti-tumor immune response.
R. León-Letelier, Rongzhang Dou, J. Vykoukal, A. A. Sater, E. Ostrin, Samir Hanash, J. Fahrmann   +6 more
semanticscholar   +1 more source

Tryptophan metabolism as a ‘reflex’ feature of neuroimmune communication: Sensor and effector functions for the indoleamine‐2, 3‐dioxygenase kynurenine pathway

Journal of Neurochemistry, 2023
Although the central nervous system (CNS) and immune system were regarded as independent entities, it is now clear that immune system cells can influence the CNS, and neuroglial activity influences the immune system.
Trevor W Stone, Richard O. Williams
semanticscholar   +1 more source

Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review

Journal of Neuroinflammation, 2020
Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi, Osama Elyamany, Christoph Rummel, Christoph Mulert   +3 more
doaj   +1 more source

Kynurenine pathway abnormalities are state-specific but not diagnosis-specific in schizophrenia and bipolar disorder

Brain, behavior, & immunity - health, 2023
Schizophrenia (SCZ) and bipolar disorder (BD) are associated with immunological dysfunctions that have been hypothesized to lead to clinical symptomatology in particular through kynurenine pathway abnormalities.
K. Skorobogatov, V. Autier, M. Foiselle, J. Richard, W. Boukouaci, Ching-lien Wu, S. Raynal, C. Carbonne, K. Laukens, Pieter Meysman, V. Coppens, P. Le Corvoisier, C. Barau, L. De Picker, M. Morrens, R. Tamouza, M. Leboyer   +16 more
semanticscholar   +1 more source

Dietary Kynurenine Pathway Metabolites—Source, Fate, and Chromatographic Determinations

International Journal of Molecular Sciences, 2023
Tryptophan metabolism plays an essential role in human health. In mammals, about 95% of dietary tryptophan is metabolized through the kynurenine pathway, which is associated with the development of several pathologies, including neurodegeneration.
I. Sadok, Katarzyna Jędruchniewicz
semanticscholar   +1 more source