Results 21 to 30 of about 23,868 (155)

Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial

Journal of Neuroinflammation, 2021
Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS
Vincent Millischer, Matthias Heinzl, Anthi Faka, Michael Resl, Ada Trepci, Carmen Klammer, Margot Egger, Benjamin Dieplinger, Martin Clodi, Lilly Schwieler   +9 more
doaj   +1 more source

Kynurenine Pathway of Tryptophan Metabolism Is Associated with Hospital Mortality in Patients with Acute Respiratory Distress Syndrome: A Prospective Cohort Study

Antioxidants, 2022
Acute respiratory distress syndrome (ARDS) involves dysregulated immune-inflammatory responses, characterized by severe oxidative stress and high mortality.
Li-Chung Chiu, Hsiang-Yu Tang, Chun-Ming Fan, Chi-Jen Lo, Han-Chung Hu, Kuo-Chin Kao, Mei-Ling Cheng   +6 more
doaj   +1 more source

Kynurenine pathway in bipolar disorder [PDF]

Psychiatriki, 2019
Bipolar disorder (BD) is a chronic psychiatric illness which, among other things, is characterized by cerebral dysfunctions, cognitive disorders and sleep disturbances. The neurobiological basis of these processes remains unclear. In recent years, studies have focused on the role of immune-inflammatory mechanisms induced by the tryptophan metabolism ...
Konstantinou, G., Papageorgiou, C.C., Angelopoulos, E.   +2 more
openaire   +3 more sources

Involvement of Kynurenine Pathway in Hepatocellular Carcinoma [PDF]

Cancers, 2021
As the second and third leading cancer-related death in men and the world, respectively, primary liver cancer remains a major concern to human health. Despite advances in diagnostic technology, patients with primary liver cancer are often diagnosed at an advanced stage.
Shivani Krishnamurthy, David Gilot, Seong Beom Ahn, Vincent Lam, Joo-Shik Shin, Gilles Jackie Guillemin, Benjamin Heng   +6 more
openaire   +3 more sources

The Role of Activation of the Tryptophan-Kynurenine Axis in the Pathogenesis of Acute Cerebrovascular Diseases: A Literature Review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Introduction: Acute cerebrovascular disorders are a major contributor to adult disability. The underlying processes that contribute to their development include inflammation, excitotoxicity, oxidative stress, and dysregulation of the tryptophan ...
Marina Grigolashvili, Alina Seryogina, Mira Beisembayeva, Shynar Muratbekova, Ivan Turkevich, Yelena Shayakhmetova   +5 more
doaj   +1 more source

Altered Kynurenine Pathway Metabolism in Rats Fed Added Sugars

Genel Tıp Dergisi, 2022
Aim: The consumption of added sugars containing fructose has increased dramatically. Various studies have revealed that added sugar consumption may be involved in the pathogenesis of cardiovascular, metabolic and neurocognitive disorders by triggering ...
Bahadir Ozturk, Duygu Eryavuz Onmaz
doaj   +1 more source

Kynurenine pathway metabolites in migraine [PDF]

The Journal of Headache and Pain, 2015
Kynurenine pathway (KP), the quantitatively main branch of tryptophan metabolism, has long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to activate glutamate receptors, thus potentially influencing a large group of functions in the central ...
openaire   +2 more sources

Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain

Pharmaceuticals, 2023
Chronic pain is a pressing medical and socioeconomic issue worldwide. It is debilitating for individual patients and places a major burden on society in the forms of direct medical costs and lost work productivity.
Andrew Auyeung, Hank C. Wang, Kannan Aravagiri, Nebojsa Nick Knezevic   +3 more
doaj   +1 more source

The effect of electroconvulsive therapy (ECT) on serum kynurenine pathway metabolites in late-life depression

Journal of Affective Disorders Reports, 2023
Background: Depression is reportedly associated with alterations in kynurenine pathway metabolites (kynurenines). Several kynurenines are involved in glutamate signaling, and some have potentially neurotoxic effects while others are considered ...
Tore Ivar Malmei Aarsland, Jan Haavik, Arve Ulvik, Per Magne Ueland, Annemiek Dols, Ute Kessler   +5 more
doaj   +1 more source

Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway

Cell Communication and Signaling, 2023
Background Metabolic reprogramming is a critical event for cell fate and function, making it an attractive target for clinical therapy. The function of metabolic reprogramming in Helicobacter pylori (H.
Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong, Wanfu Xu   +10 more
doaj   +1 more source