Results 21 to 30 of about 26,876 (282)
Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease. [PDF]
PLoS ONE, 2015 The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the pathogenesis of a wide variety of inflammatory, neurodegenerative and malignant disorders ...
Simon P Jones +8 more
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Kynurenines and Neurofilament Light Chain in Multiple Sclerosis
Frontiers in Neuroscience, 2021 Multiple sclerosis is an autoimmune, demyelinating, and neurodegenerative disease of the central nervous system. In recent years, it has been proven that the kynurenine system plays a significant role in the development of several nervous system ...
Dániel Pukoli +5 more
doaj +1 more source
The kynurenine pathway in cognition, dementia, and aging [PDF]
, 2021 Background: Experimental studies implicate the kynurenine pathway in cognitive function, dementia, aging, and longevity. Comparatively, clinical studies are few and most lack comprehensive targeted metabolomic profiling of the kynurenine pathway ...
Solvang, Stein-Erik Hafstad
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Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review
Journal of Neuroinflammation, 2020 Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi +3 more
doaj +1 more source
The kynurenine pathway and neurodegenerative disease [PDF]
Seminars in Cell & Developmental Biology, 2015 Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan is an essential amino acid required for protein synthesis, and in higher eukaryotes is also converted into the key neurotransmitters serotonin and tryptamine. However, in mammals
Maddison, Daniel C., Giorgini, Flaviano
openaire +3 more sources
Critical Care Medicine, 2012 The kynurenine pathway represents a major route for the catabolism of tryptophan (TRP). In the body, TRP is transported around the periphery either bound to albumin (90%) or in free form (10%), the two states existing in equilibrium (McMenamy 1965). However, only free form TRP can be transported across the blood-brain barrier (BBB) by the competitive ...
Yiquan Chen, Gilles Guillemi
openaire +4 more sources
Addiction and the kynurenine pathway: A new dancing couple?
, 2021 Drug use poses a serious threat to health systems throughout the world and the number of consumers rises relentlessly every year. The kynurenine pathway, main pathway of tryptophan degradation, has drawn interest in this field due to its relationship ...
Morales Puerto, Nuria +8 more
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Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]
, 2009 Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Barrett, M.P. +4 more
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Kynurenines in CNS disease: regulation by inflammatory cytokines
Frontiers in Neuroscience, 2014 The kynurenine pathway metabolizes the essential amino acid tryptophan and generates a number of neuroactive metabolites collectively called the kynurenines.
Brian M Campbell +3 more
doaj +1 more source
Antioxidants, 2022 Acute respiratory distress syndrome (ARDS) involves dysregulated immune-inflammatory responses, characterized by severe oxidative stress and high mortality.
Li-Chung Chiu +6 more
doaj +1 more source