Results 31 to 40 of about 1,450,510 (208)
Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain
Pharmaceuticals, 2023 Chronic pain is a pressing medical and socioeconomic issue worldwide. It is debilitating for individual patients and places a major burden on society in the forms of direct medical costs and lost work productivity.
Andrew Auyeung +3 more
doaj +1 more source
Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile [PDF]
, 2014 Tryptophan is an important precursor for chemical entities that ultimately support the biosynthesis of key metabolites. The second stage of tryptophan catabolism is catalysed by kynurenine formamidase, an enzyme that is different between eukaryotes and ...
Zoltner, Martin +3 more
core +1 more source
Antioxidants, 2022 Acute respiratory distress syndrome (ARDS) involves dysregulated immune-inflammatory responses, characterized by severe oxidative stress and high mortality.
Li-Chung Chiu +6 more
doaj +1 more source
Kynurenines in CNS disease: regulation by inflammatory cytokines
Frontiers in Neuroscience, 2014 The kynurenine pathway metabolizes the essential amino acid tryptophan and generates a number of neuroactive metabolites collectively called the kynurenines.
Brian M Campbell +3 more
doaj +1 more source
Kynurenine pathway activation in Human African trypanosomiasis [PDF]
, 2017 Background: The kynurenine pathway of tryptophan oxidation is associated with CNS inflammatory pathways. Inhibition of this pathway ameliorates CNS inflammation in rodent models of the late (meningoencephalitic) stage of Human African trypanosomiasis ...
Turner, Charles +7 more
core +1 more source
Altered Kynurenine Pathway Metabolism in Rats Fed Added Sugars
Genel Tıp Dergisi, 2022 Aim: The consumption of added sugars containing fructose has increased dramatically. Various studies have revealed that added sugar consumption may be involved in the pathogenesis of cardiovascular, metabolic and neurocognitive disorders by triggering ...
Bahadir Ozturk, Duygu Eryavuz Onmaz
doaj +1 more source
, 2020 The kynurenine pathway (KP) is the major route of Trp degradation. The first step is the formation of formylkynurenine from Trp, catalysed by hepatic tryptophan 2,3-dioxygenase (TDO), predominantly expressed in the liver, or indoleamine-2,3-dioxygenase ...
Per Magne Ueland (146309) +9 more
core +1 more source
Cell Communication and Signaling, 2023 Background Metabolic reprogramming is a critical event for cell fate and function, making it an attractive target for clinical therapy. The function of metabolic reprogramming in Helicobacter pylori (H.
Xinhua Liang +10 more
doaj +1 more source
Journal of Affective Disorders Reports, 2023 Background: Depression is reportedly associated with alterations in kynurenine pathway metabolites (kynurenines). Several kynurenines are involved in glutamate signaling, and some have potentially neurotoxic effects while others are considered ...
Tore Ivar Malmei Aarsland +5 more
doaj +1 more source
Role of kynurenine pathway in allergy
, 2016 [[abstract]]Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation.
Kawasaki, H;Huang, SK
core +1 more source