Results 21 to 30 of about 2,991,386 (293)
The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]
Medicinski Podmladak, 2023 The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš +2 more
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Kynurenine pathway in kidney diseases [PDF]
Pharmacological Reports, 2021 AbstractKidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders the prevalence of these diseases will increase over the coming decades. Despite available laboratory tests, accurate and rapid diagnosis of renal dysfunction has yet to be realized, and prognosis ...
Izabela Zakrocka, Wojciech Załuska
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The kynurenine pathway in Alzheimer’s disease: a meta-analysis of central and peripheral levels [PDF]
Brazilian Journal of Psychiatry, 2023 Objective: Changes in the kynurenine pathway are recognized in psychiatric disorders, but their role in Alzheimer’s disease (AD) is less clear. We aimed to conduct a systematic review and meta-analysis to determine whether tryptophan and kynurenine ...
Brisa S. Fernandes +4 more
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Linking major depressive disorder pathogenesis with kynurenine pathway - a literature review
Journal of Education, Health and Sport, 2023 Introduction: Depressive disorders are a significant problem. They lead to suffering, loss of interest and may contribute to suicide attempts. Despite the large number of available medications, 10-35% of patients fail to achieve remission.
Dominik Szawica +4 more
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Critical Care Medicine, 2012 The kynurenine pathway represents a major route for the catabolism of tryptophan (TRP). In the body, TRP is transported around the periphery either bound to albumin (90%) or in free form (10%), the two states existing in equilibrium (McMenamy 1965). However, only free form TRP can be transported across the blood-brain barrier (BBB) by the competitive ...
Yiquan Chen, Gilles Guillemi
openaire +5 more sources
Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease. [PDF]
PLoS ONE, 2015 The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the pathogenesis of a wide variety of inflammatory, neurodegenerative and malignant disorders ...
Simon P Jones +8 more
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Modulation of T cells by tryptophan metabolites in the kynurenine pathway.
TIPS - Trends in Pharmacological Sciences, 2023 Lymphocytes maturing in the thymus (T cells) are key factors in adaptive immunity and the regulation of inflammation. The kynurenine pathway of tryptophan metabolism includes several enzymes and compounds that can modulate T cell function, but ...
T. Stone, Richard O. Williams
semanticscholar +1 more source
The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases
International Journal of Molecular Sciences, 2023 The tryptophan and kynurenine pathway is well-known to play an important role in nervous, endocrine, and immune systems, as well as in the development of inflammatory diseases.
Ai Tsuji +8 more
semanticscholar +1 more source
Kynurenine Pathway in Diabetes Mellitus—Novel Pharmacological Target?
Cells, 2023 The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion in the brain and in the periphery. Kynurenines display a wide range of biological actions (which are often contrasting) such as cytotoxic/cytoprotective, oxidant ...
K. Kozieł, E. Urbańska
semanticscholar +1 more source
Kynurenines and Neurofilament Light Chain in Multiple Sclerosis
Frontiers in Neuroscience, 2021 Multiple sclerosis is an autoimmune, demyelinating, and neurodegenerative disease of the central nervous system. In recent years, it has been proven that the kynurenine system plays a significant role in the development of several nervous system ...
Dániel Pukoli +5 more
doaj +1 more source