The role of the kynurenine pathway in the pathogenesis of pain and affective disorders after traumatic brain injury. [PDF]
Brain Behav Immun HealthTraumatic brain injury (TBI) alters neuroimmune physiology resulting in an imbalance between pro- and anti-inflammatory cascades. Whereas acute inflammation serves as an adaptive defense mechanism of the innate immune system to promote healing and ...
Nahmoud I +3 more
europepmc +2 more sources
The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]
Medicinski Podmladak, 2023 The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš +2 more
doaj +1 more source
Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease. [PDF]
PLoS ONE, 2015 The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the pathogenesis of a wide variety of inflammatory, neurodegenerative and malignant disorders ...
Simon P Jones +8 more
doaj +1 more source
Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease
Frontiers in Immunology, 2022 Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc.
Renáta Gáspár +10 more
doaj +1 more source
Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review
Journal of Neuroinflammation, 2020 Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi +3 more
doaj +1 more source
Kynurenine Pathway in Psoriasis—a Promising Link?
Dermatology and Therapy, 2023 Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome.
A. Stepaniuk, A. Baran, I. Flisiak
doaj +1 more source
"Kynurenine Pathway and Diseases Associated With Its Dysfunction "
, 2022 : The kynurenine pathway is a metabolic mechanism that results in the synthesis of nicotinamide adenine dinucleotide. Tryptophan, kynurenine, kynurenic acid, xanthurenic acid, quinolinic acid, and 3-hydroxykynurenine are among the metabolites involved ...
Fathima Buthul, Dr. Syeda Nishat Fathima
core +1 more source
Kynurenines and Neurofilament Light Chain in Multiple Sclerosis
Frontiers in Neuroscience, 2021 Multiple sclerosis is an autoimmune, demyelinating, and neurodegenerative disease of the central nervous system. In recent years, it has been proven that the kynurenine system plays a significant role in the development of several nervous system ...
Dániel Pukoli +5 more
doaj +1 more source
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]
, 2009 Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Barrett, M.P. +4 more
core +1 more source
Journal of Neuroinflammation, 2021 Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS
Vincent Millischer +9 more
doaj +1 more source