Results 21 to 30 of about 1,141,006 (274)
Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile [PDF]
, 2014 Tryptophan is an important precursor for chemical entities that ultimately support the biosynthesis of key metabolites. The second stage of tryptophan catabolism is catalysed by kynurenine formamidase, an enzyme that is different between eukaryotes and ...
Zoltner, Martin +3 more
core +1 more source
The kynurenine pathway and neurodegenerative disease [PDF]
Seminars in Cell & Developmental Biology, 2015 Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan is an essential amino acid required for protein synthesis, and in higher eukaryotes is also converted into the key neurotransmitters serotonin and tryptamine. However, in mammals
Maddison, Daniel C., Giorgini, Flaviano
openaire +3 more sources
Kynurenines in CNS disease: regulation by inflammatory cytokines
Frontiers in Neuroscience, 2014 The kynurenine pathway metabolizes the essential amino acid tryptophan and generates a number of neuroactive metabolites collectively called the kynurenines.
Brian M Campbell +3 more
doaj +1 more source
Journal of Neuroinflammation, 2021 Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS
Vincent Millischer +9 more
doaj +1 more source
Kynurenine pathway in bipolar disorder [PDF]
Psychiatriki, 2019 Bipolar disorder (BD) is a chronic psychiatric illness which, among other things, is characterized by cerebral dysfunctions, cognitive disorders and sleep disturbances. The neurobiological basis of these processes remains unclear. In recent years, studies have focused on the role of immune-inflammatory mechanisms induced by the tryptophan metabolism ...
Konstantinou, G. +2 more
openaire +3 more sources
Involvement of Kynurenine Pathway in Hepatocellular Carcinoma [PDF]
Cancers, 2021 As the second and third leading cancer-related death in men and the world, respectively, primary liver cancer remains a major concern to human health. Despite advances in diagnostic technology, patients with primary liver cancer are often diagnosed at an advanced stage.
Shivani Krishnamurthy +6 more
openaire +3 more sources
Antioxidants, 2022 Acute respiratory distress syndrome (ARDS) involves dysregulated immune-inflammatory responses, characterized by severe oxidative stress and high mortality.
Li-Chung Chiu +6 more
doaj +1 more source
"Kynurenine Pathway and Diseases Associated With Its Dysfunction "
, 2022 : The kynurenine pathway is a metabolic mechanism that results in the synthesis of nicotinamide adenine dinucleotide. Tryptophan, kynurenine, kynurenic acid, xanthurenic acid, quinolinic acid, and 3-hydroxykynurenine are among the metabolites involved ...
Fathima Buthul, Dr. Syeda Nishat Fathima
core +1 more source
Kynurenine pathway activation in Human African trypanosomiasis [PDF]
, 2017 Background: The kynurenine pathway of tryptophan oxidation is associated with CNS inflammatory pathways. Inhibition of this pathway ameliorates CNS inflammation in rodent models of the late (meningoencephalitic) stage of Human African trypanosomiasis ...
Turner, Charles +7 more
core +1 more source
Altered Kynurenine Pathway Metabolism in Rats Fed Added Sugars
Genel Tıp Dergisi, 2022 Aim: The consumption of added sugars containing fructose has increased dramatically. Various studies have revealed that added sugar consumption may be involved in the pathogenesis of cardiovascular, metabolic and neurocognitive disorders by triggering ...
Bahadir Ozturk, Duygu Eryavuz Onmaz
doaj +1 more source